Author name: Kelly Newman

gotta-go?-we’ve-finally-found-out-what-makes-urine-yellow

Gotta go? We’ve finally found out what makes urine yellow

It isn’t from eating corn —

The yellow color comes from bacteria metabolizing waste from red blood cells.

Image of a series of scientific sample tubes filled with yellow liquids.

There are many mysteries in life that we end up shrugging off. Why is urine yellow? It just is, right? Rather than flush that 125-year-old question down the toilet, scientists sought out the answer, discovering a previously unknown microbial enzyme was to blame.

The enzyme that has eluded us for so long is now known as bilirubin reductase. It was identified by researcher and assistant professor Brantley Hall of the University of Maryland, who was part of a team based at the university and the National Institutes of Health.

Bilirubin is an orange pigment released by red blood cells after they die. Gut microbes then use bilirubin reductase to break down bilirubin into colorless urobilinogen, which degrades into yellowish urobilin, giving urine that infamous hue. While urobilin previously had an association with the color of urine, the enzyme that starts the process by producing urobilinogen was unknown until now.

“Though it was previously thought that multiple enzymes were involved in the reduction of bilirubin, our results support the finding that a single enzyme performs the reduction of bilirubin to urobilinogen,” the research team said in a study recently published in Nature Microbiology.

Gut feeling

Because some gut bacteria had been known to reduce bilirubin, Hall and his team knew where to start but wanted to fill in the unknowns by finding out which particular species actually do this—and how. This meant they had to find the gene responsible for encoding bilirubin reductase.

Previous studies had found that the species Clostridiodes difficile was capable of reducing bilirubin (though the mechanism it used was unknown). Using C. difficile as a basis for comparison, the team cultured different species of gut bacteria and exposed them to bilirubin to see whether that bacteria could produce urobilinogen, detecting its presence using a fluorescence assay.

The fluorescence assay told Hall and his colleagues that there were nine strains within the tested species that they thought were capable of reducing bilirubin, although how these bacteria were breaking it down was still unclear.  After the fluorescence assay, the genomes of the most closely related strains were analyzed,  and several turned out to share a gene that encoded an enzyme that could reduce bilirubin—bilirubin reductase.

Bacterial strains that metabolized bilirubin using bilirubin reductase all came from species that were found to belong to a single clade (the researchers informally referred to it as the bilirubin reductase clade). Within that clade, most of these species are from the class Clostridia in the phylum Firmicutes, a phylum of bacteria important to gut health.

More than … you know

The discovery of bilirubin reductase goes beyond the origin of urine color. After identifying the enzyme, the researchers found out that, while bilirubin reductase is present in healthy adults, there is a deficit in newborns and adults with inflammatory bowel disease, which could eventually influence future treatments

By sequencing infant gut genomes, Hall and his team saw that bilirubin reductase was often missing during the first few months of life. Too much bilirubin building up in the blood turns the skin and the whites of the eyes yellow, a symptom known as jaundice. Most infants have some level of jaundice, but it usually goes away on its own.

The absence of bilirubin reductase is also associated with pigmented gallstones in adults with inflammatory bowel disease (inflammatory bowel disease or IBD is a general term that can refer to several different diagnoses). Sequencing adult gut genomes showed that there was a deficit of this enzyme in most patients with Crohn’s disease or ulcerative colitis whose gut genomes were sequenced.

“With the knowledge of the species, genes, and enzymes involved in bilirubin reduction, future research can now focus on the extent to which gut microbial bilirubin metabolism affects…the role of bilirubin reduction in health and disease,” the researchers said in the same study.

There is still more research to be done on bilirubin reductase and the health implications it could have. The team thinks there may be a link between the amount of urobilin produced in the body and insulin resistance, obesity, heart disease, and even heart failure. Next to that, we finally know why urine is yellow.

Nature Microbiology, 2023. DOI: 10.1038/s41564-023-01549-x

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air-pollution-from-canada’s-tar-sands-is-much-worse-than-we-thought

Air pollution from Canada’s tar sands is much worse than we thought

Aerial Views Of Oil Sands Operations

Enlarge / Aerial view of the Athabasca oil sands near Fort McMurray, Alberta, Canada.

Canada’s tar sands have gained infamy for being one of the world’s most polluting sources of oil, thanks to the large amounts of energy and water use required for their extraction. A new study says the operations are also emitting far higher levels of a range of air pollutants than previously known, with implications for communities living nearby and far downwind.

The research, published Thursday in Science, took direct measurements of organic carbon emissions from aircraft flying above the tar sands, also called oil sands, and found levels that were 20 to 64 times higher than what companies were reporting. Total organic carbon includes a wide range of compounds, some of which can contribute directly to hazardous air pollution locally and others that can react in the atmosphere to form small particulate matter, or PM 2.5, a dangerous pollutant that can travel long distances and lodge deep in the lungs.

The study found that tar sands operations were releasing as much of these pollutants as all other human-made sources in Canada combined. For certain classes of heavy organic compounds, which are more likely to form particulates downwind, the concentrations were higher than what’s generally found in large metropolises like Los Angeles.

“The absolute magnitude of those emissions were a lot higher than what we expected,” said John Liggio, a research scientist at Environment and Climate Change Canada, the nation’s environmental regulatory agency, and a co-author on the study. Researchers at Yale University also contributed.

Seth Shonkoff, executive director of PSE Healthy Energy, an independent scientific research institute in California, who was not involved in the study, said the findings suggest air pollution from tar sands operations is more damaging to people’s health than previously known.

“I actually could hardly believe what I was reading,” Shonkoff said of the new study.

Over the last decade, a growing body of research has examined emissions of different air pollutants from oil and gas operations across the United States and Canada, and much of that has shown that industry estimates tend to undercount what’s being released, he said. “But the scale of this discrepancy is very surprising.”

Mark Cameron, vice president of external relations at the Pathways Alliance, an oil sands industry group, said in an email that the findings warrant further review and that “the oil sands industry measures emissions using standards set by Environment and Climate Change Canada and we look forward to working together to explore opportunities to further enhance our measurement practices.”

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i-abandoned-openlitespeed-and-went-back-to-good-ol’-nginx

I abandoned OpenLiteSpeed and went back to good ol’ Nginx

Adventures in server babysitting —

One weather site’s sudden struggles, and musings on why change isn’t always good.

Ish is on fire, yo.

Enlarge / Ish is on fire, yo.

Since 2017, in what spare time I have (ha!), I help my colleague Eric Berger host his Houston-area weather forecasting site, Space City Weather. It’s an interesting hosting challenge—on a typical day, SCW does maybe 20,000–30,000 page views to 10,000–15,000 unique visitors, which is a relatively easy load to handle with minimal work. But when severe weather events happen—especially in the summer, when hurricanes lurk in the Gulf of Mexico—the site’s traffic can spike to more than a million page views in 12 hours. That level of traffic requires a bit more prep to handle.

Space City Weather!” data-height=”2008″ data-width=”2560″ href=”https://cdn.arstechnica.net/wp-content/uploads/2024/01/Screenshot-2024-01-24-at-9.02.05%E2%80%AFAM.jpg”>Hey, it's <a href=Space City Weather!” height=”235″ src=”https://cdn.arstechnica.net/wp-content/uploads/2024/01/Screenshot-2024-01-24-at-9.02.05%E2%80%AFAM.jpg” width=”300″>

Lee Hutchinson

For a very long time, I ran SCW on a backend stack made up of HAProxy for SSL termination, Varnish Cache for on-box caching, and Nginx for the actual web server application—all fronted by Cloudflare to absorb the majority of the load. (I wrote about this setup at length on Ars a few years ago for folks who want some more in-depth details.) This stack was fully battle-tested and ready to devour whatever traffic we threw at it, but it was also annoyingly complex, with multiple cache layers to contend with, and that complexity made troubleshooting issues more difficult than I would have liked.

So during some winter downtime two years ago, I took the opportunity to jettison some complexity and reduce the hosting stack down to a single monolithic web server application: OpenLiteSpeed.

Out with the old, in with the new

I didn’t know too much about OpenLiteSpeed (“OLS” to its friends) other than that it’s mentioned a bunch in discussions about WordPress hosting—and since SCW runs WordPress, I started to get interested. OLS seemed to get a lot of praise for its integrated caching, especially when WordPress was involved; it was purported to be quite quick compared to Nginx; and, frankly, after five-ish years of admining the same stack, I was interested in changing things up. OpenLiteSpeed it was!

check my blog. Yeah, I still have a blog. I’m old.” data-height=”1442″ data-width=”2318″ href=”https://cdn.arstechnica.net/wp-content/uploads/2024/01/Screen-Shot-2022-06-09-at-6.37.47-AM-1.jpg”>The OLS admin console, showing vhosts. This is from my personal web server rather than the Space City Weather server, but it looks the same. If you want some deeper details on the OLS config I was using, <a href=check my blog. Yeah, I still have a blog. I’m old.” height=”398″ src=”https://cdn.arstechnica.net/wp-content/uploads/2024/01/Screen-Shot-2022-06-09-at-6.37.47-AM-1.jpg” width=”640″>

Enlarge / The OLS admin console, showing vhosts. This is from my personal web server rather than the Space City Weather server, but it looks the same. If you want some deeper details on the OLS config I was using, check my blog. Yeah, I still have a blog. I’m old.

Lee Hutchinson

The first significant adjustment to deal with was that OLS is primarily configured through an actual GUI, with all the annoying potential issues that brings with it (another port to secure, another password to manage, another public point of entry into the backend, more PHP resources dedicated just to the admin interface). But the GUI was fast, and it mostly exposed the settings that needed exposing. Translating the existing Nginx WordPress configuration into OLS-speak was a good acclimation exercise, and I eventually settled on Cloudflare tunnels as an acceptable method for keeping the admin console hidden away and notionally secure.

Just a taste of the options that await within the LiteSpeed Cache WordPress plugin.

Enlarge / Just a taste of the options that await within the LiteSpeed Cache WordPress plugin.

Lee Hutchinson

The other major adjustment was the OLS LiteSpeed Cache plugin for WordPress, which is the primary tool one uses to configure how WordPress itself interacts with OLS and its built-in cache. It’s a massive plugin with pages and pages of configurable options, many of which are concerned with driving utilization of the Quic.Cloud CDN service (which is operated by LiteSpeed Technology, the company that created OpenLiteSpeed and its for-pay sibling, LiteSpeed).

Getting the most out of WordPress on OLS meant spending some time in the plugin, figuring out which of the options would help and which would hurt. (Perhaps unsurprisingly, there are plenty of ways in there to get oneself into stupid amounts of trouble by being too aggressive with caching.) Fortunately, Space City Weather provides a great testing ground for web servers, being a nicely active site with a very cache-friendly workload, and so I hammered out a starting configuration with which I was reasonably happy and, while speaking the ancient holy words of ritual, flipped the cutover switch. HAProxy, Varnish, and Nginx went silent, and OLS took up the load.

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cruise-failed-to-disclose-disturbing-details-of-self-driving-car-crash

Cruise failed to disclose disturbing details of self-driving car crash

full disclosure —

Company did not share all it knew about the accident with regulators.

A Cruise robotaxi test vehicle in San Francisco.

Enlarge / A Cruise robotaxi test vehicle in San Francisco.

Cruise

A law firm hired by the General Motors’ self-driving subsidiary Cruise to investigate the company’s response to a gruesome San Francisco crash last year found that the company failed to fully disclose disturbing details to regulators, the tech company said today in a blog post. The incident in October led California regulators to suspend Cruise’s license to operate driverless vehicles in San Francisco.

The new report by law firm Quinn Emanuel says that Cruise failed to tell California’s Department of Motor Vehicles that after striking a pedestrian knocked into its path by a human-driven vehicle, the autonomous car pulled out of traffic—dragging her some 20 feet. Cruise said it had accepted the firm’s version of events, as well as its recommendations.

The investigators found that when Cruise played a video of the crash taken from its autonomous vehicle for government officials, it did not “verbally point out” the vehicle’s pullover maneuver. Internet connectivity issues that occurred when the company tried to share video of the incident “likely precluded or hampered” regulators from seeing the full video, the report concluded.

Cruise executives are singled out in the report for failing to properly communicate with regulators. Company leaders assumed that regulators would ask questions that would lead the company to provide more information about the pedestrian dragging, the report says. And Cruise leadership is described as “fixated” on demonstrating to the media that it was a human-driven car, not its autonomous vehicle, that first struck the pedestrian. That “myopic focus,” the law firm concludes, led Cruise to “omit other important information” about the incident.

“The reasons for Cruise’s failings in this instance are numerous,” the law firm concluded, “poor leadership, mistakes in judgment, lack of coordination, an ‘us versus them’ mentality with regulators, and a fundamental misapprehension of Cruise’s obligations of accountability and transparency to the government and the public.” It said the company must take “decisive steps” to restore public trust.

Another third-party report on the crash released by Cruise today, by the engineering consulting firm Exponent, found that technical issues contributed to the autonomous vehicle’s dangerous pullover maneuver. Although the self-driving car’s software correctly detected, perceived, and tracked the pedestrian and the human-driven car, it classified the crash as a side-impact collision, which led it to pull over and drag the woman underneath it. Cruise says its technical issues were corrected when it recalled its software in November.

Cruise has paused its self-driving operations across the US since late October. Nine executives, plus CEO and cofounder Kyle Vogt, left in the fallout from the crash. In late 2023, the company laid off almost a quarter of its employees. General Motors says it will cut spending on the tech company by hundreds of millions of dollars this year compared to last.

This story originally appeared on wired.com.

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the-life-and-times-of-cozy-bear,-the-russian-hackers-who-just-hit-microsoft-and-hpe

The life and times of Cozy Bear, the Russian hackers who just hit Microsoft and HPE

FROM RUSSIA WITH ROOT —

Hacks by Kremlin-backed group continue to hit hard.

The life and times of Cozy Bear, the Russian hackers who just hit Microsoft and HPE

Getty Images

Hewlett Packard Enterprise (HPE) said Wednesday that Kremlin-backed actors hacked into the email accounts of its security personnel and other employees last May—and maintained surreptitious access until December. The disclosure was the second revelation of a major corporate network breach by the hacking group in five days.

The hacking group that hit HPE is the same one that Microsoft said Friday broke into its corporate network in November and monitored email accounts of senior executives and security team members until being driven out earlier this month. Microsoft tracks the group as Midnight Blizzard. (Under the company’s recently retired threat actor naming convention, which was based on chemical elements, the group was known as Nobelium.) But it is perhaps better known by the name Cozy Bear—though researchers have also dubbed it APT29, the Dukes, Cloaked Ursa, and Dark Halo.

“On December 12, 2023, Hewlett Packard Enterprise was notified that a suspected nation-state actor, believed to be the threat actor Midnight Blizzard, the state-sponsored actor also known as Cozy Bear, had gained unauthorized access to HPE’s cloud-based email environment,” company lawyers wrote in a filing with the Securities and Exchange Commission. “The Company, with assistance from external cybersecurity experts, immediately activated our response process to investigate, contain, and remediate the incident, eradicating the activity. Based on our investigation, we now believe that the threat actor accessed and exfiltrated data beginning in May 2023 from a small percentage of HPE mailboxes belonging to individuals in our cybersecurity, go-to-market, business segments, and other functions.”

An HPE representative said in an email that Cozy Bear’s initial entry into the network was through “a compromised, internal HPE Office 365 email account [that] was leveraged to gain access.” The representative declined to elaborate. The representative also declined to say how HPE discovered the breach.

Cozy Bear hacking its way into the email systems of two of the world’s most powerful companies and monitoring top employees’ accounts for months aren’t the only similarities between the two events. Both breaches also involved compromising a single device on each corporate network, then escalating that toehold to the network itself. From there, Cozy Bear camped out undetected for months. The HPE intrusion was all the more impressive because Wednesday’s disclosure said that the hackers also gained access to Sharepoint servers in May. Even after HPE detected and contained that breach a month later, it would take HPE another six months to discover the compromised email accounts.

The pair of disclosures, coming within five days of each other, may create the impression that there has been a recent flurry of hacking activity. But Cozy Bear has actually been one of the most active nation-state groups since at least 2010. In the intervening 14 years, it has waged an almost constant series of attacks, mostly on the networks of governmental organizations and the technology companies that supply them. Multiple intelligence services and private research companies have attributed the hacking group as an arm of Russia’s Foreign Intelligence Service, also known as the SVR.

The life and times of Cozy Bear (so far)

In its earliest years, Cozy Bear operated in relative obscurity—precisely the domain it prefers—as it hacked mostly Western governmental agencies and related organizations such as political think tanks and governmental subcontractors. In 2013, researchers from security firm Kaspersky unearthed MiniDuke, a sophisticated piece of malware that had taken hold of 60 government agencies, think tanks, and other high-profile organizations in 23 countries, including the US, Hungary, Ukraine, Belgium, and Portugal.

MiniDuke was notable for its odd combination of advanced programming and the gratuitous references to literature found embedded into its code. (It contained strings that alluded to Dante Alighieri’s Divine Comedy and to 666, the Mark of the Beast discussed in a verse from the Book of Revelation.) Written in assembly, employing multiple levels of encryption, and relying on hijacked Twitter accounts and automated Google searches to maintain stealthy communications with command-and-control servers, MiniDuke was among the most advanced pieces of malware found at the time.

It wasn’t immediately clear who was behind the mysterious malware—another testament to the stealth of its creators. In 2015, however, researchers linked MiniDuke—and seven other pieces of previously unidentified malware—to Cozy Bear. After a half-decade of lurking, the shadowy group was suddenly brought into the light of day.

Cozy Bear once again came to prominence the following year when researchers discovered the group (along with Fancy Bear, a separate Russian-state hacking group) inside the servers of the Democratic National Committee, looking for intelligence such as opposition research into Donald Trump, the Republican nominee for president at the time. The hacking group resurfaced in the days following Trump’s election victory that year with a major spear-phishing blitz that targeted dozens of organizations in government, military, defense contracting, media, and other industries.

One of Cozy Bear’s crowning achievements came in late 2020 with the discovery of an extensive supply chain attack that targeted customers of SolarWinds, the Austin, Texas, maker of network management tools. After compromising SolarWinds’ software build system, the hacking group pushed infected updates to roughly 18,000 customers. The hackers then used the updates to compromise nine federal agencies and about 100 private companies, White House officials have said.

Cozy Bear has remained active, with multiple campaigns coming to light in 2021, including one that used zero-day vulnerabilities to infect fully updated iPhones. Last year, the group devoted much of its time to hacks of Ukraine.

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rocket-report:-iran-reaches-orbit;-chinese-firm-achieves-impressive-landing-test

Rocket Report: Iran reaches orbit; Chinese firm achieves impressive landing test

First and second stages of Blue Origin's

Enlarge / First and second stages of Blue Origin’s “New Glenn” test vehicle.

Blue Origin

Welcome to Edition 6.28 of the Rocket Report! There’s a lot going on in the world of launch as always, but this week I want to take this space for a personal message. I have just announced the forthcoming publication of my second book, REENTRY, on the Falcon 9 rocket, Dragon spacecraft, and development of reusable launch. Full details here. I worked very hard to get the inside story.

As always, we welcome reader submissions, and if you don’t want to miss an issue, please subscribe using the box below (the form will not appear on AMP-enabled versions of the site). Each report will include information on small-, medium-, and heavy-lift rockets as well as a quick look ahead at the next three launches on the calendar.

Europe seeks to support small launch companies. The European Space Agency and European Commission have selected five launch companies to participate in a new program to provide flight opportunities for new technologies, a sign of a greater role the European Union intends to play in launch, Space News reports. The effort seeks to stimulate demand for European launch services by allowing companies to compete for missions in the European Union’s In-Orbit Demonstration and Validation technology program. Proposals for the program’s first phase are due to ESA at the end of February.

Getting a golden ticket … The agency expects to select up to three companies for initial contracts with a combined value of 75 million euros ($82 million) to begin design work on those vehicles. Four of the companies selected for the “Flight Ticket Initiative” are startups working on small launch vehicles: Isar Aerospace, Orbex, PLD Space, and Rocket Factory Augsburg. None of them has yet conducted an orbital launch, but they expect to do so within the next two years. The fifth company was Arianespace, which will offer rideshare launches on its Vega C and Ariane 6 rockets. (submitted by Ken the Bin and EllPeaTea)

Iran successfully launches Qaem 100 rocket. Iran said Saturday it had conducted a successful satellite launch into its highest orbit yet, the latest for a program the West fears improves Tehran’s ballistic missiles, the Associated Press reports. The Iranian Soraya satellite was placed in an orbit at some 750 kilometers (460 miles) above the Earth’s surface with its three-stage Qaem 100 rocket, the state-run IRNA news agency said. It did not immediately acknowledge what the satellite did, though telecommunications minister Isa Zarepour described the launch as having a 50-kilogram (110-pound) payload.

Qaem’s first orbital flight … The United States has previously said Iran’s satellite launches defy a UN Security Council resolution and called on Tehran to undertake no activity involving ballistic missiles capable of delivering nuclear weapons. UN sanctions related to Iran’s ballistic missile program expired last October. Iran has always denied seeking nuclear weapons and says its space program, like its nuclear activities, is for purely civilian purposes. This was the third launch of the Qaem rocket, which can loft up to 80 kg to low-Earth orbit. A suborbital test flight in 2022 was successful, but the first orbital attempt last March failed. (submitted by Ken the Bin)

The easiest way to keep up with Eric Berger’s space reporting is to sign up for his newsletter, we’ll collect his stories in your inbox.

Chinese firm tests vertical landing. Chinese launch startup Landspace executed a first vertical takeoff and vertical landing with a test article Friday at a launch and recovery site at Jiuquan spaceport, Space News reports. The methane-liquid oxygen test article reached an altitude of around 350 meters during its roughly 60-second flight before setting down in a designated landing area. The landing had an accuracy of about 2.4 meters and a landing speed of less than 1 meter per second, the company said.

Part Starship, part Falcon 9 … The test is part of the development of the stainless-steel Zhuque-3 rocket first announced in November 2023. The company is aiming for the first flight of Zhuque-3 next year. It is an ambitious project: The rocket is intended to have a payload capacity of 21 tons to low-Earth orbit in expendable mode, and 18.3 tons when the rocket is recovered downrange. If Zhuque-3 comes to pass—and these are promising early results—this would be the closest thing to a Falcon 9 rocket anyone has yet developed. (submitted by Ken the Bin)

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nasa-urged-astrobotic-not-to-send-its-hamstrung-spacecraft-toward-the-moon

NASA urged Astrobotic not to send its hamstrung spacecraft toward the Moon

A camera on Astrobotic's Peregrine spacecraft captured this view of a crescent Earth during its mission.

Enlarge / A camera on Astrobotic’s Peregrine spacecraft captured this view of a crescent Earth during its mission.

Astrobotic knew its first space mission would be rife with risks. After all, the company’s Peregrine spacecraft would attempt something never done before—landing a commercial spacecraft on the surface of the Moon.

The most hazardous part of the mission, actually landing on the Moon, would happen more than a month after Peregrine’s launch. But the robotic spacecraft never made it that far. During Peregrine’s startup sequence after separation from its United Launch Alliance Vulcan rocket, one of the spacecraft’s propellant tanks ruptured, spewing precious nitrogen tetroxide into space. The incident left Peregrine unable to land on the Moon, and it threatened to kill the spacecraft within hours of liftoff.

What a wild adventure we were just on, not the outcome we were hoping for,” said John Thornton, CEO of Astrobotic.

Astrobotic’s control team, working out of the company’s headquarters in Pittsburgh, swung into action to save the spacecraft. The propellant leak abated, and engineers wrestled control of the spacecraft to point its solar arrays toward the Sun, allowing its battery to recharge. Over time, Peregrine’s situation stabilized, although it didn’t have enough propellant remaining to attempt a descent to the lunar surface.

Peregrine continued on a trajectory out to 250,000 miles (400,000 kilometers) from Earth, about the same distance as the Moon’s orbit. Astrobotic’s original flight plan would have taken Peregrine on one long elliptical loop around Earth, then the spacecraft would have reached the Moon during its second orbit.

On its way back toward Earth, Peregrine was on a flight path that would bring it back into the atmosphere, where it would burn up on reentry. That meant Astrobotic had a decision to make. With Peregrine stabilized, should they attempt an engine burn to divert the spacecraft away from Earth onto a trajectory that could bring it to the vicinity of the Moon? Or should Astrobotic keep Peregrine in line to reenter Earth’s atmosphere and avoid the risk of sending a crippled spacecraft out to the Moon?

Making lemonade out of lemons

This was the first time Astrobotic had flown a space mission, and its control team had much to learn. The malfunction that caused the propellant leak appears to have been with a valve that did not properly reseat during the propulsion system’s initialization sequence. This valve activated to pressurize the fuel and oxidizer tanks with helium.

When the valve didn’t reseat, it sent a “rush of helium” into the oxidizer system, Thornton said. “I describe it as a rush because it was very, very fast. “Within a little over a minute, the pressure had risen to the point in the oxidizer side that it was well beyond the proof limit of the propulsion tank. We believe at that point the tank ruptured and led to, unfortunately, a catastrophic loss of propellant … for the primary mission.”

Thornton described the glum mood of Astrobotic’s team after the propellant leak.

“We were coming from the highest high of a perfect launch and came down to the lowest low, when we found out that the spacecraft no longer had the helium and no longer had the propulsion needed to attempt the Moon landing,” he said. “What happened next, I think, was pretty remarkable and inspiring.”

In a press briefing Friday, Thornton outlined the obstacles Astrobotic’s controllers overcame to keep Peregrine alive. Without a healthy propulsion system, the spacecraft’s solar panels were not pointed at the Sun. With a few minutes to spare, one of Astrobotic’s engineers, John Shaffer, devised a solution to reorient the spacecraft to start recharging its battery.

As Peregrine’s oxidizer tank lost pressure, the leak rate slowed. At first, it looked like the spacecraft might have only hours of propellant remaining. Then, Astrobotic reported on January 15 that the leak had “practically stopped.” Mission controllers powered up the science payloads aboard the Peregrine lander, proving the instruments worked and demonstrating the spacecraft could have returned data from the lunar surface if it landed.

The small propulsive impulse from the leaking oxidizer drove Peregrine slightly off course, putting it on a course to bring it back into Earth’s atmosphere. This set up Astrobotic for a “very difficult decision,” Thornton said.

Astrobotic's first lunar lander, named Peregrine, at the company's Pittsburgh headquarters.

Enlarge / Astrobotic’s first lunar lander, named Peregrine, at the company’s Pittsburgh headquarters.

Nudging Peregrine off its collision course with Earth would have required the spacecraft to fire its main engines, and even if that worked, the lander would have needed to perform more maneuvers to get close to the Moon. A landing was still out of the question, but Thornton said there was a small chance Astrobotic could have guided Peregrine toward a flyby or impact with the Moon.

“The thing we were weighing was, ‘Should we send this back to Earth, or should we take the risk to operate it in cislunar space and see if we can send this out farther?'” Thornton said.

NASA urged Astrobotic not to send its hamstrung spacecraft toward the Moon Read More »

top-harvard-cancer-researchers-accused-of-scientific-fraud;-37-studies-affected

Top Harvard Cancer researchers accused of scientific fraud; 37 studies affected

Lazy —

Researchers accused of manipulating data images with copy-and-paste.

The Dana-Farber Cancer Institute in Boston.

Enlarge / The Dana-Farber Cancer Institute in Boston.

The Dana-Farber Cancer Institute, an affiliate of Harvard Medical School, is seeking to retract six scientific studies and correct 31 others that were published by the institute’s top researchers, including its CEO. The researchers are accused of manipulating data images with simple methods, primarily with copy-and-paste in image editing software, such as Adobe Photoshop.

The accusations come from data sleuth Sholto David and colleagues on PubPeer, an online forum for researchers to discuss publications that has frequently served to spot dubious research and potential fraud. On January 2, David posted on his research integrity blog, For Better Science, a long list of potential data manipulation from DFCI researchers. The post highlighted many data figures that appear to contain pixel-for-pixel duplications. The allegedly manipulated images are of data such as Western blots, which are used to detect and visualize the presence of proteins in a complex mixture.

DFCI Research Integrity Officer Barrett Rollins told The Harvard Crimson that David had contacted DFCI with allegations of data manipulation in 57 DFCI-led studies. Rollins said that the institute is “committed to a culture of accountability and integrity,” and that “Every inquiry about research integrity is examined fully.”

The allegations are against: DFCI President and CEO Laurie Glimcher, Executive Vice President and COO William Hahn, Senior Vice President for Experimental Medicine Irene Ghobrial, and Harvard Medical School professor Kenneth Anderson.

The Wall Street Journal noted that Rollins, the integrity officer, is also a co-author on two of the studies. He told the outlet he is recused from decisions involving those studies.

Amid the institute’s internal review, Rollins said the institute identified 38 studies in which DFCI researchers are primarily responsible for potential manipulation. The institute is seeking retraction of six studies and is contacting scientific publishers to correct 31 others, totaling 37 studies. The one remaining study of the 38 is still being reviewed.

Of the remaining 19 studies identified by David, three were cleared of manipulation allegations, and 16 were determined to have had the data in question collected at labs outside of DFCI. Those studies are still under investigation, Rollins told The Harvard Crimson. “Where possible, the heads of all of the other laboratories have been contacted and we will work with them to see that they correct the literature as warranted,” Rollins wrote in a statement.

Despite finding false data and manipulated images, Rollins pressed that it doesn’t necessarily mean that scientific misconduct occurred and the institute has not yet made such a determination. The “presence of image discrepancies in a paper is not evidence of an author’s intent to deceive,” Rollins wrote. “That conclusion can only be drawn after a careful, fact-based examination which is an integral part of our response. Our experience is that errors are often unintentional and do not rise to the level of misconduct.”

The very simple methods used to manipulate the DFCI data are remarkably common among falsified scientific studies, however. Data sleuths have gotten better and better at spotting such lazy manipulations, including copied-and-pasted duplicates that are sometimes rotated and adjusted for size, brightness, and contrast. As Ars recently reported, all journals from the publisher Science now use an AI-powered tool to spot just this kind of image recycling because it is so common.

Top Harvard Cancer researchers accused of scientific fraud; 37 studies affected Read More »

megalodon-wasn’t-as-chonky-as-a-great-white-shark,-experts-say

Megalodon wasn’t as chonky as a great white shark, experts say

Still a pretty impressive size —

Fresh evidence points to megalodon being longer, more slender than previous depictions.

These are the kinds of shark teeth discovered in burial sites and other ceremonial remains of the inland Maya communities. From left to right, there's a fossilized megalodon tooth, great white shark tooth, and bull shark tooth.

Enlarge / These are the kinds of shark teeth discovered in burial sites and other ceremonial remains of the inland Maya communities. From left to right, there’s a fossilized megalodon tooth, great white shark tooth, and bull shark tooth.

Antiquity

The megalodon, a giant shark that went extinct some 3.6 million years ago, is famous for its utterly enormous jaws and correspondingly huge teeth. Recent studies have proposed that the megalodon was robust species of shark akin to today’s great white sharks, only three times longer. And just like the great white shark inspired Jaws, the megalodon has also inspired a 1997 novel and a blockbuster film (2018’s The Meg)—not to mention a controversial bit of “docu-fiction” on the Discovery Channel.  But now a team of 26 shark experts are challenging the great white shark comparison, arguing that the super-sized creature’s body was more slender and possibly even longer than researchers previously thought in a new paper published in the journal Paleontologia Electronica.

“Our study suggests that the modern great white shark may not necessarily serve as a good modern analogue for assessing at least certain aspects of its biology, including its size,” co-author Kenshu Shimada, a palaeobiologist at DePaul University in Chicago, told The Guardian. “The reality is that we need the discovery of at least one complete megalodon skeleton to be more confident about its true size as well its body form.” Thus far, nobody has found a complete specimen, only fossilized teeth and vertebrae.

As previously reported, the largest shark alive today, reaching up to 20 meters long, is the whale shark, a sedate filter feeder. As recently as 4 million years ago, however, sharks of that scale likely included the fast-moving predator megalodon (formally Otodus megalodon). Due to incomplete fossil data, we’re not entirely sure how large megalodons were and can only make inferences based on some of their living relatives, like the great white and mako sharks.

Thanks to research published last year on its fossilized teeth, we’re now fairly confident that it shared something else with these relatives: it wasn’t entirely cold-blooded and apparently kept its body temperature above that of the surrounding ocean. Most sharks, like most fish, are ectothermic, meaning that their body temperatures match those of the surrounding water. But a handful of species, part of a group termed mackerel sharks, are endothermic: They have a specialized pattern of blood circulation that helps retain some of the heat their muscles produce. This enables them to keep some body parts at a higher temperature than their surroundings. A species called the salmon shark can maintain a body temperature that’s 20° C warmer than the sub-Arctic waters that it occupies.

Megalodon is also a mackerel shark, and some scientists have suggested that it, too, must have been at least partially endothermic to have maintained its growth rates in the varied environments that it inhabited. The 2023 study measured isotope clumping—which can provide an estimate of the temperature at which a material formed—in mastodon teeth. They confirmed that the megalodon samples were consistently warmer, with an average temperature difference of about 7° C compared to cold-blooded samples.

Megalodon wasn’t as chonky as a great white shark, experts say Read More »

google-lays-off-“dozens”-from-x-labs,-wants-projects-to-seek-outside-funding

Google lays off “dozens” from X Labs, wants projects to seek outside funding

At least you don’t have to work on a Monday —

Google wants projects to take outside venture capital as part of budget cuts.

A large Google sign seen on a window of Google's headquarters.

Enlarge / Exterior view of a Googleplex building, the corporate headquarters of Google and parent company Alphabet, May 2018.

Google/Alphabet CEO Sundar Pichai wasn’t kidding when, earlier this month, he said more layoffs are coming. The latest group to be hit is Alphabet’s X Lab, which is losing “dozens of employees,” according to a new report from Bloomberg. This is something like the 11th Google layoff announcement we’ve covered in the past 12 months and the fourth one this month.

The X Lab is Alphabet’s “moonshot” experimental group, which is responsible for wild concepts like a wearable head-up display, a self-driving car, smart contact lenses, flying Internet balloons, and delivery drones. This is the age of Google cost-cutting, and you’ll notice none of those projects is a rip-roaring commercial success. On Google’s financials, the X Lab is part of Alphabet’s “Other Bets” group, which burns through around a billion dollars every quarter. It’s a research arm, so the hope is that spending all this money will someday lead to new revenue streams. For the short-term Wall Street types, though, it’s a money loser, quarter to quarter, and that makes it a prime candidate for cuts.

Bloomberg has a copy of the memo announcing the cuts to the X Labs staff, and there’s more in there than just layoffs. X Lab CEO Astro Teller writes: “We’re expanding our approach to focus on spinning out more projects as independent companies funded through market-based capital. We’ll do this by opening our scope to collaborate with a broader base of industry and financial partners, and by continuing to emphasize lean teams and capital efficiency.” Basically, Google wants these money losers to find their own funding somewhere else, at least partially.

The “outside funding” model isn’t new for some of Alphabet’s biggest and most promising “Other Bets” projects. The self-driving car company, Waymo, took rounds of outside funding in 2020 and 2021, racking up over $5 billion of cash that didn’t come from the Google Ads money geyser. Verily, Alphabet’s health care data analytics company, has also raised billions in outside funding. Both groups started as X projects and later “graduated” to full-fledged Alphabet companies. Others, like Project Loon (Internet balloons) and Sidewalk Infrastructure Partners (infrastructure planning), were X or Alphabet companies and were spun out as fully independent entities, separate from the Alphabet earnings sheet. Apparently, Alphabet wants to push X projects down one of those two paths.

On one hand, outside funding will result in a tougher, more critical eye for some of these projects. On the other hand, the Bloomberg report notes that “Alphabet could only accommodate so many Other Bets, creating a bottleneck for X ventures that were ready to take the next step, according to one of the people with knowledge of the matter. Startups within X often faced a choice between waiting for a spot to open up or striking out on their own.”

Google lays off “dozens” from X Labs, wants projects to seek outside funding Read More »

robocall-with-artificial-joe-biden-voice-tells-democrats-not-to-vote

Robocall with artificial Joe Biden voice tells Democrats not to vote

A bunch of malarkey —

Fake Biden voice urges New Hampshire Democrats to skip tomorrow’s primary.

Joe Biden holds a cell phone to his ear while having a conversation.

Enlarge / President Joe Biden at a Rose Garden event at the White House on May 1, 2023, in Washington, DC.

Getty Images | Alex Wong

An anti-voting robocall that seems to use an artificially generated version of President Joe Biden’s voice is being investigated by the New Hampshire Attorney General’s office. The calls sent on Sunday told Democrats to avoid voting in the Presidential Primary on January 23.

“Although the voice in the robocall sounds like the voice of President Biden, this message appears to be artificially generated based on initial indications,” the state AG’s office said in an announcement today. The recorded message appears “to be an unlawful attempt to disrupt the New Hampshire Presidential Primary Election and to suppress New Hampshire voters,” the announcement said.

The “Biden” voice in the recording (available with this NBC News article) sounds a bit off but perhaps could fool some people into thinking it came from the president.

“What a bunch of malarkey,” the voice says. “You know the value of voting Democratic when our votes count. It’s important that you save your vote for the November election. We’ll need your help in electing Democrats up and down the ticket. Voting this Tuesday only enables the Republicans in their quest to elect Donald Trump again. Your vote makes a difference in November, not this Tuesday.”

NBC News reported that a spokesperson for the Trump campaign said it had no connection to the fake Biden call. “Not us, we have nothing to do with it,” the spokesperson said.

Spoofed Caller ID

The apparently spoofed Caller ID displayed the personal cell phone number of “a prominent New Hampshire Democrat,” NBC News wrote. Biden’s national campaign manager, Julie Chavez Rodriguez, said the “campaign is actively discussing additional actions to take immediately,” according to NBC News.

Biden isn’t officially on the ballot in New Hampshire this week because of a dispute over scheduling between New Hampshire Democrats and the Democratic National Committee. But there’s a write-in campaign supporting Biden in the Democratic primary, and a spokesperson for the write-in campaign described the robocall as “deepfake disinformation designed to harm Joe Biden, suppress votes, and damage our democracy.”

The New Hampshire AG’s office said the fake Biden call “appears to have been ‘spoofed’ to falsely show that it had been sent by the treasurer of a political committee that has been supporting the New Hampshire Democratic Presidential Primary write-in efforts for President Biden. The message’s content directed recipients who wished to be removed from a calling list to call the number belonging to this person.”

The AG’s office pointed out that no law prevents someone from voting in both January and November. “Voting in the New Hampshire Presidential Primary Election does not preclude a voter from additionally voting in the November General Election,” the AG’s office said.

Robocall with artificial Joe Biden voice tells Democrats not to vote Read More »

meta-relents-to-eu,-allows-unlinking-of-facebook-and-instagram-accounts

Meta relents to EU, allows unlinking of Facebook and Instagram accounts

Meta relents to EU, allows unlinking of Facebook and Instagram accounts

Meta will allow some Facebook and Instagram users to unlink their accounts as part of the platform’s efforts to comply with the European Union’s Digital Markets Act (DMA) ahead of enforcement starting March 1.

In a blog, Meta’s competition and regulatory director, Tim Lamb, wrote that Instagram and Facebook users in the EU, the European Economic Area, and Switzerland would be notified in the “next few weeks” about “more choices about how they can use” Meta’s services and features, including new opportunities to limit data-sharing across apps and services.

Most significantly, users can choose to either keep their accounts linked or “manage their Instagram and Facebook accounts separately so that their information is no longer used across accounts.” Up to this point, linking user accounts had provided Meta with more data to more effectively target ads to more users. The perk of accessing data on Instagram’s widening younger user base, TechCrunch noted, was arguably the $1 billion selling point explaining why Facebook acquired Instagram in 2012.

Also announced today, users protected by the DMA will soon be able to separate their Facebook Messenger, Marketplace, and Gaming accounts. However, doing so will limit some social features available in some of the standalone apps.

While Messenger users choosing to disconnect the chat service from their Facebook accounts will still “be able to use Messenger’s core service offering such as private messaging and chat, voice and video calling,” Marketplace users making that same choice will have to email sellers and buyers, rather than using Facebook’s messenger service. And unlinked Gaming app users will only be able to play single-player games, severing their access to social gaming otherwise supported by linking the Gaming service to their Facebook social networks.

While Meta may have had choices other than depriving users unlinking accounts of some features, Meta didn’t really have a choice in allowing newly announced options to unlink accounts. The DMA specifically requires that very large platforms designated as “gatekeepers” give users the “specific choice” of opting out of sharing personal data across a platform’s different core services or across any separate services that the gatekeepers manage.

Without gaining “specific” consent, gatekeepers will no longer be allowed to “combine personal data from the relevant core platform service with personal data from any further core platform services” or “cross-use personal data from the relevant core platform service in other services provided separately by the gatekeeper,” the DMA says. The “specific” requirement is designed to block platforms from securing consent at sign-up, then hoovering up as much personal data as possible as new services are added in an endless pursuit of advertising growth.

As defined under the General Data Protection Regulation, the EU requiring “specific” consent stops platforms from gaining user consent for broadly defined data processing by instead establishing “the need for granularity,” so that platforms always seek consent for each “specific” data “processing purpose.”

“This is an important ‘safeguard against the gradual widening or blurring of purposes for which data is processed, after a data subject has agreed to the initial collection of the data,’” the European Data Protection Supervisor explained in public comments describing “commercial surveillance and data security practices that harm consumers” provided at the request of the FTC in 2022.

According to Meta’s help page, once users opt out of sharing data between apps and services, Meta will “stop combining your info across these accounts” within 15 days “after you’ve removed them.” However, all “previously combined info would remain combined.”

Meta relents to EU, allows unlinking of Facebook and Instagram accounts Read More »