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“it’s-shocking”:-massive-raw-milk-outbreak-from-2023-finally-reported

“It’s shocking”: Massive raw milk outbreak from 2023 finally reported


The outbreak occurred in 2023–2024, but little information had been shared about it.

On October 20, 2023, health officials in the County of San Diego, California, put out a press release warning of a Salmonella outbreak linked to raw (unpasteurized) milk. Such an outbreak is not particularly surprising; the reason the vast majority of milk is pasteurized (heated briefly to kill germs) is because milk can easily pick up nasty pathogens in the farmyard that can cause severe illnesses, particularly in children. It’s the reason public health officials have long and strongly warned against consuming raw milk.

At the time of the press release, officials in San Diego County had identified nine residents who had been sickened in the outbreak. Of those nine, three were children, and all three children had been hospitalized.

On October 25, the county put out a second press release, reporting that the local case count had risen to 12, and the suspected culprit—raw milk and raw cream from Raw Farm LLC—had been recalled. The same day, Orange County’s health department put out its own press release, reporting seven cases among its residents, including one in a 1-year-old infant.

Both counties noted that the California Department of Public Health (CDPH), which had posted the recall notice, was working on the outbreak, too. But it doesn’t appear that CDPH ever followed up with its own press release about the outbreak. The CDPH did write social media posts related to the outbreak: One on October 26, 2023, announced the recall; a second on November 30, 2023, noted “a recent outbreak” of Salmonella cases from raw milk but linked to general information about the risks of raw milk; and a third on December 7, 2023, linked to general information again with no mention of the outbreak.

But that seems to be the extent of the information at the time. For anyone paying attention, it might have seemed like the end of the story. But according to the final outbreak investigation report—produced by CDPH and local health officials—the outbreak actually ran from September 2023 to March 2024, spanned five states, and sickened at least 171 people. That report was released last week, on July 24, 2025.

Shocking outbreak

The report was published in the Morbidity and Mortality Weekly Report, a journal run by the Centers for Disease Control and Prevention. The report describes the outbreak as “one of the largest foodborne outbreaks linked to raw milk in recent US history.” It also said that the state and local health department had issued “extensive public messaging regarding this outbreak.”

According to the final data, of the 171 people, 120 (70 percent) were children and teens, including 67 (39 percent) who were under the age of 5. At least 22 people were hospitalized, nearly all of them (82 percent) were children and teens. Fortunately, there were no deaths.

“I was just candidly shocked that there was an outbreak of 170 plus people because it had not been reported—at all,” Bill Marler, a personal injury lawyer specializing in food poisoning outbreaks, told Ars Technica in an interview. With the large number of cases, the high percentage of kids, and cases in multiple states, “it’s shocking that they never publicized it,” he said. “I mean, what’s the point?”

Ars Technica reached out to CDPH seeking answers about why there wasn’t more messaging and information about the outbreak during and soon after the investigation. At the time this story was published, several business days had passed and the department had told Ars in a follow-up email that it was still working on a response. Shortly after publication, CDPH provided a written statement, but it did not answer any specific questions, including why CDPH did not release its own press release about the state-wide outbreak or make case counts public during the investigation.

“CDPH takes its charge to protect public health seriously and works closely with all partners when a foodborne illness outbreak is identified,” the statement reads. It then referenced only the social media posts and the press releases from San Diego County and Orange County mentioned previously in this story as examples of its public messaging.

“This is pissing me off”

Marler, who represents around two dozen of the 171 people sickened in the outbreak, was one of the first people to get the full picture of the outbreak from California officials. In July of 2024, he obtained an interim report of the investigation from state health officials. At that point, they had documented at least 165 of the cases. And in December 2024, he got access to a preliminary report of the full investigation dated October 15, 2024, which identified the final 171 cases and appears to contain much of the data published in the MMWR, which has had its publication rate slowed amid the second Trump administration.

Getting that information from California officials was not easy, Marler told Ars. “There was one point in time where they wouldn’t give it to me. And I sent them a copy of a subpoena and I said, ‘you know, I’ve been working with public health for 32 years. I’m a big supporter of public health. I believe in your mission, but,’ I said, ‘this is pissing me off.'”

At that point, Marler knew that it was a multi-county outbreak and the CDPH and the state’s Department of Food and Agriculture were involved. He knew there was data. But it took threatening a subpoena to get it. “I’m like ‘OK, you don’t give it to me. I’m going to freaking drop a subpoena on you, and the court’s going to force you to give it.’ And they’re like, ‘OK, we’ll give it to you.'”

The October 15 state report he finally got a hold of provides a breakdown of the California cases. It reports that San Diego had a total of 25 cases (not just the 12 initially reported in the press releases), and Orange County had 19 (not just the seven). Most of the other 171 cases were spread widely across California, spanning 35 local health departments. Only four of the 171 cases were outside of California—one each in New Mexico, Pennsylvania, Texas, and Washington. It’s unclear how people in these states were exposed, given that it’s against federal law to sell raw milk for human consumption across state lines. But two of the four people sickened outside of California specifically reported that they consumed dairy from Raw Farm without going to California.

Of the 171 cases, 159 were confirmed cases, which were defined as being confirmed using whole genome sequencing that linked the Salmonella strain causing a person’s infection to the outbreak strain also found in raw milk samples and a raw milk cheese sample from Raw Farm. The remaining 12 probable cases were people who had laboratory-confirmed Salmonella infections and also reported consuming Raw Farm products within seven days prior to falling ill.

“We own it”

In an interview with Ars Technica, the owner and founder of Raw Farm, Mark McAfee, disputed much of the information in the MMWR study and the October 2024 state report. He claimed that there were not 171 cases—only 19 people got sick, he said, presumably referring to the 19 cases collectively reported in the San Diego and Orange County press releases in October 2023.

“We own it. It’s ours. We’ve got these 19 people,” he told Ars.

But he said he did not believe that the genomic data was accurate and that the other 140 cases confirmed with genetic sequencing were not truly connected to his farm’s products. He also doubted that the outbreak spanned many months and into early 2024. McAfee says that a single cow that had been purchased close to the start of the outbreak had been the source of the Salmonella. Once that animal had been removed from the herd by the end of October 23, subsequent testing was negative. He also outright did not accept that testing identified the Salmonella outbreak strain in the farm’s raw cheese, which was reported in the MMWR and the state report.

Overall, McAfee downplayed the outbreak and claimed that raw milk has significant health benefits, such as being a cure for asthma—a common myth among raw milk advocates that has been debunked. He rejects the substantial number of scientific studies that have refuted the variety of unproven health claims made by raw-milk advocates. (You can read a thorough run-down of raw milk myths and the data refuting them in this post by the Food and Drug Administration.) McAfee claims that he and his company are “pioneers” and that public health experts who warn of the demonstrable health risks are simply stuck in the past.

Outbreak record

McAfee is a relatively high-profile raw milk advocate in California. For example, health secretary and anti-vaccine advocate Robert F. Kennedy Jr. is reportedly a customer. Amid an outbreak of H5N1 on his farm last year, McAfee sent Ars press material claiming that McAfee “has been asked by the RFK transition team to apply for the position of ‘FDA advisor on Raw Milk Policy and Standards Development.'” But McAfee’s opinion of Kennedy has soured since then. In an interview with Ars last week, he said Kennedy “doesn’t have the guts” to loosen federal regulations on raw milk.

On his blog, Marler has a running tally of at least 11 outbreaks linked to the farm’s products.

In this outbreak, illnesses were caused by Salmonella Typhimurium, which generally causes diarrhea, fever, vomiting, and abdominal pain. In some severe cases, the infection can spread outside the gastrointestinal tract and into the blood, brain, bones, and joints, according to the CDC.

Marler noted that, for kids, infections can be severe. “Some of these kids who got sick were hospitalized for extended periods of time,” he said of the some of the cases he is representing in litigation. And those hospitalizations can lead to hundreds of thousands of dollars in medical expenses, he said. “It’s not just tummy aches.”

This post has been updated to include the response from CDPH.

Photo of Beth Mole

Beth is Ars Technica’s Senior Health Reporter. Beth has a Ph.D. in microbiology from the University of North Carolina at Chapel Hill and attended the Science Communication program at the University of California, Santa Cruz. She specializes in covering infectious diseases, public health, and microbes.

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china-is-having-standard-flu-season-despite-widespread-hmpv-fears

China is having standard flu season despite widespread HMPV fears

There’s a good chance you’ve seen headlines about HMPV recently, with some touting “what you need to know” about the virus, aka human metapneumovirus. The answer is: not much.

It’s a common, usually mild respiratory virus that circulates every year, blending into the throng of other seasonal respiratory illnesses that are often indistinguishable from one another. (The pack includes influenza virus, respiratory syncytial virus (RSV), adenovirus, parainfluenza virus, common human coronaviruses, bocavirus, rhinovirus, enteroviruses, and Mycoplasma pneumoniae, among others.) HMPV is in the same family of viruses as RSV.

As one viral disease epidemiologist at the US Centers for Disease Control summarized in 2016, it’s usually “clinically indistinguishable” from other bog-standard respiratory illnesses, like seasonal flu, that cause cough, fever, and nasal congestion. For most, the infection is crummy but not worth a visit to a doctor. As such, testing for it is limited. But, like other common respiratory infections, it can be dangerous for children under age 5, older adults, and those with compromised immune systems. It was first identified in 2001, but it has likely been circulating since at least 1958.

The situation in China

The explosion of interest in HMPV comes after reports of a spike of HMPV infections in China, which allegedly led to hordes of masked patients filling hospitals. But none of that appears to be accurate. While HMPV infections have risen, the increase is not unusual for the respiratory illness season. Further, HMPV is not the leading cause of respiratory illnesses in China right now; the leading cause is seasonal flu. And the surge in seasonal flu is also within the usual levels seen at this time of year in China.

Last week, the Chinese Center for Disease Control and Prevention released its sentinel respiratory illness surveillance data collected in the last week of December. It included the test results of respiratory samples taken from outpatients. Of those, 30 percent were positive for flu (the largest share), a jump of about 6 percent from the previous week (the largest jump). Only 6 percent were positive for HMPV, which was about the same detection rate as in the previous week (there was a 0.1 percent increase).

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kamikaze-bacteria-explode-into-bursts-of-lethal-toxins

Kamikaze bacteria explode into bursts of lethal toxins

The needs of the many… —

If you make a big enough toxin, it’s difficult to get it out of the cells.

Colorized scanning electron microscope, SEM, image of Yersinia pestis bacteria

Enlarge / The plague bacteria, Yersina pestis, is a close relative of the toxin-producing species studied here.

Life-forms with no brain are capable of some astounding things. It might sound like sci-fi nightmare fuel, but some bacteria can wage kamikaze chemical warfare.

Pathogenic bacteria make us sick by secreting toxins. While the release of smaller toxin molecules is well understood, methods of releasing larger toxin molecules have mostly eluded us until now. Researcher Stefan Raunser, director of the Max Planck Institute of Molecular Physiology, and his team finally found out how the insect pathogen Yersinia entomophaga (which attacks beetles) releases its large-molecule toxin.

They found that designated “soldier cells” sacrifice themselves and explode to deploy the poison inside their victim. “YenTc appears to be the first example of an anti-eukaryotic toxin using this newly established type of secretion system,” the researchers said in a study recently published in Nature.

Silent and deadly

Y. entomophaga is part of the Yersinia genus, relatives of the plague bacteria, which produce what are known as Tc toxins. Their molecules are huge as far as bacterial toxins go, but, like most smaller toxin molecules, they still need to make it through the bacteria’s three cell membranes before they escape to damage the host. Raunser had already found in a previous study that Tc toxin molecules do show up outside the bacteria. What he wanted to see next was how and when they exit the bacteria that makes them.

To find out what kind of environment is ideal for Y. entomophaga to release YenTC, the bacteria were placed in acidic (PH under 7) and alkaline (PH over 7) mediums. While they did not release much in the acidic medium, the bacteria thrived in the high PH of the alkaline medium, and increasing the PH led it to release even more of the toxin. The higher PH environment in a beetle is around the mid-end of its gut, so it is now thought that most of the toxin is liberated when the bacteria reach that area.

How YenTc is released was more difficult to determine. When the research team used mass spectrometry to take a closer look at the toxin, they found that it was missing something: There was no signal sequence that indicated to the bacteria that the protein needed to be transported outside the bacterium. Signal sequences, also known as signal peptides, are kind of like built-in tags for secretion. They are in charge of connecting the proteins (toxins are proteins) to a complex at the innermost cell membrane that pushes them through. But YenTC apparently doesn’t need a signal sequence to export its toxins into the host.

About to explode

So how does this insect killer release YenTc, its most formidable toxin? The first test was a process of elimination. While YenTc has no signal sequence, the bacteria have different secretion systems for other toxins that it releases. Raunser thought that knocking out these secretion systems using gene editing could possibly reveal which one was responsible for secreting YenTc. Every secretion system in Y. entomophaga was knocked out until no more were left, yet the bacteria were still able to secrete YenTc.

The researchers then used fluorescence microscopy to observe the bacteria releasing its toxin. They inserted a gene that encodes a fluorescent protein into the toxin gene so the bacteria would glow when making the toxin. While not all Y. entomophaga cells produced YenTc, those that did (and so glowed) tended to be larger and more sluggish. To induce secretion, PH was raised to alkaline levels. Non-producing cells went about their business, but YenTc-expressing cells only took minutes to collapse and release the toxin.

This is what’s called a lytic secretion system, which involves the rupture of cell walls or membranes to release toxins.

“This prime example of self-destructive cooperation in bacteria demonstrates that YenTc release is the result of a controlled lysis strictly dedicated to toxin release rather than a typical secretion process, explaining our initially perplexing observation of atypical extracellular proteins,” the researchers said in the same study.

Yersinia also includes pathogenic bacteria that cause tuberculosis and bubonic plague, diseases that have devastated humans. Now that the secretion mechanism of one Yersinia species has been found out, Raunser wants to study more of them, along with other types of pathogens, to see if any others have kamikaze soldier cells that use the same lytic mechanism of releasing toxins.

The discovery of Y. entomophaga’s exploding cells could eventually mean human treatments that target kamikaze cells. In the meantime, we can at least be relieved we aren’t beetles.

Nature Microbiology, 2024. DOI: 10.1038/s41564-023-01571-z

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