health

controversial-fluoride-analysis-published-after-years-of-failed-reviews

Controversial fluoride analysis published after years of failed reviews


70 percent of studies included in the meta-analysis had a high risk of bias.

Federal toxicology researchers on Monday finally published a long-controversial analysis that claims to find a link between high levels of fluoride exposure and slightly lower IQs in children living in areas outside the US, mostly in China and India. As expected, it immediately drew yet more controversy.

The study, published in JAMA Pediatrics, is a meta-analysis, a type of study that combines data from many different studies—in this case, mostly low-quality studies—to come up with new results. None of the data included in the analysis is from the US, and the fluoride levels examined are at least double the level recommended for municipal water in the US. In some places in the world, fluoride is naturally present in water, such as parts of China, and can reach concentrations several-fold higher than fluoridated water in the US.

The authors of the analysis are researchers at the National Toxicology Program at the National Institute of Environmental Health Sciences. For context, this is the same federal research program that published a dubious analysis in 2016 suggesting that cell phones cause cancer in rats. The study underwent a suspicious peer-review process and contained questionable methods and statistics.

The new fluoride analysis shares similarities. NTP researchers have been working on the fluoride study since 2015 and submitted two drafts for peer review to an independent panel of experts at the National Academies of Sciences, Engineering, and Medicine in 2020 and 2021. The study failed its review both times. The National Academies’ reviews found fault with the methods and statistical rigor of the analysis. Specifically, the reviews noted potential bias in the selection of the studies included in the analysis, inconsistent application of risk-of-bias criteria, lack of data transparency, insufficient evaluations of potential confounding, and flawed measures of neurodevelopmental outcomes, among other problems.

After the failing reviews, the NTP selected its own reviewers and self-published the study as a monograph in August.

High risk of bias

The related analysis published Monday looked at data from 74 human studies, 45 of which were conducted in China and 12 in India. Of the 74, 52 were rated as having a high risk of bias, meaning they had designs, study methods, or statistical approaches that could skew the results.

The study’s primary meta-analysis only included 59 of the studies: 47 with a high risk of bias and 12 with a low risk. This analysis looked at standardized mean differences in children’s IQ between higher and lower fluoride exposure groups. Of the 59 studies, 41 were from China.

Among the 47 studies with a high risk of bias, the pooled difference in mean IQ scores between the higher-exposure groups and lower-exposure groups was -0.52, suggesting that higher fluoride exposure lowered IQs. But, among the 12 studies at low risk for bias, the difference was slight overall, only -0.19. And of those 12 studies, eight found no link between fluoride exposure and IQ at all.

Among 31 studies that reported fluoride levels in water, the NTP authors looked at possible IQ associations at three fluoride-level cutoffs: less than 4 mg/L, less than 2 mg/L, and less than 1.5 mg/L. Among all 31 studies, the researchers found that fluoride exposure levels of less than 4 mg/L and less than 2 mg/L were linked to statistically significant decreases in IQ. However, there was no statistically significant link at 1.5 mg/L. For context, 1.5 mg/L is a little over twice the level of fluoride recommended by the US Environmental Protection Agency for US community water, which is 0.7 mg/L. When the NTP authors looked at just the studies that had a low risk of bias—seven studies—they saw the same lack of association with the 1.5 mg/L cutoff.

The NTP authors also looked at IQ associations in 20 studies that reported urine fluoride levels and again split the analysis using the same fluoride cutoffs as before. While there did appear to be a link with lower IQ at the highest fluoride level, the two lower fluoride levels had borderline statistical significance. Ten of the 20 studies were assessed as having a low risk of bias, and for just those 10, the results were similar to the larger group.

Criticism

The inclusion of urinary fluoride measurements is sure to spark criticism. For years, experts have noted that these measurements are not standardized, can vary by day and time, and are not reflective of a person’s overall fluoride exposure.

In an editorial published alongside the NTP study today, Steven Levy, a public health dentist at the University of Iowa, blasted the new analysis, including the urinary sample measurements.

“There is scientific consensus that the urinary sample collection approaches used in almost all included studies (ie, spot urinary fluoride or a few 24-hour samples, many not adjusted for dilution) are not valid measures of individuals’ long-term fluoride exposure, since fluoride has a short half-life and there is substantial variation within days and from day to day,” Levy wrote.

Overall, Levy reiterated much of the same concerns from the National Academies’ reviews, noting the study’s lack of transparency, the reliance on highly biased studies, questionable statistics, and questionable exclusion of newer, higher-quality studies, which have found no link between water fluoridation and children’s IQ. For instance, one exclusion was a 2023 study out of Australia that found “Exposure to fluoridated water during the first 5 [years] of life was not associated with altered measures of child emotional and behavioral development and executive functioning.” A 2022 study out of Spain similarly found no risk of prenatal exposure.

“Taking these many important concerns together, readers are advised to be very cautious in drawing conclusions about possible associations of fluoride exposures with lower IQ,” Levy concluded. “This is especially true for lower water fluoride levels.”

Another controversial study

But, the debate on water fluoridation is unlikely to recede anytime soon. In a second editorial published alongside the NTP study, other researchers praised the analysis, calling for health organizations and regulators to reassess fluoridation.

“The absence of a statistically significant association of water fluoride less than 1.5 mg/L and children’s IQ scores in the dose-response meta-analysis does not exonerate fluoride as a potential risk for lower IQ scores at levels found in fluoridated communities,” the authors argue, noting there are additional sources of fluoride, such as toothpaste and foods.

The EPA estimates that 40 to 70 percent of people’s fluoride exposure comes from water.

Two of the three authors of the second editorial—Christine Till and Bruce Lanphear—were authors of a highly controversial 2019 study out of Canada suggesting that fluoride intake during pregnancy could reduce children’s IQ. The authors even suggested that pregnant people should reduce their fluoride intake. But, the study, also published in JAMA Pediatrics, only found a link between maternal fluoride levels and IQ in male children. There was no association in females.

The study drew heavy backlash, with blistering responses published in JAMA Pediatrics. In one response, UK researchers essentially accused Till and colleagues of a statistical fishing expedition to find a link.

“[T]here was no significant IQ difference between children from fluoridated and nonfluoridated communities and no overall association with maternal urinary fluoride (MUFSG). The authors did not mention this and instead emphasized the significant sex interaction, where the association appeared for boys but not girls. No theoretical rationale for this test was provided; in the absence of a study preregistration, we cannot know whether it was planned a priori. If not, the false-positive probability increases because there are many potential subgroups that might show the result by chance.”

Other researchers criticized the study’s statistics, lack of data transparency, the use of maternal urine sampling, and the test they used to assess the IQ of children ages 3 and 4.

Photo of Beth Mole

Beth is Ars Technica’s Senior Health Reporter. Beth has a Ph.D. in microbiology from the University of North Carolina at Chapel Hill and attended the Science Communication program at the University of California, Santa Cruz. She specializes in covering infectious diseases, public health, and microbes.

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flu-surges-in-louisiana-as-health-department-barred-from-promoting-flu-shots

Flu surges in Louisiana as health department barred from promoting flu shots

The statement seemed to offer an assurance that other vaccines were not subject to the new restrictions. “Changes regarding seasonal vaccines like COVID and influenza do not change the Department’s policy or messaging regarding childhood immunizations,” it read.

This flu season, the health department has reportedly canceled standard vaccination events and clinics. On social media, the department has avoided mentioning flu shots in posts about the flu, instead advising people to wash their hands and cover their coughs.

While Louisiana is seeing an early surge in influenza, the rest of the country is on an upward trend in what appears to be a normal-looking season so far. Nationally, the percentage of doctor visits that were for ILIs is 3.8 percent, with the upswing in ILI activity similar to what was seen in the 2019–2020 flu season at this point in the year. At the peak of flu seasons, the percentage of visits for ILIs usually tops out around 7 percent to 8 percent.

US ILI activity charted by week across several flu seasons Credit: CDC

Two children died last week of flu, bringing the season’s total pediatric deaths to four. In the 2023–2024 season, 206 children died with influenza-associated disease. Most of the deaths occurred in early 2024.

COVID-19 is also ramping up a winter wave. While standard disease burden indicators—hospitalization and deaths—are low, they’re trending positive. Wastewater surveillance, meanwhile, is showing a steep incline, with levels of the virus being detected at “moderate” levels.

Flu surges in Louisiana as health department barred from promoting flu shots Read More »

louisiana-bars-health-dept.-from-promoting-flu,-covid,-mpox-vaccines:-report

Louisiana bars health dept. from promoting flu, COVID, mpox vaccines: Report

Louisiana’s health department has been barred from advertising or promoting vaccines for flu, COVID-19, and mpox, according to reporting by NPR, KFF Health News, and New Orleans Public Radio WWNO.

Their investigative report—based on interviews with multiple health department employees who spoke on the condition of anonymity for fear of retaliation—revealed that employees were told of the startling policy change in meetings in October and November and that the policy would be implemented quietly and not put into writing.

Ars Technica has contacted the health department for comment and will update this post with any new information.

The health department provided a statement to NPR saying that it has been “reevaluating both the state’s public health priorities as well as our messaging around vaccine promotion, especially for COVID-19 and influenza.” The statement described the change as a move “away from one-size-fits-all paternalistic guidance” to a stance in which “immunization for any vaccine, along with practices like mask wearing and social distancing, are an individual’s personal choice.”

According to employees, the new policy cancelled standard fall flu vaccination events this year and affects every other aspect of the health department’s work, as NPR explained:

“Employees could not send out press releases, give interviews, hold vaccine events, give presentations or create social media posts encouraging the public to get the vaccines. They also could not put up signs at the department’s clinics that COVID, flu or mpox vaccines were available on site.”

“We’re really talking about deaths”

The change comes amid a dangerous swell of anti-vaccine sentiment and misinformation in Louisiana and across the country. President-elect Trump has picked Robert F. Kennedy Jr.—a high-profile anti-vaccine advocate and one of the most prolific spreaders of vaccine misinformation—to head the US Department of Health and Human Services.

Louisiana bars health dept. from promoting flu, COVID, mpox vaccines: Report Read More »

louisiana-resident-in-critical-condition-with-h5n1-bird-flu

Louisiana resident in critical condition with H5N1 bird flu

The Louisiana resident infected with H5N1 bird flu is hospitalized in critical condition and suffering from severe respiratory symptoms, the Louisiana health department revealed Wednesday.

The health department had reported the presumptive positive case on Friday and noted the person was hospitalized, as Ars reported. But a spokesperson had, at the time, declined to provide Ars with the patient’s condition or further details, citing patient confidentiality and an ongoing public health investigation.

This morning, the Centers for Disease Control and Prevention announced that it had confirmed the state’s H5N1 testing and determined that the case “marks the first instance of severe illness linked to the virus in the United States.”

In a follow-up, the health department spokesperson Emma Herrock was able to release more information about the case. In addition to being in critical condition with severe respiratory symptoms, the person is reported to be over the age of 65 and has underlying health conditions.

Further, the CDC collected partial genetic data of the H5N1 strain infecting the patient, finding it to be of D1.1. genotype, which has been detected in wild birds and some poultry in the US. Notably, it is the same genotype seen in a Canadian teenager who was also hospitalized in critical condition from the virus last month. The D1.1. genotype is not the same as the one circulating in US dairy cows, which is the B3.13 genotype.

Louisiana resident in critical condition with H5N1 bird flu Read More »

“unprecedented”-decline-in-teen-drug-use-continues,-surprising-experts

“Unprecedented” decline in teen drug use continues, surprising experts

A new era

“Kids who were in eighth grade at the start of the pandemic will be graduating from high school this year, and this unique cohort has ushered in the lowest rates of substance use we’ve seen in decades,” Miech noted.

For alcohol, use in the past 12 months among eighth graders was at 12.9 percent in 2024, similar to 2023 levels, which are all-time lows. For 10th graders, the rate dropped significantly from 30.6 percent in 2023 to 26.1 percent, and for 12th graders, from 45.7 percent to 41.7 percent—both record lows.

For nicotine vaping, rates fell for 10th graders (from 17.5 percent to 15.4 percent) and remained at low levels for eighth and 12th graders. For marijuana, use remained low for eighth and 10th graders and fell significantly for 12th graders (from 29 percent to 25.8 percent). All three grades are at lows not seen since 1990.

For abstainers from alcohol, marijuana, and nicotine in the prior 30 days, the rate among eighth graders hit 90 percent, up from 87 percent in 2017, when it was first measured. The rate was 80 percent among 10th graders, up from 69 percent in 2017, and 67 percent for 12th graders, up from 53 percent in 2017.

“This trend in the reduction of substance use among teenagers is unprecedented,” Nora Volkow, director of NIH’s National Institute on Drug Abuse (NIDA), said. “We must continue to investigate factors that have contributed to this lowered risk of substance use to tailor interventions to support the continuation of this trend.”

“Unprecedented” decline in teen drug use continues, surprising experts Read More »

huge-math-error-corrected-in-black-plastic-study;-authors-say-it-doesn’t-matter

Huge math error corrected in black plastic study; authors say it doesn’t matter

Ars has reached out to the lead author, Megan Liu, but has not received a response. Liu works for the environmental health advocacy group Toxic-Free Future, which led the study.

The study highlighted that flame retardants used in plastic electronics may, in some instances, be recycled into household items.

“Companies continue to use toxic flame retardants in plastic electronics, and that’s resulting in unexpected and unnecessary toxic exposures,” Liu said in a press release from October. “These cancer-causing chemicals shouldn’t be used to begin with, but with recycling, they are entering our environment and our homes in more ways than one. The high levels we found are concerning.”

BDE-209, aka decabromodiphenyl ether or deca-BDE, was a dominant component of TV and computer housings before it was banned by the European Union in 2006 and some US states in 2007. China only began restricting BDE-209 in 2023. The flame retardant is linked to carcinogenicity, endocrine disruption, neurotoxicity, and reproductive harm.

Uncommon contaminant

The presence of such toxic compounds in household items is important for noting the potential hazards in the plastic waste stream. However, in addition to finding levels that were an order of magnitude below safe limits, the study also suggested that the contamination is not very common.

The study examined 203 black plastic household products, including 109 kitchen utensils, 36 toys, 30 hair accessories, and 28 food serviceware products. Of those 203 products, only 20 (10 percent) had any bromine-containing compounds at levels that might indicate contamination from bromine-based flame retardants, like BDE-209. Of the 109 kitchen utensils tested, only nine (8 percent) contained concerning bromine levels.

“[A] minority of black plastic products are contaminated at levels >50 ppm [bromine],” the study states.

But that’s just bromine compounds. Overall, only 14 of the 203 products contained BDE-209 specifically.

The product that contained the highest level of bromine compounds was a disposable sushi tray at 18,600 ppm. Given that heating is a significant contributor to chemical leaching, it’s unclear what exposure risk the sushi tray poses. Of the 28 food serviceware products assessed in the study, the sushi tray was only one of two found to contain bromine compounds. The other was a fast food tray that was at the threshold of contamination with 51 ppm.

Huge math error corrected in black plastic study; authors say it doesn’t matter Read More »

why-do-we-get-headaches-from-drinking-red-wine?

Why do we get headaches from drinking red wine?

Putting enzymes to the test

Testing ALDH was the next step. We set up an inhibition assay in test tubes. In the assay, we measured how fast the enzyme ALDH breaks down acetaldehyde. Then, we added the suspected inhibitors—quercetin, as well as some other phenolics we wanted to test—to see whether they slowed the process.

The chemical structure of quercetin, which may cause red wine headaches.

The chemical structure of quercetin, which may cause red wine headaches. Credit: Johannes Botne (CC BY-SA)

These tests confirmed that quercetin was a good inhibitor. Some other phenolics had varying effects, but quercetin glucuronide was the winner. When your body absorbs quercetin from food or wine, most is converted to glucuronide by the liver in order to quickly eliminate it from the body.

Our enzyme tests suggest that quercetin glucuronide disrupts your body’s metabolism of alcohol. This disruption means extra acetaldehyde circulates, causing inflammation and headaches. This discovery points to what’s known as a secondary, or synergistic, effect.

These secondary effects are much harder to identify because two factors must both be in play for the outcome to arise. In this case, other foods that contain quercetin are not associated with headaches, so you might not initially consider quercetin as the cause of the red wine problem.

The next step could be to give human subjects two red wines that are low and high in quercetin and ask whether either wine causes a headache. If the high-quercetin wine induces more headaches, we’d know we’re on the right track.

So, if quercetin causes headaches, are there red wines without it? Unfortunately, the data available on specific wines is far too limited to provide any helpful advice. However, grapes exposed to the Sun do produce more quercetin, and many inexpensive red wines are made from grapes that see less sunlight.

If you’re willing to take a chance, look for an inexpensive, lighter red wine.

Andrew Waterhouse is professor of enology, University of California, Davis, and Apramita Devi is a postdoctoral researcher in food science and technology, University of California, Davis.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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bird-flu-jumps-from-birds-to-human-in-louisiana;-patient-hospitalized

Bird flu jumps from birds to human in Louisiana; patient hospitalized

A person in Louisiana is hospitalized with H5N1 bird flu after having contact with sick and dying birds suspected of carrying the virus, state health officials announced Friday.

It is the first human H5N1 case detected in Louisiana. For now, the case is considered a “presumptive” positive until testing is confirmed by the Centers for Disease Control and Prevention. Health officials say that the risk to the public is low but caution people to stay away from any sick or dead birds.

Although the person has been hospitalized, their condition was not immediately reported. It’s also unclear what kind of birds the person had contact with—wild, backyard, or commercial birds. Ars has reached out to Louisiana’s health department and will update this piece with any additional information.

The case is just the latest amid H5N1’s global and domestic rampage. The virus has been ravaging birds of all sorts in the US since early 2022 and spilling over to a surprisingly wide range of mammals. In March this year, officials detected an unprecedented leap to dairy cows, which has since caused a nationwide outbreak. The virus is currently sweeping through California, the country’s largest dairy producer.

To date, at least 845 herds across 16 states have contracted the virus since March, including 630 in California, which detected its first dairy infections in late August.

Human cases

At least 60 people in the US have been infected amid the viral spread this year. But the new case in Louisiana stands out. To date, nearly all of the human cases have been among poultry and dairy workers—unlike the new case in Louisiana— and almost all have been mild—also unlike the new case. Most of the cases have involved conjunctivitis—pink eye—and/or mild respiratory and flu-like symptoms.

There was a case in a patient in Missouri who was hospitalized. However, that person had underlying health conditions, and it’s unclear if H5N1 was the cause of their hospitalization or merely an incidental finding. It remains unknown how the person contracted the virus. An extensive investigation found no animal or other exposure that could explain the infection.

Bird flu jumps from birds to human in Louisiana; patient hospitalized Read More »

americans-spend-more-years-being-unhealthy-than-people-in-any-other-country

Americans spend more years being unhealthy than people in any other country

For the new study, researchers at the Mayo Clinic analyzed health statistics collected by the World Health Organization. The resource included data from 183 countries, allowing the researchers to compare countries’ life expectancy and healthspans, which are calculated by years of life weighted by health status.

Longer, but not better

Overall, the researchers saw lifespan-healthspan gaps grow around the world, with the average gap rising from 8.5 years in 2000 to 9.6 years in 2019. Global life expectancy rose 6.5 years, to about 73 years, while healthspans only rose 5.4 years in that time, to around 63 years.

But the US was a notable outlier, with its gap growing from 10.9 years to 12.4 years, a 29 percent higher gap than the global mean.

The gap was most notable for women—a trend seen around the world. Between 2000 and 2019, US women saw their life expectancy rise 1.5 years, from 79.2 to 80.7 years, but they saw no change in their healthspans. Women’s lifespan-healthspan gap rose from 12.2 years to 13.7 years. For US men, life expectancy rose 2.2 years, from 74.1 to 76.3 years, and their healthspans also increased 0.6 years. Their lifespan-healthspan gap in 2019 was 11.1 years, 2.6 years shorter than women’s.

The conditions most responsible for US disease burden included mental and substance use disorders, plus musculoskeletal diseases. For women, the biggest contributors were musculoskeletal, genitourinary, and neurological diseases.

While the US presented the most extreme example, the researchers note that the global trends seem to present a “disease paradox whereby reduced acute mortality exposes survivors to an increased burden of chronic disease.”

Americans spend more years being unhealthy than people in any other country Read More »

avian-flu-cases-are-on-the-upswing-at-big-dairy-farms

Avian flu cases are on the upswing at big dairy farms


Rise in cases amplifies concerns about consolidation in agriculture.

Holstein dairy cows in a freestall barn. Credit: Getty |

A handful of dairy farms sprawl across the valley floor, ringed by the spikey, copper-colored San Jacinto mountains. This is the very edge of California’s dairy country—and so far, the cows here are safe.

But everyone worries that the potentially lethal bird flu is on the way. “I hope not,” says Clemente Jimenez, as he fixes a hose at Pastime Lakes, a 1,500-head dairy farm. “It’s a lot of trouble.”

Further north and west, in the San Joaquin Valley—the heart of the state’s dairy industry—the H5N1 virus, commonly known as bird flu, has rippled through the massive herds that provide most of the country’s milk. Farmworkers have piled carcasses into black and white heaps. This week the state reported 19 new confirmed cases in cows and more than 240,000 in chickens. Another 50,000 cases were confirmed at a chicken breeding facility in Oklahoma.

Most worrying, though, is the spillover from livestock to humans. So far, 58 people in the United States have tested positive for bird flu. Fifty-six of them worked either on dairy or poultry farms where millions of birds had to be culled.

The Centers for Disease Control and Prevention confirmed that four of the cases in humans had no known connection to livestock, raising fears that the virus eventually could jump from one human to another, though that hasn’t happened yet. On Thursday, a study published in Science by researchers at The Scripps Research Institute said it would take only a single mutation in the H5N1 virus for it to attach itself to human receptor cells.

Large livestock facilities in states across the country, and especially in California, have become the epicenters of these cases, and some researchers say that’s no surprise: Putting thousands, even hundreds of thousands, of animals together in confined, cramped barns or corrals creates a petri dish for viruses to spread, especially between genetically similar and often stressed animals.

More drought and higher temperatures, fueled by climate change, supercharge those conditions.

“Animal production acts like a connectivity for the virus,” said Paula Ribeiro Prist, a conservation scientist with the EcoHealth Alliance, a not-for-profit group that focuses on research into pandemics. “If you have a lot of cattle being produced in more places, you have a higher chance of the virus spreading. When you have heat stress, they’re more vulnerable.”

So far, this bird flu outbreak has affected more than 112 million chickens, turkeys, and other poultry across the US since it was first detected at a turkey-producing facility in Indiana in February 2022. In March of this year, officials confirmed a case of the virus in a Texas dairy cow—the first evidence that the virus had jumped from one livestock species to another. Since then, 720 cows have been affected, most of them in California, where there have been nearly 500 recorded cases.

In the United States, a trend of consolidation in agriculture, particularly dairies, has seen more animals housed together on ever-larger farms as the number of small farms has rapidly shrunk. In 1987, half of the country’s dairy cows were in herds of 80 or more, and half in herds of 80 or fewer. Twenty years later, half the country’s cows were raised in herds of 1,300 or more. Today, 5,000-head dairies are common, especially in the arid West.

California had just over 21,000 dairy farms in 1950, producing 5.6 billion pounds of milk. Today, it has 1,100 producing around 41 billion pounds. Total US milk production has soared from about 116 billion pounds in 1950 to about 226 billion today.

“The pace of consolidation in dairy far exceeds the pace of consolidation seen in most of US agriculture,” a recent USDA report said.

Initially, researchers thought the virus was spreading through cows’ respiration, but recent research suggests it’s being transmitted through milking equipment and milk itself.

“It’s been the same strain in dairy cows… We don’t necessarily have multiple events of spillover,” said Meghan Davis, an associate professor of environmental health and engineering at Johns Hopkins Bloomberg School of Public Health. “Now it’s transmission from one cow to the next, often through milking equipment.”

It’s still unclear what caused that initial jump from wild birds, which are the natural reservoirs of the virus, to commercial poultry flocks and then to cows, but some research suggests that changing migration patterns caused by warmer weather are creating conditions conducive to the spreading of viruses. Some wild birds are migrating earlier than usual, hatching juvenile birds in new or different habitats.

“This is leading to a higher number of young that are naive to the virus,” Prist explained. “This makes the young birds more infectious—they have a higher chance of transmitting the virus because they don’t have antibodies protecting them.

“They’re going to different areas and they’re staying longer,” Prist added, “so they have higher contact with other animals, to the other native populations, that they have never had contact [with] before.”

That, researchers believe, could have initiated the spillover from wild birds to poultry, where it has become especially virulent. In wild birds, the virus tends to be a low pathogenic strain that occurs naturally, causing only minor symptoms in some birds.

“But when we introduce the virus to poultry operations where birds live in unsanitary and highly confined conditions, the virus is … able to spread through them like wildfire,” said Ben Rankin, a legal expert with the Center for Biological Diversity, an advocacy group. “There are so many more opportunities for the virus to mutate, to adapt to new kinds of hosts, and eventually, the virus spills back into the wild and this creates this cycle, or this loop, of intensification and increasing pathogenicity.”

Rankin pointed to an analysis that looked at 39 different viral outbreaks in birds from 1959 to 2015, where a low pathogenic avian influenza became a highly pathogenic one. Out of those, 37 were associated with commercial poultry operations. “So it’s a very clear relationship between the increasing pathogenicity of this virus and its relationship with industrial animal raising,” Rankin said.

Some researchers worry that large farms with multiple species are providing the optimal conditions for more species-to-species transfer. In North Carolina, the second-largest hog-producing state after Iowa, some farmers have started raising both chickens and hogs under contracts that require huge numbers of animals.

“So you’ve got co-location at a pretty substantial scale of herd size, on a single property,” said Chris Heaney, an associate professor of environmental health, engineering, epidemiology, and international health at the Bloomberg School of Public Health. “Another concern is seeing it jump into swine. That host, in particular, is uniquely well suited for those influenza viruses to re-assort and acquire properties that are very beneficial for taking up residence in humans.”

In late October, the USDA reported the first case of bird flu in a pig that lived on a small poultry and hog farm in Oregon.

Farmworker advocates say the number of cases in humans is likely underreported, largely because the immigrant and non-English speaking workforce on farms could be reluctant to seek help or may not be informed about taking precautions.

“What we’re dealing with is the lack of information from the top to the workers,” said Ana Schultz, a director with Project Protect Food Systems Workers.

In northern Colorado, home to dozens of large dairies, Schultz started to ask dairy workers in May if they were getting protective gear and whether anyone was falling ill. Many workers told her they were feeling flu-ish but didn’t go to the doctor for fear of losing a day of work or getting fired.

“I feel like there’s a lot more avian flu incidents, but no one knows about it because they don’t go to the doctor and they don’t get tested,” Schultz said. “In all the months that we’ve been doing outreach and taking protective gear and flyers, we haven’t had one single person tell us they’ve been to the doctor.”

This story originally appeared on Inside Climate News.

Georgina Gustin covers agriculture for Inside Climate News and has reported on the intersections of farming, food systems, and the environment for much of her journalism career. Her work has won numerous awards, including the John B. Oakes Award for Distinguished Environmental Journalism, and she was twice named the Glenn Cunningham Agricultural Journalist of the Year, once with ICN colleagues. She has worked as a reporter for The Day in New London, Conn., the St. Louis Post-Dispatch and CQ Roll Call, and her stories have appeared in The New York Times, Washington Post, and National Geographic’s The Plate, among others. She is a graduate of the Columbia University Graduate School of Journalism and the University of Colorado at Boulder.

Photo of Inside Climate News

Avian flu cases are on the upswing at big dairy farms Read More »

us-to-start-nationwide-testing-for-h5n1-flu-virus-in-milk-supply

US to start nationwide testing for H5N1 flu virus in milk supply

So, the ultimate goal of the USDA is to eliminate cattle as a reservoir. When the Agency announced it was planning for this program, it noted that there were two candidate vaccines in trials. Until those are validated, it plans to use the standard playbook for handling emerging infections: contact tracing and isolation. And it has the ability to compel cattle and their owners to be more cooperative than the human population turned out to be.

The five-step plan

The USDA refers to isolation and contact tracing as Stage 3 of a five-stage plan for controlling H5N1 in cattle, with the two earlier stages being the mandatory sampling and testing, meant to be handled on a state-by-state basis. Following the successful containment of the virus in a state, the USDA will move on to batch sampling to ensure each state remains virus-free. This is essential, given that we don’t have a clear picture of how many times the virus has jumped from its normal reservoir in birds into the cattle population.

That makes it possible that reaching Stage 5, which the USDA terms “Demonstrating Freedom from H5 in US Dairy Cattle,” will turn out to be impossible. Dairy cattle are likely to have daily contact with birds, and it may be that the virus will be regularly re-introduced into the population, leaving containment as the only option until the vaccines are ready.

Testing will initially focus primarily on states where cattle-to-human transmission is known to have occurred or the virus is known to be present: California, Colorado, Michigan, Mississippi, Oregon, and Pennsylvania. If you wish to track the progress of the USDA’s efforts, it will be posting weekly updates.

US to start nationwide testing for H5N1 flu virus in milk supply Read More »

splash-pads-really-are-fountains-of-fecal-material;-cdc-reports-10k-illnesses

Splash pads really are fountains of fecal material; CDC reports 10K illnesses

Once infectious material gets into the water, disinfection systems that aren’t working properly or are inadequate can allow pathogens to gush from every nozzle. Splash pads aren’t unique in having to handle sick children in poopy swim diapers—but they are unique in how they are regulated. That is, in some places, they’re not regulated at all. Splash pads are designed to not have standing water, therefore reducing the risk of young children drowning. But, because they lack standing water, they are sometimes deemed exempt from local health regulations. Before 2000, only 13 states regulated splash pads. Though many states have since added regulations, some did so only after splash pad-linked outbreaks were reported.

Downpour of disease

The primary method for keeping recreational water free of infectious viruses and bacteria is chlorinating it. However, maintaining germ-killing chlorine concentration is especially difficult for splash pads because the jets and sprays aerosolize chlorine, lowering the concentration.

Still, in most splash-pad linked outbreaks, standard chlorine concentrations aren’t enough anyway. The most common pathogen to cause an outbreak at splash pads is the parasite Cryptosporidium, aka Crypto. The parasite’s hardy spores, called oocysts, are extremely tolerant of chlorine, surviving in water with the standard chlorine concentration (1 ppm free chlorine) for over seven days. (Other germs die in minutes.) In splash pads that might not even have that standard chlorine concentration, Crypto flourishes and can cause massive outbreaks.

In 2023, the CDC recommended new health codes that call for “secondary disinfection” methods to keep Crypto at bay, including disinfection systems using ozone or ultraviolet light. Another possible solution is to have “single-pass” splash pads that don’t recirculate water.

In all, to keep splash pads from being geysers of gastrointestinal parasites and pathogens, various changes have to happen, the CDC experts say.

“Prevention of waterborne disease outbreaks at splash pads requires changes in user behavior; recreational venue code updates; and improved venue design, construction, operation, and management of facilities,” they conclude. But it should all start with keeping kids from sitting on jets and drinking the water.

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