chemistry

ancient-egyptians-likely-used-opiates-regularly

Ancient Egyptians likely used opiates regularly

Scientists have found traces of ancient opiates in the residue lining an Egyptian alabaster vase, indicating that opiate use was woven into the fabric of the culture. And the Egyptians didn’t just indulge occasionally: according to a paper published in the Journal of Eastern Mediterranean Archaeology, opiate use may have been a fixture of daily life.

In recent years, archaeologists have been applying the tools of pharmacology to excavated artifacts in collections around the world. As previously reported, there is ample evidence that humans in many cultures throughout history used various hallucinogenic substances in religious ceremonies or shamanic rituals. That includes not just ancient Egypt but also ancient Greek, Vedic, Maya, Inca, and Aztec cultures. The Urarina people who live in the Peruvian Amazon Basin still use a psychoactive brew called ayahuasca in their rituals, and Westerners seeking their own brand of enlightenment have also been known to participate.

For instance, in 2023, David Tanasi, of the University of South Florida, posted a preprint on his preliminary analysis of a ceremonial mug decorated with the head of Bes, a popular deity believed to confer protection on households, especially mothers and children. After collecting sample residues from the vessel, Tanasi applied various techniques—including proteomic and genetic analyses and synchrotron radiation-based Fourier-transform infrared microspectroscopy—to characterize the residues.

Tanasi found traces of Syrian rue, whose seeds are known to have hallucinogenic properties that can induce dream-like visions, per the authors, thanks to its production of the alkaloids harmine and harmaline. There were also traces of blue water lily, which contains a psychoactive alkaloid that acts as a sedative, as well as a fermented alcoholic concoction containing yeasts, wheat, sesame seeds, fruit (possibly grapes), honey, and, um, “human fluids”: possibly breast milk, oral or vaginal mucus, and blood. A follow-up 2024 study confirmed those results and also found traces of pine nuts or Mediterranean pine oil; licorice; tartaric acid salts that were likely part of the aforementioned alcoholic concoction; and traces of spider flowers known to have medicinal properties.

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neural-network-finds-an-enzyme-that-can-break-down-polyurethane

Neural network finds an enzyme that can break down polyurethane

You’ll often hear plastic pollution referred to as a problem. But the reality is that it’s multiple problems. Depending on the properties we need, we form plastics out of different polymers, each of which is held together by a distinct type of chemical bond. So the method we use to break down one type of polymer may be incompatible with the chemistry of another.

That problem is why, even though we’ve had success finding enzymes that break down common plastics like polyesters and PET, they’re only partial solutions to plastic waste. However, researchers aren’t sitting back and basking in the triumph of partial solutions, and they’ve now got very sophisticated protein design tools to help them out.

That’s the story behind a completely new enzyme that researchers developed to break down polyurethane, the polymer commonly used to make foam cushioning, among other things. The new enzyme is compatible with an industrial-style recycling process that breaks the polymer down into its basic building blocks, which can be used to form fresh polyurethane.

Breaking down polyurethane

Image of a set of chemical bonds. From left to right there is an X, then a single bond to an oxygen, then a single bond to an oxygen that's double-bonded to carbon, then a single bond to a nitrogen, then a single bond to another X.

The basics of the chemical bonds that link polyurethanes. The rest of the polymer is represented by X’s here.

The new paper that describes the development of this enzyme lays out the scale of the problem: In 2024, we made 22 million metric tons of polyurethane. The urethane bond that defines these involves a nitrogen bonded to a carbon that in turn is bonded to two oxygens, one of which links into the rest of the polymer. The rest of the polymer, linked by these bonds, can be fairly complex and often contains ringed structures related to benzene.

Digesting polyurethanes is challenging. Individual polymer chains are often extensively cross-linked, and the bulky structures can make it difficult for enzymes to get at the bonds they can digest. A chemical called diethylene glycol can partially break these molecules down, but only at elevated temperatures. And it leaves behind a complicated mess of chemicals that can’t be fed back into any useful reactions. Instead, it’s typically incinerated as hazardous waste.

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the-chemistry-behind-that-pricey-cup-of-civet-coffee

The chemistry behind that pricey cup of civet coffee

A sampling of scat

Kopi luwak is quite popular, with well-established markets in several South and East Asian countries. Its popularity has risen in Europe and the US as well, and India has recently become an emerging new market. Since there haven’t been similar studies of the chemical properties of kopi luwak from the Indian subcontinent, the authors of this latest study decided to fill that scientific gap. They focused on civet coffee produced in Kodagu, which produces nearly 36 percent of India’s total coffee production.

The authors collected 68 fresh civet scat samples from five different sites in Kodagu during peak fruit harvesting in January of this year. Collectors wore gloves to avoid contamination of the samples. For comparative analysis, they also harvested several bunches of ripened Robusta coffee berries. They washed the scat samples to remove the feces and also removed any palm seeds or other elements to ensure only Robusta beans remained.

For the manually harvested berries, the authors removed the pulp after a natural fermentation process and then sun-dried the beans for seven days. They then removed the hulls of both scat-derived and manually harvested berries and dried the beans in an oven for two hours. None of the bean samples were roasted, since roasting might significantly alter the acidity and chemical composition of the samples. For the chemical analysis, 10 distinct samples (five from each site where berries were collected) were ground into powder and subjected to various tests.

The civet beans had higher fat levels, particularly those compounds known to influence aroma and flavor, such as caprylic acid and methyl esters—contributing to kopi luwak’s distinctive aroma and flavor—but lower levels of caffeine, protein, and acidity, which would reduce the bitterness. The lower acidity is likely due to the coffee berries being naturally fermented in the civets’ digestive tracts, and there is more to learn about the role the gut microbiome plays in all of this. There were also several volatile organic compounds, common to standard coffee, that were extremely low or absent entirely in the civet samples.

In short, the comparative analysis “further supports the notion that civet coffee is chemically different from conventionally produced coffee of similar types, mainly due to fermentation,” the authors concluded. They recommend further research using roasted samples, along with studying other coffee varieties, samples from a more diverse selection of farms, and the influence of certain ecological conditions, such as canopy cover and the presence of wild trees.

Scientific Reports, 2025. DOI: 10.1038/s41598-025-21545-x  (About DOIs).

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building-ordered-polymers-with-metal

Building ordered polymers with metal

Unlike traditional polymers, this structure allows MOFs to have open internal spaces with a well-defined size, which can allow some molecules to pass through while filtering out others. In addition, the presence of metals provides for interesting chemistry. The metals can serve as catalysts or preferentially bind to one molecule within a mixture.

Knowing what we know now, it all seems kind of obvious that this would work. But when Robson started his work at the University of Melbourne, the few people who thought about the issue at all expected that the molecules he was building would be unstable and collapse.

The first MOF Robson built used copper as its metal of choice. It was linked to an organic molecule that retained its rigid structure through the presence of a benzene ring, which doesn’t bend. Both the organic molecule and the copper could form four different bonds, allowing the structure to grow by doing the rough equivalent of stacking a bunch of three-sided pyramids—a conscious choice by Robson.

Image of multiple triangular chemicals stacked on top of each other, forming a structure with lots of open internal spaces.

The world’s first MOF, synthesized by Robson and his colleagues. Credit: Johan Jarnestad/The Royal Swedish Academy of Sciences

In this case, however, the internal cavities remained filled by the solvent in which the MOF was formed. But the solvent could move freely through the material. Still, based on this example, Robson predicted many of the properties that have since been engineered into different MOFs: the ability to retain their structure even after solvents are removed, the presence of catalytic sites, and the ability of MOFs to act as filters.

Expanding the concept

All of that might seem a very optimistic take for someone’s first effort. But the measure of Robson’s success is that he convinced other chemists of the potential. One was Susumu Kitagawa of Kyoto University. Kitagawa and his collaborators built a MOF that had large internal channels that extended the entire length of the material. Made in a watery solution, the MOF could be dried out and have gas flow through it, with the structure retaining molecules like oxygen, nitrogen, and methane.

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meet-the-2025-ig-nobel-prize-winners

Meet the 2025 Ig Nobel Prize winners


The annual award ceremony features miniature operas, scientific demos, and the 24/7 lectures.

The Ig Nobel Prizes honor “achievements that first make people laugh and then make them think.” Credit: Aurich Lawson / Getty Images

Does alcohol enhance one’s foreign language fluency? Do West African lizards have a preferred pizza topping? And can painting cows with zebra stripes help repel biting flies? These and other unusual research questions were honored tonight in a virtual ceremony to announce the 2025 recipients of the annual Ig Nobel Prizes. Yes, it’s that time of year again, when the serious and the silly converge—for science.

Established in 1991, the Ig Nobels are a good-natured parody of the Nobel Prizes; they honor “achievements that first make people laugh and then make them think.” The unapologetically campy awards ceremony features miniature operas, scientific demos, and the 24/7 lectures whereby experts must explain their work twice: once in 24 seconds and the second in just seven words.

Acceptance speeches are limited to 60 seconds. And as the motto implies, the research being honored might seem ridiculous at first glance, but that doesn’t mean it’s devoid of scientific merit. In the weeks following the ceremony, the winners will also give free public talks, which will be posted on the Improbable Research website.

Without further ado, here are the winners of the 2025 Ig Nobel prizes.

Biology

Example of the area of legs and body used to count biting flies on cows.

Credit: Tomoki Kojima et al., 2019

Citation: Tomoki Kojima, Kazato Oishi, Yasushi Matsubara, Yuki Uchiyama, Yoshihiko Fukushima, Naoto Aoki, Say Sato, Tatsuaki Masuda, Junichi Ueda, Hiroyuki Hirooka, and Katsutoshi Kino, for their experiments to learn whether cows painted with zebra-like striping can avoid being bitten by flies.

Any dairy farmer can tell you that biting flies are a pestilent scourge for cattle herds, which is why one so often sees cows throwing their heads, stamping their feet, flicking their tails, and twitching their skin—desperately trying to shake off the nasty creatures. There’s an economic cost as well since it causes the cattle to graze and feed less, bed down for shorter times, and start bunching together, which increases heat stress and risks injury to the animals. That results in less milk yield for dairy cows and less beef yields from feedlot cattle.

You know who isn’t much bothered by biting flies? The zebra. Scientists have long debated the function of the zebra’s distinctive black-and-white striped pattern. Is it for camouflage? Confusing potential predators? Or is it to repel those pesky flies? Tomoki Kojima et al. decided to put the latter hypothesis to the test, painting zebra stripes on six pregnant Japanese black cows at the Aichi Agricultural Research Center in Japan. They used water-borne lacquers that washed away after a few days, so the cows could take turns being in three different groups: zebra stripes, just black stripes, or no stripes (as a control).

The results: the zebra stripes significantly decreased both the number of biting flies on the cattle and the animals’ fly-repelling behaviors compared to those with black stripes or no stripes. The one exception was for skin twitching—perhaps because it is the least energy intensive of those behaviors. Why does it work? The authors suggest it might have something to do with modulation brightness or polarized light that confuses the insects’ motion detection system, used to control their approach when landing on a surface. But that’s a topic for further study.

Chemistry

Freshly cooked frozen w:blintzes in a non-stick frying pan coated with Teflon

Credit: Andrevan/CC BY-SA 2.5

Citation: Rotem Naftalovich, Daniel Naftalovich, and Frank Greenway, for experiments to test whether eating Teflon [a form of plastic more formally called “polytetrafluoroethylene”] is a good way to increase food volume and hence satiety without increasing calorie content.

Diet sodas and other zero-calorie drinks are a mainstay of the modern diet, thanks to the development of artificial sweeteners whose molecules can’t be metabolized by the human body. The authors of this paper are intrigued by the notion of zero-calorie foods, which they believe could be achieved by increasing the satisfying volume and mass of food without increasing the calories. And they have just the additive for that purpose: polytetrafluoroethylene (PTFE), more commonly known as Teflon.

Yes, the stuff they use on nonstick cookware. They insist that Teflon is inert, heat-resistant, impervious to stomach acid, tasteless, cost-effective, and available in handy powder form for easy mixing into food. They recommend a ratio of three parts food to one part Teflon powder.

The authors understand that to the average layperson, this is going to sound like a phenomenally bad idea—no thank you, I would prefer not to have powdered Teflon added to my food. So they spend many paragraphs citing all the scientific studies on the safety of Teflon—it didn’t hurt rats in feeding trials!—as well as the many applications for which it is already being used. These include Teflon-coated stirring rods used in labs and coatings on medical devices like bladder catheters and gynecological implants, as well as the catheters used for in vitro fertilization. And guys, you’ll be happy to know that Teflon doesn’t seem to affect sperm motility or viability. I suspect this will still be a hard sell in the consumer marketplace.

Physics

Cacio e pepe is an iconic pasta dish that is also frustratingly difficult to make

Credit: Simone Frau

Citation: Giacomo Bartolucci, Daniel Maria Busiello, Matteo Ciarchi, Alberto Corticelli, Ivan Di Terlizzi, Fabrizio Olmeda, Davide Revignas, and Vincenzo Maria Schimmenti, for discoveries about the physics of pasta sauce, especially the phase transition that can lead to clumping, which can be a cause of unpleasantness.

“Pasta alla cacio e pepe” is a simple dish: just tonnarelli pasta, pecorino cheese, and pepper. But its simplicity is deceptive. The dish is notoriously challenging to make because it’s so easy for the sauce to form unappetizing clumps with a texture more akin to stringy mozzarella rather than being smooth and creamy. As we reported in April, Italian physicists came to the rescue with a foolproof recipe based on their many scientific experiments, according to a new paper published in the journal Physics of Fluids. The trick: using corn starch for the cheese and pepper sauce instead of relying on however much starch leaches into the boiling water as the pasta is cooked.

Traditionally, the chef will extract part of the water and starch solution—which is cooled to a suitable temperature to avoid clumping as the cheese proteins “denaturate”—and mix it with the cheese to make the sauce, adding the pepper last, right before serving. But the authors note that temperature is not the only factor that can lead to this dreaded “mozzarella phase.” If one tries to mix cheese and water without any starch, the clumping is more pronounced. There is less clumping with water containing a little starch, like water in which pasta has been cooked. And when one mixes the cheese with pasta water “risottata”—i.e., collected and heated in a pan so enough water evaporates that there is a higher concentration of starch—there is almost no clumping.

The authors found that the correct starch ratio is between 2 to 3 percent of the cheese weight. Below that, you get the clumping phase separation; above that, and the sauce becomes stiff and unappetizing as it cools. Pasta water alone contains too little starch. Using pasta water “risottata” may concentrate the starch, but the chef has less control over the precise amount of starch. So the authors recommend simply dissolving 4 grams of powdered potato or corn starch in 40 grams of water, heating it gently until it thickens and combining that gel with the cheese. They also recommend toasting the black pepper briefly before adding it to the mixture to enhance its flavors and aromas.

Engineering Design

Experimental set-up (a) cardboard enclosure (b) UV-C tube light (c) SMPS

Credit: Vikash Kumar and Sarthak Mittal

Citation: Vikash Kumar and Sarthak Mittal, for analyzing, from an engineering design perspective, “how foul-smelling shoes affects the good experience of using a shoe-rack.”

Shoe odor is a universal problem, even in India, according to the authors of this paper, who hail from Shiv Nadar University (SNU) in Uttar Pradesh. All that heat and humidity means people perspire profusely when engaging even in moderate physical activity. Add in a lack of proper ventilation and washing, and shoes become a breeding ground for odor-causing bacteria called Kytococcus sedentarius. Most Indians make use of shoe racks to store their footwear, and the odors can become quite intense in that closed environment.

Yet nobody has really studied the “smelly shoe” problem when it comes to shoe racks. Enter Kumar and Mittal, who conducted a pilot study with the help of 149 first-year SNU students. More than half reported feeling uncomfortable about their own or someone else’s smelly shoes, and 90 percent kept their shoes in a shoe rack. Common methods to combat the odor included washing the shoes and drying them in the sun; using spray deodorant; or sprinkling the shoes with an antibacterial powder. They were unaware of many current odor-combatting products on the market, such as tea tree and coconut oil solutions, thyme oil, or isopropyl alcohol.

Clearly, there is an opportunity to make a killing in the odor-resistant shoe rack market. So naturally Kumar and Mittal decided to design their own version. They opted to use bacteria-killing UV rays (via a UV-C tube light) as their built-in “odor eater,” testing their device on the shoes of several SNU athletes, “which had a very strong noticeable odor.” They concluded that an exposure time of two to three minutes was sufficient to kill the bacteria and get rid of the odor.

Aviation

Wing membranes (patagia) of Townsend's big-eared bat, Corynorhinus townsendii

Credit: Public domain

Citation: Francisco Sánchez, Mariana Melcón, Carmi Korine, and Berry Pinshow, for studying whether ingesting alcohol can impair bats’ ability to fly and also their ability to echolocate.

Nature is rife with naturally occurring ethanol, particularly from ripening fruit, and that fruit in turn is consumed by various microorganisms and animal species. There are occasional rare instances of some mammals, birds, and even insects consuming fruit rich in ethanol and becoming intoxicated, making those creatures more vulnerable to potential predators or more accident-prone due to lessened motor coordination. Sánchez et al. decided to look specifically at the effects of ethanol on Egyptian fruit bats, which have been shown to avoid high-ethanol fruit. The authors wondered if this might be because the bats wanted to avoid becoming inebriated.

They conducted their experiments on adult male fruit bats kept in an outdoor cage that served as a long flight corridor. The bats were given liquid food with varying amounts of ethanol and then released in the corridor, with the authors timing how long it took each bat to fly from one end to the other. A second experiment followed the same basic protocol, but this time the authors recorded the bats’ echolocation calls with an ultrasonic microphone. The results: The bats that received liquid food with the highest ethanol content took longer to fly the length of the corridor, evidence of impaired flight ability. The quality of those bats’ echolocation was also adversely affected, putting them at a higher risk of colliding with obstacles mid-flight.

Psychology

Narcissus (1597–99) by Caravaggio; the man in love with his own reflection

Credit: Public domain

Citation: Marcin Zajenkowski and Gilles Gignac, for investigating what happens when you tell narcissists—or anyone else—that they are intelligent.

Not all narcissists are created equal. There are vulnerable narcissists who tend to be socially withdrawn, have low self-esteem, and are prone to negative emotions. And then there are grandiose narcissists, who exhibit social boldness, high self-esteem, and are more likely to overestimate their own intelligence. The prevailing view is that this overconfidence stems from narcissism. The authors wanted to explore whether this effect might also work in reverse, i.e., that believing one has superior intelligence due to positive external feedback can lead to at least a temporary state of narcissism.

Zajenkowski et al. recruited 361 participants from Poland who were asked to rate their level of intelligence compared to other people; complete the Polish version of the Narcissistic Personality Inventory; and take an IQ test to compare their perceptions of their own intelligence with an objective measurement. The participants were then randomly assigned to one of two groups. One group received positive feedback—telling them they did indeed have a higher IQ than most people—while the other received negative feedback.

The results confirmed most of the researchers’ hypotheses. In general, participants gave lower estimates of their relative intelligence after completing the IQ test, which provided an objective check of sorts. But the type of feedback they received had a measurable impact. Positive feedback enhanced their feelings of uniqueness (a key aspect of grandiose narcissism). Those who received negative feedback rated their own intelligence as being lower, and that negative feedback had a larger effect than positive feedback. The authors concluded that external feedback helped shape the subjects’ perception of their own intelligence, regardless of the accuracy of that feedback.

Nutrition

Rainbow lizards eating ‘four cheese’ pizza at a seaside touristic resort in Togo.

Credit: Daniele Dendi et al, 2022

Citation: Daniele Dendi, Gabriel H. Segniagbeto, Roger Meek, and Luca Luiselli, for studying the extent to which a certain kind of lizard chooses to eat certain kinds of pizza.

Move over, Pizza Rat, here come the Pizza Lizards—rainbow lizards, to be precise. This is a species common to urban and suburban West Africa. The lizards primarily live off insects and arthropods, but their proximity to humans has led to some developing a more omnivorous approach to their foraging. Bread is a particular favorite. Case in point: One fine sunny day at a Togo seaside resort, the authors noticed a rainbow lizard stealing a tourist’s slice of four-cheese pizza and happily chowing down.

Naturally, they wanted to know if this was an isolated incident or whether the local rainbow lizards routinely feasted on pizza slices. And did the lizards have a preferred topping? Inquiring minds need to know. So they monitored the behavior of nine particular lizards, giving them the choice between a plate of four-cheese pizza and a plate of “four seasons” pizza, spaced about 10 meters apart.

It only took 15 minutes for the lizards to find the pizza and eat it, sometimes fighting over the remaining slices. But they only ate the four-cheese pizza. For the authors, this suggests there might be some form of chemical cues that attract them to the cheesy pizzas, or perhaps it’s easier for them to digest. I’d love to see how the lizards react to the widely derided Canadian bacon and pineapple pizza.

Pediatrics

Pumped breast milk in bottles

Citation: Julie Mennella and Gary Beauchamp, for studying what a nursing baby experiences when the baby’s mother eats garlic.

Mennella and Beauchamp designed their experiment to investigate two questions: whether the consumption of garlic altered the odor of a mother’s breast milk, and if so, whether those changes affected the behavior of nursing infants. (Garlic was chosen because it is known to produce off flavors in dairy cow milk and affect human body odor.) They recruited eight women who were exclusively breastfeeding their infants, taking samples of their breast milk over a period when the participants abstained from eating sulfurous foods (garlic, onion, asparagus), and more samples after the mothers consumed either a garlic capsule or a placebo.

The results: Mothers who ingested the garlic capsules produced milk with a perceptibly more intense odor, as evaluated by several adult panelists brought in to sniff the breast milk samples. The strong odor peaked at two hours after ingestion and decreased fats, which is consistent with prior research on cows that ingested highly odorous feeds. As for the infants, those whose mothers ingested garlic attached to the breast for longer periods and sucked more when the milk smelled like garlic. This could be relevant to ongoing efforts to determine whether sensory experiences during breastfeeding can influence how readily infants accept new foods upon weaning, and perhaps even their later food preferences.

Literature

closeup of a hand with clubbed fingernails

Credit: William B. Bean

Citation: The late Dr. William B. Bean, for persistently recording and analyzing the rate of growth of one of his fingernails over a period of 35 years.

If you’re surprised to see a study on fingernail growth rates under the Literature category, it will all make sense once you read the flowery prose stylings of Dr. Bean. He really did keep detailed records of how fast his fingernails grew for 35 years, claiming in his final report that “the nail provides a slowly moving keratin kymograph that measures age on the inexorable abscissa of time.” He sprinkles his observations with ponderous references to medieval astrology, James Boswell, and Moby Dick, with a dash of curmudgeonly asides bemoaning the sterile modern medical teaching methods that permeate “the teeming mass of hope and pain, technical virtuosity, and depersonalization called a ‘health center.'”

So what did our pedantic doctor discover in those 35 years, not just studying his own nails, but meticulously reviewing all the available scientific literature? Well, for starters, the rate of fingernail growth diminishes as one ages; Bean noted that his growth rates remained steady early on, but “slowed down a trifle” over the last five years of his project. Nails grow faster in children than adults. A warm environment can also accelerate growth, as does biting one’s fingernails—perhaps, he suggests, because the biting stimulates blood flow to the area. And he debunks the folklore of hair and nails growing even after death: it’s just the retraction and contraction of the skin post-mortem that makes it seem like the nails are growing.

Peace

Citation: Fritz Renner, Inge Kersbergen, Matt Field, and Jessica Werthmann, for showing that drinking alcohol sometimes improves a person’s ability to speak in a foreign language.

Alcohol is well-known to have detrimental effects on what’s known in psychological circles as “executive functioning,” impacting things like working memory and inhibitory control. But there’s a widespread belief among bilingual people that a little bit of alcohol actually improves one’s fluency in a foreign language, which also relies on executive functioning. So wouldn’t being intoxicated actually have an adverse effect on foreign language fluency? Renner et al. decided to investigate further.

They recruited 50 native German-speaking undergrad psychology students at Maastricht University in the Netherlands who were also fluent in Dutch. They were randomly divided into two groups. One group received an alcoholic drink (vodka with bitter lemon), and the other received water. Each participant consumed enough to be slightly intoxicated after 15 minutes, and then engaged in a discussion in Dutch with a native Dutch speaker. Afterward, they were asked to rate their self-perception of their skill at Dutch, with the Dutch speakers offering independent observer ratings.

The researchers were surprised to find that intoxication improved the participants’ Dutch fluency, based on the independent observer reports. (Self-evaluations were largely unaffected by intoxication levels.) One can’t simply attribute this to so-called “Dutch courage,” i.e., increased confidence associated with intoxication. Rather, the authors suggest that intoxication lowers language anxiety, thereby increasing one’s foreign language proficiency, although further research would be needed to support that hypothesis.

Photo of Jennifer Ouellette

Jennifer is a senior writer at Ars Technica with a particular focus on where science meets culture, covering everything from physics and related interdisciplinary topics to her favorite films and TV series. Jennifer lives in Baltimore with her spouse, physicist Sean M. Carroll, and their two cats, Ariel and Caliban.

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betel-nuts-have-been-giving-people-a-buzz-for-over-4,000-years

Betel nuts have been giving people a buzz for over 4,000 years

Ancient rituals and customs often leave behind obvious archaeological evidence. From the impeccably preserved mummies of Egypt to psychoactive substance residue that remained at the bottom of a clay vessel for thousands of years, it seems as if some remnants of the past, even if not all are immediately visible, have defied the ravages of time.

Chewing betel nuts is a cultural practice in parts of Southeast Asia. When chewed, these reddish nuts, which are the fruit of the areca palm, release psychoactive compounds that heighten alertness and energy, promote feelings of euphoria, and help with relaxation. They are usually wrapped in betel leaves with lime paste made from powdered shells or corals, depending on the region.

Critically, the ancient teeth from betel nut chewers are distinguishable because of red staining. So when archaeologist Piyawit Moonkham, of Chiang Mai University in Thailand, unearthed 4,000-year-old skeletons from the Bronze Age burial site of Nong Ratchawat, the lack of telltale red stains appeared to indicate that the individuals they belonged to were not chewers of betel nuts.

Yet when he sampled plaque from the teeth, he found that several of the teeth from one individual contained compounds found in betel nuts. This invisible evidence could indicate teeth cleaning practices had gotten rid of the color or that there were alternate methods of consumption.

“We found that these mineralized plaque deposits preserve multiple microscopic and biomolecular indicators,” Moonkham said in a study recently published in Frontiers. “This initial research suggested the detection potential for other psychoactive plant compounds.”

Since time immemorial

Betel nut chewing has been practiced in Thailand for at least 9,000 years. During the Lanna Kingdom, which began in the 13th century, teeth stained from betel chewing were considered a sign of beauty. While the practice is fading, it is still a part of some religious ceremonies, traditional medicine, and recreational gatherings, especially among certain ethnic minorities and people living in rural areas.

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this-aerogel-and-some-sun-could-make-saltwater-drinkable

This aerogel and some sun could make saltwater drinkable

Earth is about 71 percent water. An overwhelming 97 percent of that water is found in the oceans, leaving us with only 3 percent in the form of freshwater—and much of that is frozen in the form of glaciers. That leaves just 0.3 percent of that freshwater on the surface in lakes, swamps, springs, and our main sources of drinking water, rivers and streams.

Despite our planet’s famously blue appearance from space, thirsty aliens would be disappointed. Drinkable water is actually pretty scarce.

As if that doesn’t already sound unsettling, what little water we have is also threatened by climate change, urbanization, pollution, and a global population that continues to expand. Over 2 billion people live in regions where their only source of drinking water is contaminated. Pathogenic microbes in the water can cause cholera, diarrhea, dysentery, polio, and typhoid, which could be fatal in areas without access to vaccines or medical treatment.

Desalination of seawater is a possible solution, and one approach involves porous materials absorbing water that evaporates when heated by solar energy. The problem with most existing solar-powered evaporators is that they are difficult to scale up for larger populations. Performance decreases with size, because less water vapor can escape from materials with tiny pores and thick boundaries—but there is a way to overcome this.

Feeling salty

Researcher Xi Shen of the Hong Kong Polytechnic University wanted to figure out a way to improve these types of systems. He and his team have now created an aerogel that is far more efficient at turning over fresh water than previous methods of desalination.

“The key factors determining the evaporation performance of porous evaporators include heat localization, water transport, and vapor transport,” Shen said in a study recently published in ACS Energy Letters. “Significant advancements have been made in the structural design of evaporators to realize highly efficient thermal localization and water transport.”

Solar radiation is the only energy used to evaporate the water, which is why many attempts have been made to develop what are called photothermal materials. When sunlight hits these types of materials, they absorb light and convert it into heat energy, which can be used to speed up evaporation. Photothermal materials can be made of substances including polymers, metals, alloys, ceramics, or cements. Hydrogels have been used to successfully decontaminate and desalinate water before, but they are polymers designed to retain water, which negatively affects efficiency and stability, as opposed to aerogels, which are made of polymers that hold air. This is why Shen and his team decided to create a photothermal aerogel.

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rice-could-be-key-to-brewing-better-non-alcoholic-beer

Rice could be key to brewing better non-alcoholic beer

small glass of light colored beer with a nice foam head

Rice enhances flavor profiles for nonalcoholic beer, reduces fermentation time, and may contribute to flavor stability. Credit: Paden Johnson/CC BY-NC-SA

He and his team—including Christian Schubert, a visiting postdoc from the Research Institute for Raw Materials and Beverage Analysis in Berlin—brewed their own non-alcoholic beers, ranging from those made with 100 percent barley malt to ones made with 100 percent rice. They conducted a volatile chemical analysis to identify specific compounds present in the beers and assembled two sensory panels of tasters (one in the US, one in Europe) to assess aromas, flavors, and mouthfeel.

The panelists determined the rice-brewed beers had less worty flavors, and the chemical analysis revealed why: lower levels of aldehyde compounds. Instead, other sensory attributes emerged, most notably vanilla or buttery notes. “If a brewer wanted a more neutral character, they could use nonaromatic rice,” the authors wrote. Along with brewing beers with 50 percent barley/50 percent rice, this would produce non-alcoholic beers likely to appeal more broadly to consumers.

The panelists also noted that higher rice content resulted in beers with a fatty/creamy mouthfeel—likely because higher rice content was correlated with increased levels of larger alcohol molecules, which are known to contribute to a pleasant mouthfeel. But it didn’t raise the alcohol content above the legal threshold for a nonalcoholic beer.

There were cultural preferences, however. The US panelists didn’t mind worty flavors as much as the European tasters did, which might explain why the former chose beers brewed with 70 percent barley/30 percent rice as the optimal mix. Their European counterparts preferred the opposite ratio (30 percent barley/70 percent rice). The explanation “may lie in the sensory expectations shaped by each region’s brewing traditions,” the authors wrote. Fermentation also occurred more quickly as the rice content increased because of higher levels of glucose and fructose.

The second study focused on testing 74 different rice cultivars to determine their extract yields, an important variable when it comes to an efficient brewing process, since higher yields mean brewers can use less grain, thereby cutting costs. This revealed that cultivars with lower amylose content cracked more easily to release sugars during the mashing process, producing the highest yields. And certain varieties also had lower gelatinization temperatures for greater ease of processing.

International Journal of Food Science, 2025. DOI: 10.1080/10942912.2025.2520907  (About DOIs)

Journal of the American Society of Brewing Chemists, 2025. DOI: 10.1080/03610470.2025.2499768

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researchers-develop-a-battery-cathode-material-that-does-it-all

Researchers develop a battery cathode material that does it all

Battery electrode materials need to do a lot of things well. They need to be conductors to get charges to and from the ions that shuttle between the electrodes. They also need to have an open structure that allows the ions to move around before they reach a site where they can be stored. The storage of lots of ions also causes materials to expand, creating mechanical stresses that can cause the structure of the electrode material to gradually decay.

Because it’s hard to get all of these properties from a single material, many electrodes are composite materials, with one chemical used to allow ions into and out of the electrode, another to store them, and possibly a third that provides high conductivity. Unfortunately, this can create new problems, with breakdowns at the interfaces between materials slowly degrading the battery’s capacity.

Now, a team of researchers is proposing a material that seemingly does it all. It’s reasonably conductive, it allows lithium ions to move around and find storage sites, and it’s made of cheap and common elements. Perhaps best of all, it undergoes self-healing, smoothing out damage across charge/discharge cycles.

High capacity

The research team, primarily based in China, set out to limit the complexity of cathodes. “Conventional composite cathode designs, which typically incorporate a cathode active material, catholyte, and electronic conducting additive, are often limited by the substantial volume fraction of electrochemically inactive components,” the researchers wrote. The solution, they reasoned, was to create an all-in-one material that gets rid of most of these materials.

A number of papers had reported good luck with chlorine-based chemicals, which allowed ions to move readily through the material but didn’t conduct electricity very well. So the researchers experimented with pre-loading one of these materials with lithium. And they focused on iron chloride since it’s a very cheap material.

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a-guide-to-the-“platonic-ideal”-of-a-negroni-and-other-handy-tips

A guide to the “platonic ideal” of a Negroni and other handy tips


Perfumer by day, mixologist by night, Kevin Peterson specializes in crafting scent-paired cocktails.

Kevin Peterson is a “nose” for his own perfume company, Sfumato Fragrances, by day. By night, Sfumato’s retail store in Detroit transforms into Peterson’s craft cocktail bar, Castalia, where he is chief mixologist and designs drinks that pair with carefully selected aromas. He’s also the author of Cocktail Theory: A Sensory Approach to Transcendent Drinks, which grew out of his many (many!) mixology experiments and popular YouTube series, Objective Proof: The Science of Cocktails.

It’s fair to say that Peterson has had an unusual career trajectory. He worked as a line cook and an auto mechanic, and he worked on the production line of a butter factory, among other gigs, before attending culinary school in hopes of becoming a chef. However, he soon realized it wasn’t really what he wanted out of life and went to college, earning an undergraduate degree in physics from Carleton College and a PhD in mechanical engineering from the University of Michigan.

After 10 years as an engineer, he switched focus again and became more serious about his side hobby, perfumery. “Not being in kitchens anymore, I thought—this is a way to keep that little flavor part of my brain engaged,” Peterson told Ars. “I was doing problem sets all day. It was my escape to the sensory realm. ‘OK, my brain is melting—I need a completely different thing to do. Let me go smell smells, escape to my little scent desk.'” He and his wife, Jane Larson, founded Sfumato, which led to opening Castalia, and Peterson finally found his true calling.

Peterson spent years conducting mixology experiments to gather empirical data about the interplay between scent and flavor, correct ratios of ingredients, temperature, and dilution for all the classic cocktails—seeking a “Platonic ideal,” for each, if you will. He supplemented this with customer feedback data from the drinks served at Castalia. All that culminated in Cocktail Theory, which delves into the chemistry of scent and taste, introducing readers to flavor profiles, textures, visual presentation, and other factors that contribute to one’s enjoyment (or lack thereof) of a cocktail. And yes, there are practical tips for building your own home bar, as well as recipes for many of Castalia’s signature drinks.

In essence, Peterson’s work adds scientific rigor to what is frequently called the “Mr. Potato Head” theory of cocktails, a phrase coined by the folks at Death & Company, who operate several craft cocktail bars in key cities. “Let’s say you’ve got some classic cocktail, a daiquiri, that has this many parts of rum, this many parts of lime, this many parts of sugar,” said Peterson, who admits to having a Mr. Potato Head doll sitting on Castalia’s back bar in honor of the sobriquet. “You can think about each ingredient in a more general way: instead of rum, this is the spirit; instead of lime, this is the citrus; sugars are sweetener. Now you can start to replace those things with other things in the same categories.”

We caught up with Peterson to learn more.

Ars Technica: How did you start thinking about the interplay between perfumery and cocktail design and the role that aroma plays in each?

Kevin Peterson: The first step was from food over to perfumery, where I think about building a flavor for a soup, for a sauce, for a curry, in a certain way. “Oh, there’s a gap here that needs to be filled in by some herbs, some spice.” It’s almost an intuitive kind of thing. When I was making scents, I had those same ideas: “OK, the shape of this isn’t quite right. I need this to roughen it up or to smooth out this edge.”

Then I did the same thing for cocktails and realized that those two worlds didn’t really talk to each other. You’ve got two groups of people that study all the sensory elements and how to create the most intriguing sensory impression, but they use different language; they use different toolkits. They’re going for almost the same thing, but there was very little overlap between the two. So I made that my niche: What can perfumery teach bartenders? What can the cocktail world teach perfumery?

Ars Technica: In perfumery you talk about a top, a middle, and a base note. There must be an equivalent in cocktail theory?

Kevin Peterson: In perfumery, that is mostly talking about the time element: top notes perceived first, then middle notes, then base notes as you wear it over the course of a few hours. In the cocktail realm, there is that time element as well. You get some impression when you bring the glass to your nose, something when you sip, something in the aftertaste. But there can also be a spatial element. Some things you feel right at the tip of your tongue, some things you feel in different parts of your face and head, whether that’s a literal impression or you just kind of feel it somewhere where there’s not a literal nerve ending. It’s about filling up that space, or not filling it up, depending on what impression you’re going for—building out the full sensory space.

Ars Technica: You also talk about motifs and supportive effects or ornamental flourishes: themes that you can build on in cocktails.

Kevin Peterson: Something I see in the cocktail world occasionally is that people just put a bunch of ingredients together and figure, “This tastes fine.” But what were you going for here? There are 17 things in here, and it just kind of tastes like you were finger painting: “Hey, I made brown.” Brown is nice. But the motifs that I think about—maybe there’s just one particular element that I want to highlight. Say I’ve got this really great jasmine essence. Everything else in the blend is just there to highlight the jasmine.

If you’re dealing with a really nice mezcal or bourbon or some unique herb or spice, that’s going to be the centerpiece. You’re not trying to get overpowered by some smoky scotch, by some other more intense ingredient. The motif could just be a harmonious combination of elements. I think the perfect old-fashioned is where everything is present and nothing’s dominating. It’s not like the bitters or the whiskey totally took over. There’s the bitters, there’s a little bit of sugar, there’s the spirit. Everything’s playing nicely.

Another motif, I call it a jazz note. A Sazerac is almost the same as an old-fashioned, but it’s got a little bit of absinthe in it. You get all the harmony of the old-fashioned, but then you’re like, “Wait, what’s this weird thing pulling me off to the side? Oh, this absinthe note is kind of separate from everything else that’s going on in the drink.” It’s almost like that tension in a musical composition: “Well, these notes sound nice, but then there’s one that’s just weird.” But that’s what makes it interesting, that weird note. For me, formalizing some of those motifs help me make it clearer. Even if I don’t tell that to the guest during the composition stage, I know this is the effect I’m going for. It helps me build more intentionally when I’ve got a motif in mind.

Ars Technica: I tend to think about cocktails more in terms of chemistry, but there are many elements to taste and perception and flavor. You talk about ingredient matching, molecular matching, and impression matching, i.e., how certain elements will overlap in the brain. What role do each of those play?

Kevin Peterson: A lot of those ideas relate to how we pair scents with cocktails. At my perfume company, we make eight fragrances as our main line. Each scent then gets a paired drink on the cocktail menu. For example, this scent has coriander, cardamom, and nutmeg. What does it mean that the drink is paired with that? Does it need to literally have coriander, cardamom, and nutmeg in it? Does it need to have every ingredient? If the scent has 15 things, do I need to hit every note?

chart with sad neutral and happy faces showing the optimal temperature and dilution for a dauquiri

Peterson made over 100 daiquiris to find the “Platonic ideal” of the classic cocktail Credit: Kevin Peterson

The literal matching is the most obvious. “This has cardamom, that has cardamom.” I can see how that pairs. The molecular matching is essentially just one more step removed: Rosemary has alpha-pinene in it, and juniper berries have alpha-pinene in them. So if the scent has rosemary and the cocktail has gin, they’re both sharing that same molecule, so it’s still exciting that same scent receptor. What I’m thinking about is kind of resonant effects. You’re approaching the same receptor or the same neural structure in two different ways, and you’re creating a bigger peak with that.

The most hand-wavy one to me is the impression matching. Rosemary smells cold, and Fernet-Branca tastes cold even when it’s room temperature. If the scent has rosemary, is Fernet now a good match for that? Some of the neuroscience stuff that I’ve read has indicated that these more abstract ideas are represented by the same sort of neural-firing patterns. Initially, I was hesitant; cold and cold, it doesn’t feel as fulfilling to me. But then I did some more reading and realized there’s some science behind it and have been more intrigued by that lately.

Ars Technica: You do come up with some surprising flavor combinations, like a drink that combined blueberry and horseradish, which frankly sounds horrifying. 

Kevin Peterson: It was a hit on the menu. I would often give people a little taste of the blueberry and then a little taste of the horseradish tincture, and they’d say, “Yeah, I don’t like this.” And then I’d serve them the cocktail, and they’d be like, “Oh my gosh, it actually worked. I can’t believe it.”  Part of the beauty is you take a bunch of things that are at least not good and maybe downright terrible on their own, and then you stir them all together and somehow it’s lovely. That’s basically alchemy right there.

Ars Technica: Harmony between scent and the cocktail is one thing, but you also talk about constructive interference to get a surprising, unexpected, and yet still pleasurable result.

Kevin Peterson: The opposite is destructive interference, where there’s just too much going on. When I’m coming up with a drink, sometimes that’ll happen, where I’m adding more, but the flavor impression is going down. It’s sort of a weird non-linearity of flavor, where sometimes two plus two equals four, sometimes it equals three, sometimes it equals 17. I now have intuition about that, having been in this world for a lot of years, but I still get surprised sometimes when I put a couple things together.

Often with my end-of-the-shift drink, I’ll think, “Oh, we got this new bottle in. I’m going to try that in a Negroni variation.” Then I lose track and finish mopping, and then I sip, and I’m like, “What? Oh my gosh, I did not see this coming at all.” That little spark, or whatever combo creates that, will then often be the first step on some new cocktail development journey.

man's torso in a long-sleeved button down white shirt, with a small glass filled with juniper berries in front of him

Pairing scents with cocktails involves experimenting with many different ingredients Credit: EE Berger

Ars Technica: Smoked cocktails are a huge trend right now. What’s the best way to get a consistently good smoky element?

Kevin Peterson: Smoke is tricky to make repeatable. How many parts per million of smoke are you getting in the cocktail? You could standardize the amount of time that it’s in the box [filled with smoke]. Or you could always burn, say, exactly three grams of hickory or whatever. One thing that I found, because I was writing the book while still running the bar: People have a lot of expectations around how the drink is going to be served. Big ice cubes are not ideal for serving drinks, but people want a big ice cube in their old-fashioned. So we’re still using big ice cubes. There might be a Platonic ideal in terms of temperature, dilution, etc., but maybe it’s not the ideal in terms of visuals or tactile feel, and that is a part of the experience.

With the smoker, you open the doors, smoke billows out, your drink emerges from the smoke, and people say, “Wow, this is great.” So whether you get 100 PPM one time and 220 PPM the next, maybe that gets outweighed by the awesomeness of the presentation. If I’m trying to be very dialed in about it, I’ll either use a commercial smoky spirit—Laphroaig scotch, a smoky mezcal—where I decide that a quarter ounce is the amount of smokiness that I want in the drink. I can just pour the smoke instead of having to burn and time it.

Or I might even make my own smoke: light something on fire and then hold it under a bottle, tip it back up, put some vodka or something in there, shake it up. Now I’ve got smoke particles in my vodka. Maybe I can say, “OK, it’s always going to be one milliliter,” but then you miss out on the presentation—the showmanship, the human interaction, the garnish. I rarely garnish my own drinks, but I rarely send a drink out to a guest ungarnished, even if it’s just a simple orange peel.

Ars Technica: There’s always going to be an element of subjectivity, particularly when it comes to our sensory perceptions. Sometimes you run into a person who just can’t appreciate a certain note.

Kevin Peterson: That was something I grappled with. On the one hand, we’re all kind of living in our own flavor world. Some people are more sensitive to bitter. Different scent receptors are present in different people. It’s tempting to just say, “Well, everything’s so unique. Maybe we just can’t say anything about it at all.” But that’s not helpful either. Somehow, we keep having delicious food and drink and scents that come our way.

A sample page from Cocktail Theory discussing temperature and dilution

A sample page from Cocktail Theory discussing temperature and dilution. Credit: EE Berger

I’ve been taking a lot of survey data in my bar more recently, and definitely the individuality of preference has shown through in the surveys. But another thing that has shown through is that there are some universal trends. There are certain categories. There’s the spirit-forward, bittersweet drinkers, there’s the bubbly citrus folks, there’s the texture folks who like vodka soda. What is the taste? What is the aroma? It’s very minimal, but it’s a very intense texture. Having some awareness of that is critical when you’re making drinks.

One of the things I was going for in my book was to find, for example, the platonically ideal gin and tonic. What are the ratios? What is the temperature? How much dilution to how much spirit is the perfect amount? But if you don’t like gin and tonics, it doesn’t matter if it’s a platonically ideal gin and tonic. So that’s my next project. It’s not just getting the drink right. How do you match that to the right person? What questions do I have to ask you, or do I have to give you taste tests? How do I draw that information out of the customer to determine the perfect drink for them?

We offer a tasting menu, so our full menu is eight drinks, and you get a mini version of each drink. I started giving people surveys when they would do the tasting menu, asking, “Which drink do you think you like the most? Which drink do you think you like the least?” I would have them rate it. Less than half of people predicted their most liked and least liked, meaning if you were just going to order one drink off the menu, your odds are less than a coin flip that you would get the right drink.

Ars Technica: How does all this tie into your “cocktails as storytelling” philosophy? 

Kevin Peterson: So much of flavor impression is non-verbal. Scent is very hard to describe. You can maybe describe taste, but we only have five-ish words, things like bitter, sour, salty, sweet. There’s not a whole lot to say about that: “Oh, it was perfectly balanced.” So at my bar, when we design menus, we’ll put the drinks together, but then we’ll always give the menu a theme. The last menu that we did was the scientist menu, where every drink was made in honor of some scientist who didn’t get the credit they were due in the time they were alive.

Having that narrative element, I think, helps people remember the drink better. It helps them in the moment to latch onto something that they can more firmly think about. There’s a conceptual element. If I’m just doing chores around the house, I drink a beer, it doesn’t need to have a conceptual element. If I’m going out and spending money and it’s my night and I want this to be a more elevated experience, having that conceptual tie-in is an important part of that.

two martini glasses side by side with a cloudy liquid in them a bright red cherry at the bottom of the glass

My personal favorite drink, Corpse Reviver No. 2, has just a hint of absinthe. Credit: Sean Carroll

Ars Technica: Do you have any simple tips for people who are interested in taking their cocktail game to the next level?

Kevin Peterson:  Old-fashioneds are the most fragile cocktail. You have to get all the ratios exactly right. Everything has to be perfect for an old-fashioned to work. Anecdotally, I’ve gotten a lot of old-fashioneds that were terrible out on the town. In contrast, the Negroni is the most robust drink. You can miss the ratios. It’s got a very wide temperature and dilution window where it’s still totally fine. I kind of thought of them in the same way prior to doing the test. Then I found that this band of acceptability is much bigger for the Negroni. So now I think of old-fashioneds as something that either I make myself or I order when I either trust the bartender or I’m testing someone who wants to come work for me.

My other general piece of advice: It can be a very daunting world to try to get into. You may say, “Oh, there’s all these classics that I’m going to have to memorize, and I’ve got to buy all these weird bottles.” My advice is to pick a drink you like and take baby steps away from that drink. Say you like Negronis. That’s three bottles: vermouth, Campari, and gin. Start with that. When you finish that bottle of gin, buy a different type of gin. When you finish the Campari, try a different bittersweet liqueur. See if that’s going to work. You don’t have to drop hundreds of dollars, thousands of dollars, to build out a back bar. You can do it with baby steps.

Photo of Jennifer Ouellette

Jennifer is a senior writer at Ars Technica with a particular focus on where science meets culture, covering everything from physics and related interdisciplinary topics to her favorite films and TV series. Jennifer lives in Baltimore with her spouse, physicist Sean M. Carroll, and their two cats, Ariel and Caliban.

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researchers-engineer-bacteria-to-produce-plastics

Researchers engineer bacteria to produce plastics

Image of a series of chemical reactions, with enzymes driving each step forward.

One of the enzymes used in this system takes an amino acid (left) and links it to Coenzyme A. The second takes these items and links them into a polymer. Credit: Chae et. al.

Normally, PHA synthase forms links between molecules that run through an oxygen atom. But it’s also possible to form a related chemical link that instead runs through a nitrogen atom, like those found on amino acids. There were no known enzymes, however, that catalyze these reactions. So, the researchers decided to test whether any existing enzymes could be induced to do something they don’t normally do.

The researchers started with an enzyme from Clostridium that links chemicals to Coenzyme A that has a reputation for not being picky about the chemicals it interacts with. This worked reasonably well at linking amino acids to Coenzyme A. For linking the amino acids together, they used an enzyme from Pseudomonas that had four different mutations that expanded the range of molecules it would use as reaction materials. Used in a test tube, the system worked: Amino acids were linked together in a polymer.

The question was whether it would work in cells. Unfortunately, one of the two enzymes turns out to be mildly toxic to E. coli, slowing its growth. So, the researchers evolved a strain of E. coli that could tolerate the protein. With both of these two proteins, the cells produced small amounts of an amino acid polymer. If they added an excess of an amino acid to the media the cells were growing in, the polymer would be biased toward incorporating that amino acid.

Boosting polymer production

However, the yield of the polymer by weight of bacteria was fairly low. “It was reasoned that these [amino acids] might be more efficiently incorporated into the polymer if generated within the cells from a suitable carbon source,” the researchers write. So, the researchers put in extra copies of the genes needed to produce one specific amino acid (lysine). That worked, producing more polymer, with a higher percentage of the polymer being lysine.

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small-charges-in-water-spray-can-trigger-the-formation-of-key-biochemicals

Small charges in water spray can trigger the formation of key biochemicals

Once his team nailed how droplets become electrically charged and how the micro-lightning phenomenon works, they recreated the Miller-Urey experiment. Only without the spark plugs.

Ingredients of life

After micro-lightnings started jumping between droplets in a mixture of gases similar to that used by Miller and Urey, the team examined their chemical composition with a mass spectrometer. They confirmed glycine, uracil, urea, cyanoethylene, and lots of other chemical compounds were made. “Micro-lightnings made all organic molecules observed previously in the Miller-Urey experiment without any external voltage applied,” Zare claims.

But does it really bring us any closer to explaining the beginnings of life? After all, Miller and Urey already demonstrated those molecules could be produced by electrical discharges in a primordial Earth’s atmosphere—does it matter all that much where those discharges came from?  Zare argues that it does.

“Lightning is intermittent, so it would be hard for these molecules to concentrate. But if you look at waves crashing into rocks, you can think the spray would easily go into the crevices in these rocks,” Zare suggests. He suggests that the water in these crevices would evaporate, new spray would enter and evaporate again and again. The cyclic drying would allow the chemical precursors to build into more complex molecules. “When you go through such a dry cycle, it causes polymerization, which is how you make DNA,” Zare argues. Since sources of spray were likely common on the early Earth, Zare thinks this process could produce far more organic chemicals than potential alternatives like lightning strikes, hydrothermal vents, or impacting comets.

But even if micro-lightning really produced the basic building blocks of life on Earth, we’re still not sure how those combined into living organisms. “We did not make life. We just demonstrated a possible mechanism that gives us some chemical compounds you find in life,” Zare says. “It’s very important to have a lot of humility with this stuff.”

Science Advances, 2025.  DOI: 10.1126/sciadv.adt8979

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