health

all-17-fired-vaccine-advisors-unite-to-blast-rfk-jr.’s-“destabilizing-decisions”

All 17 fired vaccine advisors unite to blast RFK Jr.’s “destabilizing decisions”

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The members highlighted their medical and scientific expertise, lengthy vetting, transparent processes, and evidence-based approach to helping set federal immunization programs, which affect insurance coverage. They also lamented the institutional knowledge lost by the removal of the entire committee and its executive secretary, as well as cuts to the CDC broadly. Together they “have left the US vaccine program critically weakened,” the experts write.

“In this age of government efficiency, the US public needs to know that the routine vaccination of approximately 117 million children from 1994–2023 likely prevented around 508 million lifetime cases of illness, 32 million hospitalizations, and 1,129,000 deaths, at a net savings of $540 billion in direct costs and $2.7 trillion in societal costs,” they write.

They also took direct aim at Kennedy, who unilaterally changed the COVID-19 vaccination policy, announcing the changes on social media. This “bypassed the standard, transparent, and evidence-based review process,” they write. “Such actions reflect a troubling disregard for the scientific integrity that has historically guided US immunization strategy.”

Since Kennedy has taken over the US health department, many other vaccine experts have been pushed out or left voluntarily. Peter Marks, the former top vaccine regulator at the Food and Drug Administration, was reportedly given the choice to resign or be fired. In his resignation letter, he wrote: “it has become clear that truth and transparency are not desired by the Secretary [Kennedy], but rather he wishes subservient confirmation of his misinformation and lies.”

All 17 fired vaccine advisors unite to blast RFK Jr.’s “destabilizing decisions” Read More »

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New COVID variant swiftly gains ground in US; concern looms for summer wave

CDC, COVID-19, ECDC, Europe, health, NB.1.8.1, omicron, SARS-CoV-2, vaccines, variant, WHO / /

While COVID-19 transmission remains low in the US, health experts are anxious about the potential for a big summer wave as two factors seem set for a collision course: a lull in infection activity that suggests protective responses have likely waned in the population, and a new SARS-CoV-2 variant with an infectious advantage over other variants.

The new variant is dubbed NB.1.8.1. Like all the other currently circulating variants, it’s a descendant of omicron. Specifically, NB.1.8.1 is derived from the recombinant variant XDV.1.5.1. Compared to the reigning omicron variants JN.1 and LP.8.1, the new variant has a few mutations that could help it bind to human cells more easily and evade some protective immune responses.

On May 23, the World Health Organization designated NB.1.8.1 a “variant under monitoring,” meaning that early signals indicate it has an advantage over other variants, but its impact on populations is not yet clear. In recent weeks, parts of Asia, including China, Hong Kong, Singapore, and Taiwan, have experienced increases in infections and hospitalizations linked to NB.1.8.1’s spread. Fortunately, the variant does not appear to cause more severe disease, and current vaccines are expected to remain effective against it.

Still, it appears to be swiftly gaining ground in the US, fueling worries that it could cause a surge here as well. In the latest tracking data from the Centers for Disease Control and Prevention, NB.1.8.1 is estimated to account for 37 percent of cases in the US. That’s up from 15 percent two weeks ago. NB.1.8.1 is now poised to overtake LP.8.1, which is estimated to make up 38 percent of cases.

It’s important to note that those estimates are based on limited data, so the CDC cautions that there are large possible ranges for the variants’ actual proportions. For NB.1.81, the potential percentage of cases ranges from 13 percent to 68 percent, while LP.8.1’s is 23 percent to 57 percent.

New COVID variant swiftly gains ground in US; concern looms for summer wave Read More »

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After a series of tumors, woman’s odd-looking tongue explains everything

cowden syndrome, health, PTEN / /

Breast cancer. Colon cancer. An enlarged thyroid gland. A family history of tumors and cancers as well. It wasn’t until the woman developed an annoying case of dry mouth that doctors put it all together. By then, she was in her 60s.

According to a new case study in JAMA Dermatology, the woman presented to a dermatology clinic in Spain after three months of oral unpleasantness. They noted the cancers in her medical history. When she opened wide, doctors immediately saw the problem: Her tongue was covered in little wart-like bumps that resembled a slippery, flesh-colored cobblestone path. (Image here.)

Such a cobblestone tongue is a telltale sign of a rare genetic condition called Cowden syndrome. It’s caused by inherited mutations that break a protein, called PTEN, leading to tumors and cancers.

PTEN, which stands for phosphatase and tensin homolog, generally helps keep cells from growing out of control. Specifically, PTEN deactivates a signaling lipid called PIP3 (phosphatidylinositol 3,4,5-trisphosphate), and that deactivation blocks a signaling pathway (the PI3K/AKT/mTOR pathway) involved in regulating cell growth, survival, and migration. When PTEN is broken, PIP3 activity ramps up, and tumors can grow unchecked.

Not-so-rare mutation

In Cowden syndrome, PTEN mutations lead to noncancerous tumors or masses called hamartomas, which can occur in any organ. But, people with the syndrome are also at high risk of developing a slew of cancerous growths—most commonly cancers of the breast, thyroid, and uterus—over their lifetime. That’s why people diagnosed with the condition are advised to undergo intensive cancer screenings, including annual ultrasounds of the thyroid starting at age 7 and annual mammograms and MRIs (magnetic resonance imaging) starting at age 30 at the latest.

After a series of tumors, woman’s odd-looking tongue explains everything Read More »

rfk-jr.-announces-8-appointees-to-cdc-vaccine-panel—they’re-not-good

RFK Jr. announces 8 appointees to CDC vaccine panel—they’re not good

CDC, health, Robert F Kenned Jr., robert malone, vaccines / /

Anti-vaccine advocate and current Health Secretary Robert F. Kennedy Jr. took to social media Wednesday to announce the names of eight people he is appointing to a critical federal vaccine advisory committee—which is currently empty after Kennedy abruptly fired all 17 previous members Monday.

In the past, the vetting process for appointing new members to the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices (ACIP) could take years. But Kennedy has taken just two days.

The panel, typically stocked with vaccine, infectious disease, and public health experts, carefully and publicly reviews, analyzes, and debates vaccine data and offers recommendations to the CDC via votes. The CDC typically adopts the recommendations, which set clinical practices nationwide and determine insurance coverage for vaccinations.

Yesterday, Kennedy pledged that none of the new ACIP members would be “ideological anti-vaxxers.” However, the list of today’s appointees includes Robert Malone, who falsely claims to have invented mRNA vaccines and has spent the past several years spreading misinformation and conspiracy theories about them.

Speaking at an anti-vaccine rally in 2022, Malone spread dangerous falsehoods about mRNA COVID-19 vaccines: “These genetic vaccines can damage your children. They may damage their brains, their heart, their immune system and their ability to have children in the future. Many of these damages cannot be repaired.”

Troubling list

Malone aligned with the anti-vaccine crowd during the pandemic and has become a mainstay in conspiratorial circles and an ally to Kennedy. He has claimed that vaccines cause a “form of AIDS,” amid other nonsense. He has also meddled with responses to the measles outbreak that erupted in West Texas in January. In April, Malone was the first to publicize news that a second child had died from the highly infectious and serious infection, but he did so to falsely claim that measles wasn’t the cause and spread other dangerous misinformation.

RFK Jr. announces 8 appointees to CDC vaccine panel—they’re not good Read More »

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False claims that ivermectin treats cancer, COVID lead states to pass OTC laws

cancer, fda, health, ivermectin, Social Media / /

Doctors told the Times that they have already seen some cases where patients with treatable, early-stage cancers have delayed effective treatments to try ivermectin, only to see no effect and return to their doctor’s office with cancers that have advanced.

Risky business

Nevertheless, the malignant misinformation on social media has made its way into state legislatures. According to an investigation by NBC News published Monday, 16 states have proposed or passed legislation that would make ivermectin available over the counter. The intention is to make it much easier for people to get ivermectin and use it for any ailment they believe it can cure.

Idaho, Arkansas, and Tennessee have passed laws to make ivermectin available over the counter. On Monday, Louisiana’s state legislature passed a bill to do the same, and it now awaits signing by the governor. The other states that have considered or are considering such bills include: Alabama, Georgia, Kentucky, Maine, Minnesota, Mississippi, New Hampshire, North Carolina, North Dakota, Pennsylvania, South Carolina, and West Virginia.

State laws don’t mean the dewormer would be readily available, however; ivermectin is still regulated by the Food and Drug Administration, and it has not been approved for over-the-counter use yet. NBC News called 15 independent pharmacies in the three states that have laws on the books allowing ivermectin to be sold over the counter (Idaho, Arkansas, and Tennessee) and couldn’t find a single pharmacist who would sell it without a prescription. Pharmacists pointed to the federal regulations.

Likewise, CVS Health said its pharmacies are not currently selling ivermectin over the counter in any state. Walgreens declined to comment.

Some states, such as Alabama, have considered legislation that would protect pharmacists from any possible disciplinary action for dispensing ivermectin without a prescription. However, one pharmacist in Idaho, who spoke with NBC News, said that such protection would still not be enough. As a prescription-only drug, ivermectin is not packaged for retail sale. If it were, it would include over-the-counter directions and safety statements written specifically for consumers.

“If you dispense something that doesn’t have directions or safety precautions on it, who’s ultimately liable if that causes harm?” the pharmacist said. “I don’t know that I would want to assume that risk.”

It’s a risk people on social media don’t seem to be concerned with.

False claims that ivermectin treats cancer, COVID lead states to pass OTC laws Read More »

anti-vaccine-advocate-rfk-jr.-fires-entire-cdc-panel-of-vaccine-advisors

Anti-vaccine advocate RFK Jr. fires entire CDC panel of vaccine advisors

ACIP, CDC, health, Robert F Kenned Jr., vaccines / /

“Most likely aim to serve the public interest as they understand it,” he wrote. “The problem is their immersion in a system of industry-aligned incentives and paradigms that enforce a narrow pro-industry orthodoxy.”

Kennedy, who is currently trying to shift the national attention to his idea of clean living and higher-quality foods, has a long history of advocating against vaccines, spreading misinformation and disinformation about the lifesaving shots. However, a clearer explanation of Kennedy’s war on vaccines can be found in his rejection of germ theory. In his 2021 book that vilifies infectious disease expert Anthony Fauci, he bemoaned germ theory as “the pharmaceutical paradigm that emphasized targeting particular germs with specific drugs rather than fortifying the immune system through healthy living, clean water, and good nutrition.”

As such, he rails against the “$1 trillion pharmaceutical industry pushing patented pills, powders, pricks, potions, and poisons.”

In Kennedy’s op-ed, he indicates that new ACIP members will be appointed who “won’t directly work for the vaccine industry. … will exercise independent judgment, refuse to serve as a rubber stamp, and foster a culture of critical inquiry.”

It’s unclear how the new members will be vetted and appointed and when the new committee will be assembled.

In a statement, the president of the American Medical Association, Bruce Scott, rebuked Kennedy’s firings, saying that ACIP “has been a trusted national source of science- and data-driven advice and guidance on the use of vaccines to prevent and control disease.” Today’s removal “undermines that trust and upends a transparent process that has saved countless lives,” he continued. “With an ongoing measles outbreak and routine child vaccination rates declining, this move will further fuel the spread of vaccine-preventable illnesses.”

This post has been updated to include a statement from the AMA. This story is breaking and may be updated further.

Anti-vaccine advocate RFK Jr. fires entire CDC panel of vaccine advisors Read More »

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NIH scientists publish “Bethesda Declaration” rebuking Trump admin

Bethesda Declaration, Great Barrington Declaration, health, NIH, Policy / /

Backlash to the idea was quick, with the World Health Organization Director-General Tedros Adhanom Ghebreyesus immediately calling it “unethical.”

“Allowing a dangerous virus that we don’t fully understand to run free is simply unethical. It’s not an option,” Tedros said in a news briefing at the time.

“A risk”

In the letter on Monday, NIH researchers speak directly to Bhattacharya, writing, “We hope you will welcome this dissent, which we modeled after your Great Barrington Declaration.” They titled the letter “The Bethesda Declaration,” named after the NIH’s location in Maryland.

“Standing up in this way is a risk, but I am much more worried about the risks of not speaking up,” Jenna Norton, a program officer at the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases, said in a statement. “If we don’t speak up, we allow continued harm to research participants and public health in America and across the globe. If we don’t speak up, we allow our government to curtail free speech, a fundamental American value.”

The organization leading the NIH dissent, Stand Up For Science, published a second letter on Monday in support of the Bethesda Declaration. The support letter is signed by over a dozen Nobel laureates and former NIH directors Jeremy Berg and Joshua Gordon.

Tomorrow, Bhattacharya will testify before the Senate Appropriations Committee on the Trump administration’s 2026 budget proposal for the NIH, which proposes a cut of about 40 percent to the agency’s $48 billion budget.

NIH scientists publish “Bethesda Declaration” rebuking Trump admin Read More »

anti-vaccine-quack-hired-by-rfk-jr.-has-started-work-at-the-health-department

Anti-vaccine quack hired by RFK Jr. has started work at the health department

anti-vaccine, autism, health, robert f kennedy jr, thimerosal, vaccine / /

Outside researchers can request access to VSD data by submitting study proposals to the CDC. The Geiers have, in the past, gained access. But, they lost that access at least twice, the Journal reported. In 2004, the CDC kicked the Geiers out after officials determined that they had misrepresented their plans for the data when they initially submitted their proposal to the CDC. They were barred again in 2006.

Now an HHS employee, Geier is seeking access to the data once again. The Journal reports that Kennedy has assigned researchers at the National Institutes of Health to assist Geier and that those NIH employees have sent a request to the CDC to hand over all of VSD’s data. This request reportedly caused alarm at the CDC and the project’s health care sites around the country, which are concerned about protecting the security of private patient data.

It’s unclear whether Geier has regained access to the data. But people familiar with the matter told the Journal that Geier aims to reanalyze the CDC’s data on thimerosal to try to prove a link to autism. The sources also said that Geier is interested in proving that the CDC is corrupt.

In the May hearing, Kennedy, who also supports the debunked claim that vaccines cause autism, defended Geier. Kennedy said that “there has been a lot of monkey business with the VSD” and that Geier is “the only living independent scientist” who has seen the data and can determine if it has been altered. (Hassan interjected that Geier is not a scientist.) Kennedy also falsely claimed that a court overturned the medical board’s finding that he had practiced medicine without a license and awarded Geier $5 million.

That did not happen. But Kennedy may have been referring to the fact that Mark Geier filed a lawsuit against the medical board over a 2012 cease-and-desist order that alleged he improperly prescribed medication for himself, his wife, and his son while his medical license was suspended. Mark Geier sued the board, saying the order was malicious because it contained personal information, including the medications Geier had prescribed. A Circuit Court sided with the Geiers, awarding them nearly $5 million in total. But the win and the award were overturned on appeal in 2019.

Anti-vaccine quack hired by RFK Jr. has started work at the health department Read More »

fda-rushed-out-agency-wide-ai-tool—it’s-not-going-well

FDA rushed out agency-wide AI tool—it’s not going well

AI, fda, health / /

FDA staffers who spoke with Stat news, meanwhile, called the tool “rushed” and said its capabilities were overinflated by officials, including Makary and those at the Department of Government Efficiency (DOGE), which was headed by controversial billionaire Elon Musk. In its current form, it should only be used for administrative tasks, not scientific ones, the staffers said.

“Makary and DOGE think AI can replace staff and cut review times, but it decidedly cannot,” one employee said. The staffer also said that the FDA has failed to set up guardrails for the tool’s use. “I’m not sure in their rush to get it out that anyone is thinking through policy and use,” the FDA employee said.

According to Stat, Elsa is based on Anthropic’s Claude LLM and is being developed by consulting firm Deloitte. Since 2020, Deloitte has been paid $13.8 million to develop the original database of FDA documents that Elsa’s training data is derived from. In April, the firm was awarded a $14.7 million contract to scale the tech across the agency. The FDA said that Elsa was built within a high-security GovCloud environment and offers a “secure platform for FDA employees to access internal documents while ensuring all information remains within the agency.”

Previously, each center within the FDA was working on its own AI pilot. However, after cost-cutting in May, the AI pilot originally developed by the FDA’s Center for Drug Evaluation and Research, called CDER-GPT, was selected to be scaled up to an FDA-wide version and rebranded as Elsa.

FDA staffers in the Center for Devices and Radiological Health told NBC News that their AI pilot, CDRH-GPT, is buggy, isn’t connected to the Internet or the FDA’s internal system, and has problems uploading documents and allowing users to submit questions.

FDA rushed out agency-wide AI tool—it’s not going well Read More »

top-cdc-covid-vaccine-expert-resigns-after-rfk-jr.-unilaterally-restricts-access

Top CDC COVID vaccine expert resigns after RFK Jr. unilaterally restricts access

anti-vaccine, CDC, COVID-19, health, robert f kennedy jr, vaccines / /

A top expert at the Centers for Disease Control and Prevention who was overseeing the process to update COVID-19 vaccine recommendations resigned on Tuesday.

The resignation, first reported by The Associated Press and confirmed by CBS News, comes just a week after health secretary and anti-vaccine advocate Robert F. Kennedy Jr. unilaterally revoked and altered some of the CDC’s recommendations for COVID-19 vaccines, restricting access to children and pregnant people. The resignation also comes three weeks before CDC’s experts and advisors are scheduled to meet to publicly evaluate data and discuss the recommendations for this season—a long-established process that was disrupted by Kennedy’s announcement.

The departing CDC official, Lakshmi Panagiotakopoulos, a pediatric infectious disease expert, was a co-leader of a working group on COVID-19 vaccines who advised experts on the CDC’s Advisory Committee on Immunization Practices (ACIP). She informed her ACIP colleagues of her resignation in an email on Tuesday.

“My career in public health and vaccinology started with a deep-seated desire to help the most vulnerable members of our population, and that is not something I am able to continue doing in this role,” Panagiotakopoulos wrote.

Unilateral changes

Previously, the CDC and ACIP recommended COVID-19 vaccines for everyone ages 6 months and up. Experts have emphasized that pregnant people in particular should get vaccinated, as pregnancy suppresses the immune system and puts pregnant people at high risk of severe COVID-19 and death. The American College of Obstetricians and Gynecologists states that “COVID-19 infection during pregnancy can be catastrophic.” Further, dozens of studies have found that the vaccines are safe and effective at protecting the pregnant person, the pregnancy, and newborns.

Top CDC COVID vaccine expert resigns after RFK Jr. unilaterally restricts access Read More »

colon-cancer-recurrence-and-deaths-cut-28%-by-simple-exercise,-trial-finds

Colon cancer recurrence and deaths cut 28% by simple exercise, trial finds

aerobic, clinical trial, colon cancer, Exercise, health, MET, NEJM / /

“Quite impressive”

The exercise group, which had supervised exercise for the first six months of the three-year intervention, reported more exercise over the study. At the end, the exercise group was averaging over 20 MET hours per week, while the education group’s average was around 15 MET hours per week. The exercise group also scored better at cardiorespiratory fitness and physical functioning.

Still, with the health education, the control group also saw a boost to their exercise during the trial, with their average starting around 10 MET hours per week. These findings “raise the possibility of an even more powerful effect of exercise on cancer outcomes as compared with a completely sedentary control group,” the researchers note.

For now, it’s not entirely clear how exercise keeps cancers at bay, but it squares with numerous other observational studies that have linked exercise to better outcomes in cancer patients. Researchers have several hypotheses, including that exercise might cause “increased fluid shear stress, enhanced immune surveillance, reduced inflammation, improved insulin sensitivity, and altered microenvironment of major sites of metastases,” the authors note.

In the study, exercise seemed to keep local and distant colon cancer from recurring, as well as prevent new cancers, including breast, prostate, and colorectal cancers.

Outside experts hailed the study’s findings. “This indicates that exercise has a similarly strong effect as previously shown for chemotherapy, which is really quite impressive,” Marco Gerlinger, a gastrointestinal cancer expert at Queen Mary University of London, said in a statement. “One of the commonest questions from patients is what they can do to reduce the risk that their cancer comes back. Oncologists can now make a very clear evidence-based recommendation.”

“Having worked in bowel cancer research for 30 years, this is an exciting breakthrough in the step-wise improvement in cure rates,” David Sebag-Montefiore, a clinical oncologist at the University of Leeds, said. “The great appeal of a structured moderate intensity exercise is that it offers the benefits without the downside of the well-known side effects of our other treatments.”

Colon cancer recurrence and deaths cut 28% by simple exercise, trial finds Read More »

cdc-updates-covid-vaccine-recommendations,-but-not-how-rfk-jr.-wanted

CDC updates COVID vaccine recommendations, but not how RFK Jr. wanted

CDC, centers for disease control and prevention, health, rfk jr, vaccines / /

In practice, it is unclear how this change will affect access to the vaccines. Health insurers are required to cover vaccines on the CDC schedules. But, it’s yet to be seen if children will only be able to get vaccinated at their doctor’s office (rather than a pharmacy or vaccine clinic) or if additional consent forms would be required, etc. Uncertainty about the changes and requirements alone may lead to fewer children getting vaccinated.

In the adult immunization schedule, when viewed “by medical condition or other indication” (table 2), the COVID-19 vaccination recommendation for pregnancy is now shaded gray, meaning “no guidance/not applicable.” Hovering a cursor over the box brings up the recommendation to “Delay vaccination until after pregnancy if vaccine is indicated.” Previously, COVID-19 vaccines were recommended during pregnancy. The change makes it less likely that health insurers will cover the cost of vaccination during pregnancy.

The change is at odds with Trump’s Food and Drug Administration, which just last week confirmed that pregnancy puts people at increased risk of severe COVID-19 and, therefore, vaccination is recommended. Medical experts have decried the loss of the recommendation, which is also at odds with clear data showing the risks of COVID-19 during pregnancy and the benefits of vaccination.

The President of the American College of Obstetricians and Gynecologists (ACOG) put out a statement shortly after the Tuesday video, saying that the organization was “extremely disappointed” with Kennedy’s announcement.

“It is very clear that COVID-19 infection during pregnancy can be catastrophic and lead to major disability, and it can cause devastating consequences for families,” ACOG President Steven Fleischman said.

CDC updates COVID vaccine recommendations, but not how RFK Jr. wanted Read More »