Science – Page 35

Research monkeys still having a ball days after busting out of lab, policy say

escape, health, monkeys, research, Science / DJ Henderson / November 8, 2024

If you need any inspiration for cutting loose and relaxing this weekend, look no further than a free-wheeling troop of monkeys that broke out of their South Carolina research facility Wednesday and, as of noon Friday, were still “playfully exploring” with their newfound freedom.

In an update Friday, the police department of Yemassee, SC said that the 43 young, female rhesus macaque monkeys are still staying around the perimeter of the Alpha Genesis Primate Research Facility. “The primates are exhibiting calm and playful behavior, which is a positive indication,” the department noted.

The fun-loving furballs got free after a caretaker “failed to secure doors” at the facility.

Alpha Genesis staff have been keeping an eye on the escapees, trying to entice them back in with food. But, instead of taking the bait, the primates have been playing on the perimeter fence while still keeping in touch with the monkeys inside by cooing to them.

“They’re just being goofy monkeys jumping back and forth playing with each other,” Alpha Genesis CEO Greg Westergaard told CBS News Thursday. “It’s kind of like a playground situation here.”

Yemassee police note that the monkeys are very young and small—only about 6 or 7 pounds each. They have not been used for any testing yet, don’t carry any disease, and pose no health risk to the public. Still, area residents have been advised to keep their doors and windows locked in case the wee primates try to pay a visit.

This isn’t the first time—or even the second time—Alpha Genesis has had trouble keeping its monkeys under control. In 2018, the US Department of Agriculture fined the company $12,600 for violations between 2014 and 2016 that included four monkey breakouts. In those incidents, a total of 30 monkeys escaped. One was never found.

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Space policy is about to get pretty wild, y’all

Features, Science, Space / 9u50fv / November 8, 2024

Saddle up, space cowboys. It may get bumpy for a while.

President Donald Trump steps on the stage at Kennedy Space Center after the successful launch of the Demo-2 crew mission in May 2020. Credit: NASA/Bill Ingalls

The global space community awoke to a new reality on Wednesday morning.

The founder of this century’s most innovative space company, Elon Musk, successfully used his fortune, time, and energy to help elect Donald Trump to president of the United States. Already, Musk was the dominant Western player in space. SpaceX launches national security satellites and NASA astronauts and operates a megaconstellation. He controls the machines that provide essential space services to NASA and the US military. And now, thanks to his gamble on backing Trump, Musk has strong-armed himself into Trump’s inner circle.

Although he may not have a cabinet-appointed position, Musk will have a broad portfolio in the new administration for as long as his relations with Trump remain positive. This gives Musk extraordinary power over a number of areas, including spaceflight. Already this week, he has been soliciting ideas and input from colleagues. The New York Times reported that Musk has advised Trump to hire key employees from SpaceX into his administration, including at the Department of Defense. This reflects the huge conflict of interest that Musk will face when it comes to space policy. His actions could significantly benefit SpaceX, of which he is the majority owner and has the final say in major decisions.

It will be a hugely weird dynamic. Musk is unquestionably in a position for self-dealing. Normally, such conflicts of interest would be frowned on within a government, but Trump has already shown a brazen disregard for norms, and there’s no reason to believe that will change during his second go at the presidency. One way around this could be to give Musk a “special adviser” tag, which means he would not have to comply with federal conflict-of-interest laws.

So it’s entirely possible that the sitting chief executive of SpaceX could be the nation’s most important adviser on space policy, conflicts be damned. Musk possesses flaws as a leader, but it is difficult to argue against results. His intuitions for the industry, such as pushing hard for reusable launch and broadband Internet from space, have largely been correct. In a vacuum, it is not necessarily bad to have someone like Musk providing a vision for US spaceflight in the 21st century. But while space may be a vacuum, there is plenty of oxygen in Washington, DC.

Being a space journalist got a lot more interesting this week—and a lot more difficult. As I waded through this reality on Wednesday, I began to reach out to sources about what is likely to happen. It’s way too early to have much certainty, but we can begin to draw some broad outlines for what may happen to space policy during a second Trump presidency. Buckle up—it could be a wild ride.

Bringing efficiency to NASA?

Let’s start with NASA and firmly establish what we mean. The US space agency does some pretty great things, but it’s also a bloated bureaucracy. That’s by design. Members of Congress write budgets and inevitably seek to steer more federal dollars to NASA activities in the areas they represent. Two decades ago, an engineer named Mike Griffin—someone Musk sought to hire as SpaceX’s first chief engineer in 2002—became NASA administrator under President George W. Bush.

Griffin recognized NASA’s bloat. For starters, it had too many field centers. NASA simply doesn’t need 10 major outposts across the country, as they end up fighting one another for projects and funding. However, Griffin knew he would face a titanic political struggle to close field centers, on par with federal efforts to close duplicative military bases during the “Base Realignment and Closure” process after the Cold War. So Griffin instead sought to make the best of the situation with his “Ten Healthy Centers” initiative. Work together, he told his teams across the country.

Essentially, then, for the last two decades, NASA programs have sought to leverage expertise across the agency. Consider the development of the Orion spacecraft, which began nearly 20 years ago. The following comment comes from Julie Kramer-White from an oral history interview conducted in 2016. Kramer is a long-time NASA engineer who was chief engineer of Orion at the time.

“I’ll tell you the truth, ten healthy centers is a pain in the butt,” she said. “The engineering team is a big engineering team, and they are spread across 9 of the 10 Centers… Our guys don’t think anything about a phone call that’s got people from six different centers. You’re trying to balance the time zone differences, and of course that’s got its own challenge with Europe as well but even within the United States with the different centers managing the time zone issue. I would say as a net technically, it’s a good thing. From a management perspective, boy, it’s a hassle.”

Space does not get done fast or efficiently by committee. But that’s how NASA operates—committees within committees, reviewed by committees.

Musk has repeatedly said he wants to bring efficiency to the US government and vowed to identify $2 trillion in savings. Well, NASA would certainly be more efficient with fewer centers—each of which has its own management layers, human resources setups, and other extensive overhead. But will the Trump administration really have the stomach to close centers? Certainly the congressional leadership from a state like Ohio would fight tooth and nail for Glenn Research Center. This offers an example of how bringing sweeping change to the US government in general, and NASA in particular, will run into the power of the purse held by Congress.

One tool NASA has used in recent years to increase efficiency is buying commercial services rather than leading the development of systems, such as the Orion spacecraft. This most prominent example is cargo and crew transportation to the International Space Station, but NASA has extended this approach to all manner of areas, from space communications to lunar landers to privately operated space stations. Congress has not always been happy with this transition because it has lessened its influence over steering funding directly to centers. NASA has nonetheless continued to push for this change because it has lowered agency costs, allowing it to do more.

Yet here again we run into conflicts of interest with Musk. The primary reason that NASA’s transition toward buying services has been a success is due to SpaceX. Private companies not named SpaceX have struggled to compete as NASA awards more fixed-price contracts for space services. Given Congress’ love for directing space funds to local centers, it’s unlikely to let Musk overhaul the agency in ways that send huge amounts of new business to SpaceX.

Where art thou, Artemis?

The biggest question is what to do with the Artemis program to return humans to the Moon. Ars wrote extensively about some of the challenges with this program a little more than a month ago, and Michael Bloomberg, founder of Bloomberg News, wrote a scathing assessment of Artemis recently under the headline “NASA’s $100 billion Moon mission is going nowhere.”

It is unlikely that outright cancellation of Artemis is on the table—after all, the first Trump administration created Artemis six years ago. However, Musk is clearly focused on sending humans to Mars, and the Moon-first approach of Artemis was championed by former Vice President Mike Pence, who is long gone. Trump loves grand gestures, and Musk has told Trump it will be possible to send humans to Mars before the end of his term. (That would be 2028, and it’s almost impossible to see this happening for a lot of reasons.) The Artemis architecture was developed around a “Moon-then-Mars” philosophy—as in, NASA will send humans to the Moon now, with Mars missions pushed into a nebulous future. Whatever Artemis becomes, it is likely to at least put Mars on equal footing to the Moon.

Notably, Musk despises NASA’s Space Launch System rocket, a central element of Artemis. He sees the rocket as the epitome of government bloat. And it’s not hard to understand why. The Space Launch System is completely expendable and costs about 10 to 100 times as much to launch as his own massive Starship rocket.

The key function the SLS rocket and the Orion spacecraft currently provide in Artemis is transporting astronauts from Earth to lunar orbit and back. There are ways to address this. Trump could refocus Artemis on using Starship to get humans to Mars. Alternatively, he could direct NASA to kludge together some combination of Orion, Dragon, and Falcon rockets to get astronauts to the Moon. He might also direct NASA to use the SLS for now but cancel further upgrades to it and a lunar space station called Gateway.

“The real question is how far is a NASA landing team and beachhead team are willing to go in destabilizing the program of record,” one policy source told Ars. “I can’t see Trump and Vance being less willing to shake up NASA than they are other public policy zones.”

What does seem clear is that, for the first time in 15 years, canceling the Space Launch System rocket or dramatically reducing its influence is on the table. This will be an acid test for Musk and Trump’s rhetoric on government efficiency, since the base of support for Artemis is in the deep-red South: states like Alabama, Mississippi, Louisiana, and Florida.

Will they really cut jobs there in the name of efficiency?

Regulatory reform

Reducing government regulations is one area in which the pathway for Musk and Trump is clear. The first Trump administration pushed to reduce regulations on US businesses almost from day one. In spaceflight, this produced Space Policy Directive-2 in 2018. Some progress was made, but it was far from total.

For spaceflight, Musk’s goal is to get faster approval for Starship test flights and licensing for the (literally) hundreds of launches SpaceX is already conducting annually. This will be broadly supported by the second Trump administration. During Trump’s first term, some of the initiatives in Space Policy Directive-2 were slowed or blocked by the Federal Aviation Administration and NASA, but the White House push will be even harder this time.

A looser regulatory environment should theoretically lead to more and more rapid progress in commercial space capabilities.

It’s worth noting here that if you spend any time talking to space startup executives, they all have horror stories about interacting with the FAA or other agencies. Pretty much everyone agrees that regulators could be more efficient but also that they need more resources to process rules in a timely manner. The FAA and Federal Communications Commission have important jobs when it comes to keeping people on the ground safe and keeping orbits sustainable in terms of traffic and space junk.

The second Trump administration will have some important allies on this issue in Congress. Ted Cruz, the US Senator from Texas, will likely chair the Senate Committee on Commerce, Science, and Transportation, which oversees legislation for space activities. He is one of the senators who has shown the most interest in commercial space, and he will support pro-business legislation—that is, laws that allow companies freer rein and regulatory agencies fewer teeth. How far this gets will depend on whether Republicans keep the House or Democrats take control.

Other areas of change

Over the course of the last seven decades, space has largely been a non-partisan topic.

But Musk’s deepening involvement in US space policy could pose a serious problem to this, as he’s now viewed extremely negatively by many Democrats. It seems probable that many people in Congress will oppose any significant shift of NASA’s focus from the Moon to Mars, particularly because it aligns with Musk’s long-stated goal of making humans a multiplanetary species.

There are likely to be battles in space science, as well. Traditionally, Republican presidents have cut funding for Earth science missions, and Democrats have increased funding to better study and understand climate change. Generally, given the administration’s likely focus on human spaceflight, space science will probably take a back seat and may lose funding.

Another looming issue is Mars Sample Return, which NASA is reconsidering due to budget and schedule issues. Presently, the agency intends to announce a new plan for retrieving rock and soil samples from Mars and returning them to Earth in December.

But if Musk and Trump are bent on sending humans to Mars as soon as possible, there is little sense in the space agency spending billions of dollars on a robotic sample return mission. Astronauts can just bring them back inside Starship.

Finally, at present, NASA has rich partnerships with space agencies around the world. In fact, it was the first Trump administration that created the Artemis Accords a little more than four years ago to develop an international coalition to return to the Moon. Since then, the United States and China have both been signing up partners in their competition to establish a presence at the South Pole of the Moon.

One huge uncertainty is how some of NASA’s long-established partners, especially in Europe, where there is bound to be tension around Ukraine and other issues with the Trump administration, will react at the US space agency’s exploration plans. Europeans are already wary of SpaceX’s prowess in global spaceflight and likely will not want to be on board with any space activities that further Musk’s ambitions.

These are just some of the high-level questions facing NASA and US spaceflight. There are many others. For example, how will Trump’s proposed tariffs on key components impact the national security and civil space supply chain? And there’s the Department of Defense, where the military already has multibillion dollar contracts with SpaceX, and there are bound to be similar conflicts and ethical concerns.

No one can hear you scream in space, but there will be plenty of screaming about space in the coming months.

Eric Berger is the senior space editor at Ars Technica, covering everything from astronomy to private space to NASA policy, and author of two books: Liftoff, about the rise of SpaceX; and Reentry, on the development of the Falcon 9 rocket and Dragon. A certified meteorologist, Eric lives in Houston.

Space policy is about to get pretty wild, y’all Read More »

DNA shows Pompeii’s dead aren’t who we thought they were

ancient DNA, Archaeology, forensic archaeology, Pompeii, Science / Beth Washington / November 8, 2024

People have long been fascinated by the haunting plaster casts of the bodies of people who died in Pompeii when Mount Vesuvius erupted in 79 CE. Archaeologists have presented certain popular narratives about who these people might have been and how they might have been related. But ancient DNA analysis has revealed that those preferred narratives were not entirely accurate and may reflect certain cultural biases, according to a new paper published in the journal Current Biology. The results also corroborate prior research suggesting that the people of ancient Pompeii were the descendants of immigrants from the Eastern Mediterranean.

As previously reported, the eruption of Mount Vesuvius released thermal energy roughly equivalent to 100,000 times the atomic bombs dropped on Hiroshima and Nagasaki at the end of World War II, spewing molten rock, pumice, and hot ash over the cities of Pompeii and Herculaneum in particular. The vast majority of people in Pompeii and Herculaneum—the cities hardest hit—perished from asphyxiation, choking on the thick clouds of noxious gas and ash. But at least some of the Vesuvian victims probably died instantaneously from the intense heat of fast-moving lava flows, with temperatures high enough to boil brains and explode skulls.

In the first phase, immediately after the eruption, a long column of ash and pumice blanketed the surrounding towns, most notably Pompeii and Herculaneum. By late night or early morning, pyroclastic flows (fast-moving hot ash, lava fragments, and gases) swept through and obliterated what remained, leaving the bodies of the victims frozen in seeming suspended action.

In the 19th century, an archaeologist named Giuseppe Fiorelli figured out how to make casts of those frozen bodies by pouring liquid plaster into the voids where the soft tissue had been. Some 1,000 bodies have been discovered in the ruins, and 104 plaster casts have been preserved. Restoration efforts of 86 of those casts began about 10 years ago, during which researchers took CT scans and X-rays to see if there were complete skeletons inside. Those images revealed that there had been a great deal of manipulation of the casts, depending on the aesthetics of the era in which they were made, including altering some features of the bodies’ shapes or adding metal rods to stabilize the cast, as well as frequently removing bones before casting.

DNA shows Pompeii’s dead aren’t who we thought they were Read More »

After decades, FDA finally moves to pull ineffective decongestant off shelves

decongestant, fda, health, phenylephrine, Science, sudafed / Kelly Newman / November 7, 2024

In a long-sought move, the Food and Drug Administration on Thursday formally began the process of abandoning oral doses of a common over-the-counter decongestant, which the agency concluded last year is not effective at relieving stuffy noses.

Specifically, the FDA issued a proposed order to remove oral phenylephrine from the list of drugs that drugmakers can include in over-the-counter products—also known as the OTC monograph. Once removed, drug makers will no longer be able to include phenylephrine in products for the temporary relief nasal congestion.

“It is the FDA’s role to ensure that drugs are safe and effective,” Patrizia Cavazzoni, director of the FDA’s Center for Drug Evaluation and Research, said in a statement. “Based on our review of available data and consistent with the advice of the advisory committee, we are taking this next step in the process to propose removing oral phenylephrine because it is not effective as a nasal decongestant.”

For now, the order is just a proposal. The FDA will open up a public comment period, and if no comments can sway the FDA’s previous conclusion that the drug is useless, the agency will make the order final. Drugmakers will get a grace period to reformulate their products.

Reviewed reviews

The slow-moving abandonment of phenylephrine is years in the making. The decongestant was originally approved by the FDA back in 1976, but it came to prominence after 2006. That was the year when the “Combat Methamphetamine Epidemic Act of 2005” came into effect, and pseudoephedrine—the main component of Sudafed—moved behind the pharmacy counter to keep it from being used to make methamphetamine. With pseudoephedrine out of easy reach at drugstores, phenylephrine became the leading over-the-counter decongestant. And researchers had questions.

In 2007, an FDA panel reevaluated the drug, which allegedly works by shrinking blood vessels in the nasal passage, opening up the airway. While the panel upheld the drug’s approval, it concluded that more studies were needed for a full assessment. After that, three large, carefully designed studies were conducted—two by Merck for the treatment of seasonal allergies and one by Johnson & Johnson for the treatment of the common cold. All three found no significant difference between phenylephrine and a placebo.

After decades, FDA finally moves to pull ineffective decongestant off shelves Read More »

What makes baseball’s “magic mud” so special?

adhesion, baseball, geomaterials, materials science, Non-newtonian fluids, Physics, rheology, Science, soft matter / Beth Washington / November 7, 2024

“Magic mud” composition and microstructure: (top right) a clean baseball surface; (bottom right) a mudded baseball. Credit: S. Pradeep et al., 2024

Pradeep et al. found that magic mud’s particles are primarily silt and clay, with a bit of sand and organic material. The stickiness comes from the clay, silt, and organic matter, while the sand makes it gritty. So the mud “has the properties of skin cream,” they wrote. “This allows it to be held in the hand like a solid but also spread easily to penetrate pores and make a very thin coating on the baseball.”

When the mud dries on the baseball, however, the residue left behind is not like skin cream. That’s due to the angular sand particles bonded to the baseball by the clay, which can increase surface friction by as much as a factor of two. Meanwhile, the finer particles double the adhesion. “The relative proportions of cohesive particulates, frictional sand, and water conspire to make a material that flows like skin cream but grips like sandpaper,” they wrote.

Despite its relatively mundane components, the magic mud nonetheless shows remarkable mechanical behaviors that the authors think would make it useful in other practical applications. For instance, it might replace synthetic materials as an effective lubricant, provided the gritty sand particles are removed. Or it could be used as a friction agent to improve traction on slippery surfaces, provided one could define the optimal fraction of sand content that wouldn’t diminish its spreadability. Or it might be used as a binding agent in locally sourced geomaterials for construction.

“As for the future of Rubbing Mud in Major League Baseball, unraveling the mystery of its behavior does not and should not necessarily lead to a synthetic replacement,” the authors concluded. “We rather believe the opposite; Rubbing Mud is a nature-based material that is replenished by the tides, and only small quantities are needed for great effect. In a world that is turning toward green solutions, this seemingly antiquated baseball tradition provides a glimpse of a future of Earth-inspired materials science.”

DOI: PNAS, 2024. 10.1073/pnas.241351412 (About DOIs).

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Nearly three years since launch, Webb is a hit among astronomers

astronomy, James Webb Space Telescope, NASA, Science, Space, space telescope / 9u50fv / November 6, 2024

From its halo-like orbit nearly a million miles from Earth, the James Webb Space Telescope is seeing farther than human eyes have ever seen.

In May, astronomers announced that Webb detected the most distant galaxy found so far, a fuzzy blob of red light that we see as it existed just 290 million years after the Big Bang. Light from this galaxy, several hundreds of millions of times the mass of the Sun, traveled more than 13 billion years until photons fell onto Webb’s gold-coated mirror.

A few months later, in July, scientists released an image Webb captured of a planet circling a star slightly cooler than the Sun nearly 12 light-years from Earth. The alien world is several times the mass of Jupiter and the closest exoplanet to ever be directly imaged. One of Webb’s science instruments has a coronagraph to blot out bright starlight, allowing the telescope to resolve the faint signature of a nearby planet and use spectroscopy to measure its chemical composition.

These are just a taste of the discoveries made by the $10 billion Webb telescope since it began science observations in 2022. Judging by astronomers’ interest in using Webb, there are many more to come.

Breaking records

The Space Telescope Science Institute, which operates Webb on behalf of NASA and its international partners, said last week that it received 2,377 unique proposals from science teams seeking observing time on the observatory. The institute released a call for proposals earlier this year for the so-called “Cycle 4” series of observations with Webb.

This volume of proposals represents around 78,000 hours of observing time with Webb, nine times more than the telescope’s available capacity for scientific observations in this cycle. The previous observing cycle had a similar “oversubscription rate” but had less overall observing time available to the science community.

Nearly three years since launch, Webb is a hit among astronomers Read More »

For fame or a death wish? Kids’ TikTok challenge injuries stump psychiatrists

health, Mental Health, psychiatry, Science, suicide, tiktok, tiktok challenge / Beth Washington / November 6, 2024

Case dilemma

The researchers give the example of a 10-year-old patient who was found unconscious in her bedroom. The psychiatry team was called in to consult for a suicide attempt by hanging. But when the girl was evaluated, she was tearful, denied past or recent suicide attempts, and said she was only participating in the blackout challenge. Still, she reported being in depressed moods, having feelings of hopelessness, having thoughts of suicide since age 9, being bullied, and having no friends. Family members reported unstable housing, busy or absent parental figures, and a family history of a suicide attempts.

If the girl’s injuries were unintentional, stemming from the poor choice to participate in the life-threatening TikTok challenge, clinicians would discharge the patient home with a recommendation for outpatient mental health care to address underlying psychiatric conditions and stressors. But if the injuries were self-inflicted with an intent to die, the clinicians would recommend inpatient psychiatric treatment for safety, which would allow for further risk assessment, monitoring, and treatment for the suspected suicide attempt.

It’s critical to make the right call here. Children and teens who attempt suicide are at risk of more attempts, both immediately and in the future. But to make matters even more complex, injuries from social media challenges have the potential to spur depression and post-traumatic stress disorder. Those, in turn, could increase the risk of suicide attempts.

To keep kids and teens safe, the Ataga and Arnold call for more awareness about the dangers of TikTok challenges, as well as empathetic psychiatric assessments using kid-appropriate measurements. They also call for more research. While there are a handful of case studies on TikTok challenge injuries and deaths among kids and teens, there’s a lack of large-scale data. More research is needed to “demonstrate the role of such challenges as precipitating factors in unintentional and intentional injuries, suicidal behaviors, and deaths among children in the US,” the psychiatrists write.

If you or someone you know is in crisis, call or text 988 for the Suicide and Crisis Lifeline or contact the Crisis Text Line by texting TALK to 741741.

For fame or a death wish? Kids’ TikTok challenge injuries stump psychiatrists Read More »

The next Starship launch may occur in less than two weeks

raptor, Science, Space, starship, test flight / Shannon Garcia / November 6, 2024

The company will also use Starship’s next flight to assess new tiles and other elements of the vehicle’s heat shield.

“Several thermal protection experiments and operational changes will test the limits of Starship’s capabilities and generate flight data to inform plans for ship catch and reuse,” the company’s statement said. “The flight test will assess new secondary thermal protection materials and will have entire sections of heat shield tiles removed on either side of the ship in locations being studied for catch-enabling hardware on future vehicles. The ship also will intentionally fly at a higher angle of attack in the final phase of descent, purposefully stressing the limits of flap control to gain data on future landing profiles.”

Final flight of the first Starship

The five previous flights of Starship, dating back to April 2023, have all launched near dawn from South Texas. For the upcoming mission, the company will look for a late-afternoon launch window, which will allow the vehicle to reenter during daylight into the Indian Ocean.

SpaceX’s update also confirms that this will be the last flight of the initial version of the Starship vehicle, with the next generation including redesigned forward flaps, larger propellant tanks, and newer tiles and secondary thermal protection layers.

Reaching a near-monthly cadence of Starship flights during only the second year of the vehicle’s operation is impressive, but it’s also essential if SpaceX wants to unlock the full potential of a rocket that needs multiple refueling launches to support Starship missions to the Moon or Mars.

Wednesday’s announcement comes the day after the US presidential election in which Donald Trump was given a second term by American voters, and it is notable that he was assisted in this through an all-out effort by SpaceX founder Elon Musk.

Musk’s interventions in politics were highly controversial and alienated a significant segment of the US population and political class. Nevertheless Musk’s gambit paid off, as the election of Trump will now likely accelerate Starship’s development and increase its centrality to the nation’s space exploration endeavors.

However, the timing of this launch announcement is likely coincidental, as SpaceX did not need formal regulatory approval to move ahead with this sixth attempt—it was almost entirely dependent on the readiness of the company’s hardware, software, and ground systems.

The next Starship launch may occur in less than two weeks Read More »

“Havard”-trained spa owner injected clients with bogus Botox, prosecutors say

botox, counterfeit, fda, fraud, health, Science, skin fillers, spa / Shannon Garcia / November 5, 2024

Mounting evidence

Multiple clients and employees told investigators that Fadanelli also said she is a registered nurse, which is false. Though she is a registered aesthetician, aestheticians are not permitted to administer injections or prescription drugs.

Investigators set up an undercover operation where an agent went in for a consultation, and Fadanelli provided a quote for a $450 Botox treatment. Investigators also obtained videos and images of Fadanelli performing injections. And the evidence points to those injections being counterfeit, prosecutors allege. Sales records from the spa indicate that Fadanelli performed 1,631 “Botox” injections, 95 “Sculptra” injections, and 990 injections of unspecified “filler,” all totaling over $933,000. But sales records from the manufacturers of the brand name drugs failed to turn up any record of Fadanelli or anyone else from her spa ever purchasing legitimate versions of the drugs.

Despite the mounting evidence against her, Fadanelli reportedly stuck to her story, denying that she ever told anyone she was a nurse and denying ever administering any injections. “When agents asked Fadanelli if she would like to retract or modify that claim if she knew there was evidence showing that she was in fact administering such products, she reiterated that she does not administer injections.”

Ars has reached to Fadanelli’s spa for comment and will update this story if we get a response. According to the affidavit, clients who received the allegedly bogus injections complained of bumps, tingling, and poor appearances, but no infections or other adverse health outcomes.

In a press release announcing her arrest, Acting United States Attorney for Massachusetts Joshua Levy said: “For years, Ms. Fadanelli allegedly put unsuspecting patients at risk by representing herself to be a nurse and then administering thousands of illegal, counterfeit injections. … The type of deception alleged here is illegal, reckless, and potentially life-threatening.”

For a charge of illegal importation, Fadanelli faces up to 20 years in prison and a $250,000 fine. For each of two charges of knowingly selling or dispensing a counterfeit drug or counterfeit device, she faces up to 10 years in prison and a fine of $250,000.

“Havard”-trained spa owner injected clients with bogus Botox, prosecutors say Read More »

Endurance tells story of two expeditions, centuries apart

Disney Plus, Endurance shipwreck, exploration, National Geographic, Science, science documentaries, Sir Ernest Shackleton, streaming television / DJ Henderson / November 5, 2024

New NatGeo documentary was directed by the same duo who brought us the Oscar-winning Free Solo.

The intact stern of the good ship Endurance. Credit: Falklands Maritime Heritage Trust

The story of Arctic explorer Ernest Shackleton’s failed 1914 expedition to be the first to traverse the continent of Antarctica has long captured the popular imagination, as have the various efforts to locate the wreckage of his ship, the Endurance. The ship was finally found in 2022, nearly 107 years after it sank beneath the ice. The stories of Shackleton’s adventures and the 2022 expedition are told in parallel in Endurance, a new documentary from National Geographic now streaming on Disney+.

Endurance is directed by Oscar winners Jimmy Chin and Chai Vasarhelyi (Free Solo). According to Vasarhelyi, she and Chin had been obsessed with the Shackleton story for a long time. The discovery of the shipwreck in 2022 gave them the perfect opportunity to tell the story again for a new audience, making use of all the technological advances that have been made in recent years.

“I think the Shackleton story is at the heart of the DNA of our films,” Vasarhelyi told Ars. “It’s the greatest human survival story ever. It really speaks to having these audacious objectives and dreams. When everyone tells you that you can’t, you want to do it anyway. It requires you to then have the actual courage, grit, discipline, and strength of character to see it through. Shackleton is that story. He didn’t sensibly achieve any of his goals, but through his failure he found his strength: being able to inspire the confidence of his men.”

As previously reported, Endurance set sail from Plymouth on August 6, 1914, with Shackleton joining his crew in Buenos Aires, Argentina. By the time they reached the Weddell Sea in January 1915, accumulating pack ice and strong gales slowed progress to a crawl. Endurance became completely icebound on January 24, and by mid-February, Shackleton ordered the boilers to be shut off so that the ship would drift with the ice until the weather warmed sufficiently for the pack to break up. It would be a long wait. For 10 months, the crew endured the freezing conditions. In August, ice floes pressed into the ship with such force that the ship’s decks buckled.

The ship’s structure nonetheless remained intact, but by October 25, Shackleton realized Endurance was doomed. He and his men opted to camp out on the ice some two miles (3.2 km) away, taking as many supplies as they could with them. Compacted ice and snow continued to fill the ship until a pressure wave hit on November 13, crushing the bow and splitting the main mast—all of which was captured on camera by crew photographer Frank Hurley. Another pressure wave hit in the late afternoon on November 21, lifting the ship’s stern. The ice floes parted just long enough for Endurance to finally sink into the ocean before closing again to erase any trace of the wreckage.

When the sea ice finally disintegrated in April 1916, the crew launched lifeboats and managed to reach Elephant Island five days later. Shackleton and five of his men set off for South Georgia the next month to get help—a treacherous 720-mile journey by open boat. A storm blew them off course, and they ended up landing on the unoccupied southern shore. So Shackleton left three men behind while he and a companion navigated dangerous mountain terrain to reach the whaling station at Stromness on May 2. A relief ship collected the other three men and finally arrived back on Elephant Island in August. Miraculously, Shackleton’s crew was still alive.

Icebound

Ernest Shackleton aboard the Endurance. BF/Frank Hurley

Hurley’s photographs and footage—including Hurley’s 1919 feature documentary, South—were a crucial source for Vasarhelyi and Chin, as was the use of supplementary footage from 1920s and 1930s films depicting polar expeditions. The directors even convinced the British Film Institute to let them color-treat some of the original expedition footage.

“The BFI had lovingly restored the footage and been great custodians of it, but they also had been very strict about never color treating the footage,” said Vasarhelyi. “We made our argument and it shows what great partners they were that they agreed. It’s not colorized, it’s color treated, which is a slight difference. It just added drama and personality where suddenly you could kind of see the faces in a way that you couldn’t just by adding contrast. It was just trying to animate and identify and connect audiences with this story.”

The directors filmed original re-enactments for those parts of the Shackleton story that Hurley was not on hand to visually document firsthand, because he left his equipment behind when the crew was forced to abandon the Endurance. All he had after that was a small pocket camera. And Hurley wasn’t with Shackleton for the final rescue expedition. Most of the outdoor re-enactments were shot on location in Iceland, while some interior re-enactments were shot on a soundstage in Los Angeles.

This involved shooting under harsh freezing conditions on Icelandic glaciers in January and required building replica boats and sourcing period-specific costumes. Fortunately, “Burberry, who had made the original Shackleton gear, had the pattern still and they knew what type of leather it was,” said Vasarhelyi. “And so they made us 11 costume outfits that are the real costumes. We were able to source models of the real artifacts. The ice was freezing on the Burberry coats. The [re-enactors] had 9-millimeter wetsuits inside the Burberry outfits.”

Chin and Vasarhelyi also relied on the diaries of various crew members to capture the events in the crew’s voices. “The proper way into the Shackleton stories is through the diaries because you have primary accounts from many different points of view of the same events,” said Vasarhelyi. “But how to make it feel… vivid was the question.” The answer: using AI to reproduce the voices of Shackleton and others as preserved in historical recordings. They were able to sample those original voices and build an AI model from that, applying it to present-day voices (selected for their similarities to the original voices) reading the text.

Vasarhelyi acknowledges this was a controversial choice but defends the decision because it brought another dimension of immediacy to the final documentary. “Every part of me thinks that we have to educate ourselves; we need to regulate it,” she said. “I support our guilds in trying to protect our creative rights. But in this case, it was a good tool to use. For me, there was a real goosebump moment, watching Frank Hurley’s footage and you realize that you actually are watching real events that are 110 years old that were filmed by guys who survived two years in the ice without their boat. And then you add the tools of sound design and there is just something magical about it.“

The hunt for Endurance

The S.A. Agulhas II surrounded by sea ice as it makes its way toward the coordinates to find the Endurance. Falklands Maritime Heritage Trust/James Blake

People had been hunting for the wreckage of the Endurance ever since its sinking. Shackleton’s brilliant navigator, Frank Worsley, painstakingly calculated the coordinates for the position where Endurance sank using a sextant and chronometer. He recorded that position in his log book: 68°39’30” south; 52°26’30” west. But there was some question as to the accuracy of the marine chronometers he used to fix longitude, which would have affected the final coordinates.

Organized by the Falklands Maritime Heritage Trust, the $10 million Endurance22 expedition team set sail from Cape Town, South Africa, in early February on board the icebreaker S.A. Agulhas II. They arrived at the search area 10 days later. To account for any navigational errors by Worsley, the search area was quite broad. The team used battery-powered submersibles to comb the ocean floor for six-hour stretches, twice a day, augmented with sonar scans of the seabed to hunt for any protrusions. There was a limited window to find the wreck before the ice froze up and trapped the S.A. Agulhas II (the expedition vessel) in the ice, much like the Endurance.

There was a moment when the 2022 expedition members thought they had succeeded, but the object glimpsed in the data turned out to be a debris field from the vessel, not the vessel itself. Still, it was a promising sign, and the expedition persevered. After all, “How can you be associated with the Shackleton story and give up?” said Vasarhelyi.

One sticking point was determining the direction of drift after the Endurance sank. The team had the idea of combining the original 1914 observations with an AI weather model created by the European Union and essentially running it backward to narrow the search further. “That’s another ‘good’ AI moment,” said Vasarhelyi. “It was one of those moments where the past spoke to the present that the whole movie turns on. But there is an argument that they could have maybe looked at this data a little earlier.”

Finally, as the search was coming down to the wire, the Endurance22 team finally found the long-sought wreckage 3,008 meters down, roughly four miles (6.4 km) south of the ship’s last recorded position. The ship was in pristine condition partly because of the lack of wood-eating microbes in those waters. In fact, the Endurance22 expedition’s exploration director, Mensun Bound, told The New York Times at the time that the shipwreck was the finest example he’s ever seen; Endurance was “in a brilliant state of preservation.”

Once the wreck had been found, the team recorded as much as they could with high-resolution cameras and other instruments. Vasarhelyi, particularly, noted the technical challenge of deploying a remote digital 4K camera with lighting at 9,800 feet underwater, and the first deployment at that depth of photogrammetric and laser technology, resulting in a stunning millimeter-scale digital reconstruction of the entire shipwreck. “The payoff [was] seeing that incredible 3D imagery from 3,000 feet below the Weddell Sea,” she said.

What lies beneath

The Endurance as discovered underwater during the 2022 expedition. Falklands Maritime Heritage Trust

Chin and Vasarhelyi skillfully wove together these parallel storylines for their documentary: Shackleton and his men struggling to survive and Expedition22 racing against time to find the wreckage of the Endurance. “Because they actually found it, the 2022 expedition gave us an amazing payoff to this story,” said Vasarhelyi. “But the stakes of both narratives are very different. One is mortal stakes, and the other one is reputational. I think that the reasons why individuals find themselves in these circumstances are really interesting because normally they’re pretty personal, and people can identify with that.”

It was challenging to decide how much to include of both narrative threads; the directors certainly had enough material for five or more hours. They chose to focus on the broad strokes augmented by personal moments of humanity and occasional humor—not to mention heartbreak, such as the moment when Shackleton and his men are forced to kill their sled dogs for food. “We had a debate about whether to include the dogs, and I was like, ‘We have to,'” said Vasarhelyi. “It shows how desperate they were, and it also is a great character moment. That must have been awful, but it was the right thing to do, almost a merciful thing instead of letting them starve to death.”

Along with the tremendous courage and perseverance displayed by Shackleton and his men, Vasarhelyi said she was impressed with their grace under pressure. “I was astonished by the civility that Shackleton and his men depended on to preserve their humanity while they are in this dire circumstance, be it [putting on] burlesque shows or listening to the gramophone,” she said. “The story has an audacity and a strength of will that is inherently human and a view of leadership that felt so daring. This is really the holy grail of survival stories.”

Jennifer is a senior reporter at Ars Technica with a particular focus on where science meets culture, covering everything from physics and related interdisciplinary topics to her favorite films and TV series. Jennifer lives in Baltimore with her spouse, physicist Sean M. Carroll, and their two cats, Ariel and Caliban.

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NRO chief: “You can’t hide” from our new swarm of SpaceX-built spy satellites

Commercial space, military space, National Reconnaissance Office, Northrop Grumman, Science, Space, spacex, spy satellite, starlink, starshield / Beth Washington / November 5, 2024

“A satellite is always coming over an area within a given reasonable amount of time.”

This frame from a SpaceX video shows a stack of Starlink Internet satellites attached to the upper stage of a Falcon 9 rocket, moments after jettison of the launcher’s payload fairing. Credit: SpaceX

The director of the National Reconnaissance Office has a message for US adversaries around the world.

“You can’t hide, because we’re constantly looking,” said Chris Scolese, a longtime NASA engineer who took the helm of the US government’s spy satellite agency in 2019.

The NRO is taking advantage of SpaceX’s Starlink satellite assembly line to build a network of at least 100 satellites, and perhaps many more, to monitor adversaries around the world. So far, more than 80 of these SpaceX-made spacecraft, each a little less than a ton in mass, have launched on four Falcon 9 rockets. There are more to come.

A large number of these mass-produced satellites, or what the NRO calls a “proliferated architecture,” will provide regularly updated imagery of foreign military installations and other sites of interest to US intelligence agencies. Scolese said the new swarm of satellites will “get us reasonably high-resolution imagery of the Earth, at a high rate of speed.”

This is a significant change in approach for the NRO, which has historically operated a smaller number of more expensive satellites, some as big as a school bus.

“We expect to quadruple the number of satellites we have to have on-orbit in the next decade,” said Col. Eric Zarybnisky, director of the NRO’s office of space launch, during an October 29 presentation at the Wernher von Braun Space Exploration Symposium in Huntsville, Alabama.

The NRO is not the only national security agency eyeing a constellation of satellites in low-Earth orbit. The Pentagon’s Space Development Agency plans to kick off a rapid-fire launch cadence next year to begin placing hundreds of small satellites in orbit to detect and track missiles threatening US or allied forces. The Space Force is also interested in buying its own set of SpaceX satellites for broadband connectivity.

The Pentagon started moving in this direction about a decade ago, when leaders raised concerns that the legacy fleets of military and spy satellites were at risk of attack. Now, Elon Musk’s SpaceX and a handful of other companies, many of them startups, specialize in manufacturing and launching small satellites at relatively low cost.

“Why didn’t we do this earlier? Well, launch costs were high, right?” said Troy Meink, the NRO’s principal deputy director, in an October 17 discussion hosted by the Mitchell Institute for Aerospace Studies. “The cost of entry was pretty high, which has come way down. Then, digital electronics has allowed us to build capability in a much smaller package, and a combination of those two is really what’s enabled it.”

A constant vigil

NRO officials still expect to require some large satellites with sharp-eyed optics—think of a Hubble Space Telescope pointed at Earth—to resolve the finest details of things like missile installations, naval fleets, or insurgent encampments. The drawback of this approach is that, at best, a few big optical or radar imaging satellites only fly over places of interest several times per day.

With the proliferated architecture, the NRO will capture views of most places on Earth a lot more often. Two of the most important metrics with a remote-sensing satellite system are imaging resolution and revisit time, or how often a satellite is over a specific location on Earth.

“We need to have persistence or fast revisit,” Scolese said on October 3 in a discussion at the Center for Strategic and International Studies, a nonprofit Washington think tank. “You can proliferate your architecture, put more satellites up there, so that a satellite is always coming over an area within a given reasonable amount of time that’s needed by the users. That’s what we’re doing with the proliferated architecture.

“That’s enabled by a really rich commercial industry that’s building hundreds or thousands of satellites,” Scolese said. “That allowed us to take those satellites, adapt them to our use at low cost, and apply whatever sensor is needed to go off and acquire the information that’s needed at whatever revisit time is required.”

The NRO’s logo for its proliferated satellite constellation, with the slogan “Strength in Numbers.” Credit: National Reconnaissance Office

The NRO has identified other benefits, too. It’s a lot more difficult for a country like Russia or China to take out an entire constellation of satellites than to destroy or disable a single spy platform in orbit. Military officials have often referred to these expensive one-off satellites as “big juicy targets” for potential adversaries.

“It gives us a degree of resilience that we didn’t have before,” Scolese said.

The proliferated constellation also allows the NRO to be more nimble in responding to threats or new technologies. If a new type of sensor becomes available, or an adversary does something new that intelligence analysts want to look at, the NRO and its contractor can quickly swap out payloads on satellites going through the production line.

“That’s a huge change for an organization like the NRO,” Zarybnisky said. “It’s a catalyst. Another catalyst for innovation in the NRO is these smaller, lower price-point systems. Rapid turn time means you can introduce that next technology into the next generation and not wait for many years or even decades to introduce new technologies.”

Three-letter agencies

The NRO provides imaging, signals, and electronic intelligence data from its satellites to the National Security Agency, the National Geospatial-Intelligence Agency, and the Department of Defense. Scolese said the NRO wants to get actionable information into the hands of users across the federal government as quickly as possible, but the volume of data coming down from hundreds of satellites presents a challenge.

“Once you go to a proliferated architecture and you’re going from a few satellites to tens of satellites to now hundreds of satellites, you have to change a lot of things, and we’re in the process of doing that,” Scolese said.

With so many satellites, it “means that it’s no longer possible for an individual sitting at a control center to say, ‘I know what this satellite is doing,'” Scolese said. “So we have to have the machines to go off and help us there. We need artificial intelligence, machine learning, automated processes to help us do that.”

“We will deliver data in seconds, not minutes, and not hours,” Zarybnisky said.

The existence of this constellation was made public in March, when Reuters reported the NRO was working with SpaceX to develop and deploy a network of satellites in low-Earth orbit. SpaceX’s Starshield business unit is building the satellites under a $1.8 billion contract signed in 2021, according to Reuters. This is remarkably inexpensive by the standards of the NRO, which has spent more money just constructing a satellite processing facility at Cape Canaveral, Florida (thanks to Eric Berger’s reporting in Reentry for this juicy tidbit).

Chris Scolese appears before the Senate Armed Services Committee in 2019 during a confirmation hearing to become director of the National Reconnaissance Office. Credit: Tom Williams/CQ Roll Call

Reuters reported Northrop Grumman is supplying sensors to mount on at least some of the SpaceX-built satellites, but their design and capabilities remain classified. The NRO, which usually keeps its work secret, officially acknowledged the program in April, a month before the first batch of satellites launched from Vandenberg Space Force Base, California.

SpaceX revealed the existence of the Starshield division in 2022, the year after signing the NRO contract, as a vehicle for applying the company’s experience manufacturing Starlink Internet satellites to support US national security missions. SpaceX has built and launched more than 7,200 Starlink satellites since 2019, with more than 6,000 currently operational, 10 times larger than any other existing satellite constellation.

The current generation of Starlink satellites launch in batches of 20 to 23 spacecraft on SpaceX’s Falcon 9 rocket. They’re flat-packed one on top of the other inside the Falcon 9’s payload shroud, then released all at once in orbit. The NRO’s new satellites likely use the same basic design, launching in groups of roughly 21 satellites on each mission.

According to Scolese, the NRO owns these SpaceX-built satellites, rather than SpaceX owning them and supplying data to the government through a service contract arrangement. By the end of the year, the NRO’s director anticipates having at least 100 of these satellites in orbit, with additional launches expected through 2028.

“We are going from the demo phase to the operational phase, where we’re really going to be able to start testing all of this stuff out in a more operational way,” Scolese said.

The NRO is buttressing its network of government-owned satellites with data buys from commercial remote-sensing companies, such as Maxar, Planet, and BlackSky. One advantage of commercial imagery is the NRO can share it widely with allies and the public because it isn’t subject to top-secret classification restrictions.

Scolese said it’s important to maintain a diversity of sources and observation methods to overcome efforts from other nations to hide what they’re doing. This means using more satellites, as the NRO is doing with SpaceX and other commercial partners. It also means using electro-optical, radar, thermal infrared, and electronic detection sensors to fully characterize what intelligence analysts are seeing.

The NRO is also studying more exotic methods like quantum remote sensing, using the principles of quantum physics at the atomic level.

“There’s camouflage,” Scolese said. “There are lots of techniques that can be used, which means we have to go off and look at very different phenomenologies, and we’ve developed and are developing capabilities that will allow us to defeat those types of activities. Quantum sensing is one of them. You can’t really hide from fundamental physics.”

Stephen Clark is a space reporter at Ars Technica, covering private space companies and the world’s space agencies. Stephen writes about the nexus of technology, science, policy, and business on and off the planet.

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Drugmaker shut down after black schmutz found in injectable weight-loss drug

compounding pharmacies, eli lilly, fda, health, mounjaro, Novo Nordisk, Ozempic, safety, Science, wegovy, weight loss drugs, zepbound / Mike M. / November 4, 2024

It’s unclear how widely the pharmacy’s drugs were distributed. Fullerton Wellness could not be reached for comment.

Bigger battles

This is just the latest warning on weight-loss drugs from the FDA, which has repeatedly cautioned about quality and safety problems related to compounded versions of the drugs. The compounded drugs are intended to be essentially copycat versions of the blockbuster brand-name drugs. Compounding pharmacies can make copycat versions only as long as the drugs are in short supply, acting as a stopgap for patient access. But, with the popularity of the drugs and the high prices of the brand name versions, compounded formulations have become seen as affordable alternatives for many patients.

The situation has become a legal quagmire, with less-than-scrupulous compounding facilities drawing the ire of the FDA, and the big pharmaceutical companies fighting with their compounding competition. Eli Lilly, maker of Zepbound and Mounjaro (tirzepatide), and Novo Nordisk, maker of Wegovy and Ozempic (semaglutide), have both sued multiple compounding pharmacies over copycat versions of their lucrative drugs, which they claim are unsafe and fraudulent.

Meanwhile, in October, a trade organization for large-scale compounding pharmacies sued the FDA after the regulator removed tirzepatide from the drug shortage list, a move that blocks compounders from making copycat versions of the drug. But, the FDA quickly backpedaled in court, saying it would reconsider the removal and would allow compounders to keep producing off-brand versions in the meantime.

Also in October, Novo Nordisk asked the FDA to stop letting compounders make copycat versions of semaglutide, arguing that the drug is too complex for compounders to make and poses too many safety risks to patients. In response, the trade organization for compounders, the Outsourcing Facilities Association, submitted a letter to the FDA asking it to require Novo Nordisk to provide an economic impact statement to assess the cost and price increases that could occur if semaglutide were no longer available through compounding pharmacies.

Drugmaker shut down after black schmutz found in injectable weight-loss drug Read More »